Matches in SemOpenAlex for { <https://semopenalex.org/work/W4320481932> ?p ?o ?g. }
- W4320481932 abstract "HER2 belongs to the human epidermal growth factor receptor tyrosine kinase family. Its overexpression or hyperactivation is a leading cause for multiple types of cancers. HER2 functions mainly through dimerization with other family members, such as EGFR. However, the molecular details for heterodimer assembly have not been completely understood. Here, we report cryo-EM structures of the EGF- and epiregulin-bound EGFR/HER2 ectodomain complexes at resolutions of 3.3 Å and 4.5 Å, respectively. Together with the functional analyses, we demonstrate that only the dimerization arm of HER2, but not that of EGFR, is essential for their heterodimer formation and signal transduction. Moreover, we analyze the differential membrane dynamics and transient interactions of endogenous EGFR and HER2 molecules in genome-edited cells using single-molecule live-cell imaging. Furthermore, we show that the interaction with HER2 could allow EGFR to resist endocytosis. Together, this work deepens our understanding of the unique structural properties and dynamics of the EGFR/HER2 complex." @default.
- W4320481932 created "2023-02-14" @default.
- W4320481932 creator A5000875555 @default.
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- W4320481932 date "2023-02-13" @default.
- W4320481932 modified "2023-10-16" @default.
- W4320481932 title "Structure and dynamics of the EGFR/HER2 heterodimer" @default.
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- W4320481932 doi "https://doi.org/10.1038/s41421-023-00523-5" @default.
- W4320481932 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36781849" @default.
- W4320481932 hasPublicationYear "2023" @default.
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