FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4320484641> ?p ?o ?g. }

• W4320484641 endingPage "596" @default.
• W4320484641 startingPage "586" @default.
• W4320484641 abstract "Background: The comparative real-world outcomes of older patients with atrial fibrillation (AF) treated with anticoagulation compared with left atrial appendage occlusion (LAAO) may be different from those in clinical trials because of differences in anticoagulation strategies and patient demographics, including a greater proportion of women. We sought to compare real-world outcomes between older patients with AF treated with anticoagulation and those treated with LAAO by sex. Methods: Using Medicare claims data from 2015 to 2019, we identified LAAO-eligible beneficiaries and divided them into sex subgroups. Patients receiving LAAO were matched 1:1 to those receiving anticoagulation alone through propensity score matching. The risks of mortality, stroke or systemic embolism, and bleeding were compared between matched groups with adjustment for potential confounding characteristics in Cox proportional hazards models. Results: Among women, 4085 LAAO recipients were matched 1:1 to those receiving anticoagulation; among men, 5378 LAAO recipients were similarly matched. LAAO was associated with a significant reduction in the risk of mortality for women and men (hazard ratio [HR], 0.509 [95% CI, 0.447–0.580]; and HR, 0.541 [95% CI, 0.487–0.601], respectively; P <0.0001), with a similar finding for stroke or systemic embolism (HR, 0.655 [95% CI, 0.555–0.772]; and HR, 0.649 [95% CI, 0.552–0.762], respectively; P <0.0001). Bleeding risk was significantly greater in LAAO recipients early after implantation but lower after the 6-week periprocedural period for women and men (HR, 0.772 [95% CI, 0.676–0.882]; and HR, 0.881 [95% CI, 0.784–0.989], respectively; P <0.05). Conclusions: In a real-world population of older Medicare beneficiaries with AF, compared with anticoagulation, LAAO was associated with a reduction in the risk of death, stroke, and long-term bleeding among women and men. These findings should be incorporated into shared decision-making with patients considering strategies for reduction in AF-related stroke." @default.
• W4320484641 created "2023-02-14" @default.
• W4320484641 creator A5026475907 @default.
• W4320484641 creator A5038070724 @default.
• W4320484641 creator A5041009001 @default.
• W4320484641 creator A5052324988 @default.
• W4320484641 creator A5068655863 @default.
• W4320484641 creator A5075316902 @default.
• W4320484641 creator A5082268512 @default.
• W4320484641 creator A5084326780 @default.
• W4320484641 creator A5087100639 @default.
• W4320484641 date "2023-02-14" @default.
• W4320484641 modified "2023-10-06" @default.
• W4320484641 title "Comparative Effectiveness of Left Atrial Appendage Occlusion Versus Oral Anticoagulation by Sex" @default.
• W4320484641 cites W1833304681 @default.
• W4320484641 cites W1969493768 @default.
• W4320484641 cites W2107020336 @default.
• W4320484641 cites W2107050765 @default.
• W4320484641 cites W2112970567 @default.
• W4320484641 cites W2131850093 @default.
• W4320484641 cites W2178949224 @default.
• W4320484641 cites W2283863574 @default.
• W4320484641 cites W2766540689 @default.
• W4320484641 cites W2802157333 @default.
• W4320484641 cites W2885500738 @default.
• W4320484641 cites W2912139642 @default.
• W4320484641 cites W2930842499 @default.
• W4320484641 cites W2957544571 @default.
• W4320484641 cites W2990648202 @default.
• W4320484641 cites W3013229569 @default.
• W4320484641 cites W3035828091 @default.
• W4320484641 cites W3037621015 @default.
• W4320484641 cites W3092098557 @default.
• W4320484641 cites W3119560890 @default.
• W4320484641 cites W3120000023 @default.
• W4320484641 cites W3192053134 @default.
• W4320484641 cites W3212814686 @default.
• W4320484641 cites W4200456592 @default.
• W4320484641 cites W4225284539 @default.
• W4320484641 cites W4292234979 @default.
• W4320484641 cites W4297964979 @default.
• W4320484641 cites W50472604 @default.
• W4320484641 doi "https://doi.org/10.1161/circulationaha.122.062765" @default.
• W4320484641 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36780379" @default.
• W4320484641 hasPublicationYear "2023" @default.
• W4320484641 type Work @default.
• W4320484641 citedByCount "6" @default.
• W4320484641 countsByYear W43204846412023 @default.
• W4320484641 crossrefType "journal-article" @default.
• W4320484641 hasAuthorship W4320484641A5026475907 @default.
• W4320484641 hasAuthorship W4320484641A5038070724 @default.
• W4320484641 hasAuthorship W4320484641A5041009001 @default.
• W4320484641 hasAuthorship W4320484641A5052324988 @default.
• W4320484641 hasAuthorship W4320484641A5068655863 @default.
• W4320484641 hasAuthorship W4320484641A5075316902 @default.
• W4320484641 hasAuthorship W4320484641A5082268512 @default.
• W4320484641 hasAuthorship W4320484641A5084326780 @default.
• W4320484641 hasAuthorship W4320484641A5087100639 @default.
• W4320484641 hasConcept C126322002 @default.
• W4320484641 hasConcept C127413603 @default.
• W4320484641 hasConcept C141071460 @default.
• W4320484641 hasConcept C144024400 @default.
• W4320484641 hasConcept C149923435 @default.
• W4320484641 hasConcept C164705383 @default.
• W4320484641 hasConcept C17923572 @default.
• W4320484641 hasConcept C207103383 @default.
• W4320484641 hasConcept C2776301958 @default.
• W4320484641 hasConcept C2777185221 @default.
• W4320484641 hasConcept C2779161974 @default.
• W4320484641 hasConcept C2779668873 @default.
• W4320484641 hasConcept C2780084366 @default.
• W4320484641 hasConcept C2780434050 @default.
• W4320484641 hasConcept C2780645631 @default.
• W4320484641 hasConcept C44249647 @default.
• W4320484641 hasConcept C50382708 @default.
• W4320484641 hasConcept C71924100 @default.
• W4320484641 hasConcept C77350462 @default.
• W4320484641 hasConcept C78519656 @default.
• W4320484641 hasConceptScore W4320484641C126322002 @default.
• W4320484641 hasConceptScore W4320484641C127413603 @default.
• W4320484641 hasConceptScore W4320484641C141071460 @default.
• W4320484641 hasConceptScore W4320484641C144024400 @default.
• W4320484641 hasConceptScore W4320484641C149923435 @default.
• W4320484641 hasConceptScore W4320484641C164705383 @default.
• W4320484641 hasConceptScore W4320484641C17923572 @default.
• W4320484641 hasConceptScore W4320484641C207103383 @default.
• W4320484641 hasConceptScore W4320484641C2776301958 @default.
• W4320484641 hasConceptScore W4320484641C2777185221 @default.
• W4320484641 hasConceptScore W4320484641C2779161974 @default.
• W4320484641 hasConceptScore W4320484641C2779668873 @default.
• W4320484641 hasConceptScore W4320484641C2780084366 @default.
• W4320484641 hasConceptScore W4320484641C2780434050 @default.
• W4320484641 hasConceptScore W4320484641C2780645631 @default.
• W4320484641 hasConceptScore W4320484641C44249647 @default.
• W4320484641 hasConceptScore W4320484641C50382708 @default.
• W4320484641 hasConceptScore W4320484641C71924100 @default.
• W4320484641 hasConceptScore W4320484641C77350462 @default.
• W4320484641 hasConceptScore W4320484641C78519656 @default.

• next