Matches in SemOpenAlex for { <https://semopenalex.org/work/W4320205623> ?p ?o ?g. }
- W4320205623 endingPage "27" @default.
- W4320205623 startingPage "12" @default.
- W4320205623 abstract "Both chiral resolving agent and solvent from chiral resolution of the racemate were successfully recovered and recycled by slurry reactive crystallization of its diastereomeric salts. A solvent capable of solubilizing the resolving agent, but not the racemate and its diastereomeric salt products, was selected for chemical processing. The reaction was proceeded through the solid-solid conversion of the racemate into its diastereomeric salt pair, hence the term slurry reactive crystallization. An excessive amount of resolving agent was introduced to ensure reaction completeness, and the unreacted resolving agent was recovered in the filtrate along with the spent mother liquor which was made up by the selected solvent. The filtered solids of diastereomeric salt pair were resolved by recrystallization separately. The same mother liquor was reused as a suspending solvent medium for desalification of the diastereomeric salts by a strong achiral acid/base, in which the cracked resolving agent would be returned to the mother liquor as a solute. By this way, a closed-loop recycle of the resolving agent and suspending solvent medium could be achieved. This concept has been successfully proven by applying it to recover (S)-(-)-1-phenylethylamine as a resolving agent in the chiral resolution of (R,S)-(±)-ibuprofen, with the recovery of 68–70 wt% for up to three cycles. (R,S)-(±)-ibuprofen was resolved to 61–70 wt%R of enriched (R)-(-)-ibuprofen crystals, and up to 77–85 wt%S of enriched (S)-(+)-ibuprofen crystals for up to three cycles. By using this approach, chiral resolution of (R,S)-(±)-ibuprofen could be made to be sustainable with an E-factor of 39.8." @default.
- W4320205623 created "2023-02-13" @default.
- W4320205623 creator A5075267335 @default.
- W4320205623 creator A5088332400 @default.
- W4320205623 date "2023-04-01" @default.
- W4320205623 modified "2023-10-16" @default.
- W4320205623 title "Recycling of resolving agent and solvent by water-based reactions and phase diagrams: Chiral resolution study of racemic ibuprofen" @default.
- W4320205623 cites W1967401337 @default.
- W4320205623 cites W1968988473 @default.
- W4320205623 cites W1991683710 @default.
- W4320205623 cites W1992531788 @default.
- W4320205623 cites W2001377520 @default.
- W4320205623 cites W2007520445 @default.
- W4320205623 cites W2012662802 @default.
- W4320205623 cites W2024493796 @default.
- W4320205623 cites W2041658956 @default.
- W4320205623 cites W2043966259 @default.
- W4320205623 cites W2048678651 @default.
- W4320205623 cites W2049662435 @default.
- W4320205623 cites W2049724581 @default.
- W4320205623 cites W2051032318 @default.
- W4320205623 cites W2059907876 @default.
- W4320205623 cites W2067536394 @default.
- W4320205623 cites W2096022003 @default.
- W4320205623 cites W2125803253 @default.
- W4320205623 cites W2160004810 @default.
- W4320205623 cites W2162654093 @default.
- W4320205623 cites W2171228374 @default.
- W4320205623 cites W2183473183 @default.
- W4320205623 cites W2323943045 @default.
- W4320205623 cites W2325177685 @default.
- W4320205623 cites W2333831301 @default.
- W4320205623 cites W2512049727 @default.
- W4320205623 cites W2527330915 @default.
- W4320205623 cites W2539011977 @default.
- W4320205623 cites W2774552169 @default.
- W4320205623 cites W2790059152 @default.
- W4320205623 cites W2799616547 @default.
- W4320205623 cites W2899450793 @default.
- W4320205623 cites W2900138112 @default.
- W4320205623 cites W2937526146 @default.
- W4320205623 cites W2997409056 @default.
- W4320205623 cites W3005245683 @default.
- W4320205623 cites W3080162385 @default.
- W4320205623 cites W3096337065 @default.
- W4320205623 cites W3202584247 @default.
- W4320205623 cites W3203670214 @default.
- W4320205623 cites W4200538077 @default.
- W4320205623 cites W4200624964 @default.
- W4320205623 cites W4226153953 @default.
- W4320205623 cites W4317381237 @default.
- W4320205623 doi "https://doi.org/10.1016/j.cherd.2023.02.010" @default.
- W4320205623 hasPublicationYear "2023" @default.
- W4320205623 type Work @default.
- W4320205623 citedByCount "0" @default.
- W4320205623 crossrefType "journal-article" @default.
- W4320205623 hasAuthorship W4320205623A5075267335 @default.
- W4320205623 hasAuthorship W4320205623A5088332400 @default.
- W4320205623 hasConcept C138268822 @default.
- W4320205623 hasConcept C138716334 @default.
- W4320205623 hasConcept C151730666 @default.
- W4320205623 hasConcept C154945302 @default.
- W4320205623 hasConcept C156217769 @default.
- W4320205623 hasConcept C178790620 @default.
- W4320205623 hasConcept C185592680 @default.
- W4320205623 hasConcept C191295138 @default.
- W4320205623 hasConcept C195702682 @default.
- W4320205623 hasConcept C203036418 @default.
- W4320205623 hasConcept C2776371256 @default.
- W4320205623 hasConcept C2779944601 @default.
- W4320205623 hasConcept C2780471494 @default.
- W4320205623 hasConcept C41008148 @default.
- W4320205623 hasConcept C43617362 @default.
- W4320205623 hasConcept C486523 @default.
- W4320205623 hasConcept C71924100 @default.
- W4320205623 hasConcept C86803240 @default.
- W4320205623 hasConcept C98274493 @default.
- W4320205623 hasConceptScore W4320205623C138268822 @default.
- W4320205623 hasConceptScore W4320205623C138716334 @default.
- W4320205623 hasConceptScore W4320205623C151730666 @default.
- W4320205623 hasConceptScore W4320205623C154945302 @default.
- W4320205623 hasConceptScore W4320205623C156217769 @default.
- W4320205623 hasConceptScore W4320205623C178790620 @default.
- W4320205623 hasConceptScore W4320205623C185592680 @default.
- W4320205623 hasConceptScore W4320205623C191295138 @default.
- W4320205623 hasConceptScore W4320205623C195702682 @default.
- W4320205623 hasConceptScore W4320205623C203036418 @default.
- W4320205623 hasConceptScore W4320205623C2776371256 @default.
- W4320205623 hasConceptScore W4320205623C2779944601 @default.
- W4320205623 hasConceptScore W4320205623C2780471494 @default.
- W4320205623 hasConceptScore W4320205623C41008148 @default.
- W4320205623 hasConceptScore W4320205623C43617362 @default.
- W4320205623 hasConceptScore W4320205623C486523 @default.
- W4320205623 hasConceptScore W4320205623C71924100 @default.
- W4320205623 hasConceptScore W4320205623C86803240 @default.
- W4320205623 hasConceptScore W4320205623C98274493 @default.
- W4320205623 hasFunder F4320322795 @default.
- W4320205623 hasFunder F4320323229 @default.