Matches in SemOpenAlex for { <https://semopenalex.org/work/W4320179564> ?p ?o ?g. }
- W4320179564 endingPage "e13676" @default.
- W4320179564 startingPage "e13676" @default.
- W4320179564 abstract "Pigment epithelium-derived factor (PEDF) is a secreted glycoprotein involved in various biological processes. Its expression declines during ovarian carcinogenesis where it could decrease macrophages polarization, inhibit angiogenesis and induce apoptosis. Altogether, PEDF represents an ideal anti-cancer agent against ovarian cancer. We previously proposed the non-viral Sleeping Beauty transposon (SBT) system to stably integrate the PEDF transgene into ovarian cancer cells. Here, we report the development of liposomes and lipid nanoparticles for SBT-PEDF gene therapy. We determined that the SBT-PEDF nanolipid delivery system was the best system to increase the expression of PEDF in ovarian cancer spheroids. We also developed an ex vivo model of ovarian tumors which allowed us to show that nanolipoplexe in combination to paclitaxel exhibits synergistic and effective anti-tumor efficacy on ovarian tumors. These findings demonstrate that lipid nanoparticle for SBT-PEDF gene therapy may be a promising therapeutic approach for ovarian cancer." @default.
- W4320179564 created "2023-02-13" @default.
- W4320179564 creator A5017261148 @default.
- W4320179564 creator A5034156026 @default.
- W4320179564 creator A5034205871 @default.
- W4320179564 creator A5069108772 @default.
- W4320179564 creator A5071917263 @default.
- W4320179564 date "2023-02-01" @default.
- W4320179564 modified "2023-09-30" @default.
- W4320179564 title "NANO-SBT-PEDF delivery system: A promising approach against ovarian cancer?" @default.
- W4320179564 cites W1517954917 @default.
- W4320179564 cites W1812767048 @default.
- W4320179564 cites W1981182292 @default.
- W4320179564 cites W1993845012 @default.
- W4320179564 cites W2005041955 @default.
- W4320179564 cites W2026011922 @default.
- W4320179564 cites W2044012743 @default.
- W4320179564 cites W2047964603 @default.
- W4320179564 cites W2048767933 @default.
- W4320179564 cites W2057939348 @default.
- W4320179564 cites W2075997242 @default.
- W4320179564 cites W2086690729 @default.
- W4320179564 cites W2091991522 @default.
- W4320179564 cites W2092067882 @default.
- W4320179564 cites W2093262279 @default.
- W4320179564 cites W2100958924 @default.
- W4320179564 cites W2108845411 @default.
- W4320179564 cites W2122426257 @default.
- W4320179564 cites W2139159830 @default.
- W4320179564 cites W2142419911 @default.
- W4320179564 cites W2223986893 @default.
- W4320179564 cites W2260924656 @default.
- W4320179564 cites W2279252025 @default.
- W4320179564 cites W2419678096 @default.
- W4320179564 cites W2514184675 @default.
- W4320179564 cites W2520396976 @default.
- W4320179564 cites W2605708780 @default.
- W4320179564 cites W2895594057 @default.
- W4320179564 cites W2936858823 @default.
- W4320179564 cites W2983582756 @default.
- W4320179564 cites W2998375205 @default.
- W4320179564 cites W3024442472 @default.
- W4320179564 cites W3046751747 @default.
- W4320179564 cites W3055922424 @default.
- W4320179564 cites W3095652295 @default.
- W4320179564 cites W3194600479 @default.
- W4320179564 cites W4214862757 @default.
- W4320179564 cites W4281749171 @default.
- W4320179564 doi "https://doi.org/10.1016/j.heliyon.2023.e13676" @default.
- W4320179564 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36873150" @default.
- W4320179564 hasPublicationYear "2023" @default.
- W4320179564 type Work @default.
- W4320179564 citedByCount "0" @default.
- W4320179564 crossrefType "journal-article" @default.
- W4320179564 hasAuthorship W4320179564A5017261148 @default.
- W4320179564 hasAuthorship W4320179564A5034156026 @default.
- W4320179564 hasAuthorship W4320179564A5034205871 @default.
- W4320179564 hasAuthorship W4320179564A5069108772 @default.
- W4320179564 hasAuthorship W4320179564A5071917263 @default.
- W4320179564 hasBestOaLocation W43201795641 @default.
- W4320179564 hasConcept C104317684 @default.
- W4320179564 hasConcept C111599444 @default.
- W4320179564 hasConcept C121608353 @default.
- W4320179564 hasConcept C126322002 @default.
- W4320179564 hasConcept C133288520 @default.
- W4320179564 hasConcept C135983454 @default.
- W4320179564 hasConcept C141231307 @default.
- W4320179564 hasConcept C145059251 @default.
- W4320179564 hasConcept C190283241 @default.
- W4320179564 hasConcept C20518536 @default.
- W4320179564 hasConcept C2780394083 @default.
- W4320179564 hasConcept C2780427987 @default.
- W4320179564 hasConcept C3019054536 @default.
- W4320179564 hasConcept C4918238 @default.
- W4320179564 hasConcept C502942594 @default.
- W4320179564 hasConcept C52237779 @default.
- W4320179564 hasConcept C55493867 @default.
- W4320179564 hasConcept C71924100 @default.
- W4320179564 hasConcept C86803240 @default.
- W4320179564 hasConceptScore W4320179564C104317684 @default.
- W4320179564 hasConceptScore W4320179564C111599444 @default.
- W4320179564 hasConceptScore W4320179564C121608353 @default.
- W4320179564 hasConceptScore W4320179564C126322002 @default.
- W4320179564 hasConceptScore W4320179564C133288520 @default.
- W4320179564 hasConceptScore W4320179564C135983454 @default.
- W4320179564 hasConceptScore W4320179564C141231307 @default.
- W4320179564 hasConceptScore W4320179564C145059251 @default.
- W4320179564 hasConceptScore W4320179564C190283241 @default.
- W4320179564 hasConceptScore W4320179564C20518536 @default.
- W4320179564 hasConceptScore W4320179564C2780394083 @default.
- W4320179564 hasConceptScore W4320179564C2780427987 @default.
- W4320179564 hasConceptScore W4320179564C3019054536 @default.
- W4320179564 hasConceptScore W4320179564C4918238 @default.
- W4320179564 hasConceptScore W4320179564C502942594 @default.
- W4320179564 hasConceptScore W4320179564C52237779 @default.
- W4320179564 hasConceptScore W4320179564C55493867 @default.
- W4320179564 hasConceptScore W4320179564C71924100 @default.
- W4320179564 hasConceptScore W4320179564C86803240 @default.