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• W4320485220 abstract "We develop a mesoscopic approach to model the non-equilibrium behavior of membranes at the cellular scale. Relying on lattice Boltzmann methods, we develop a solution procedure to recover the Nernst-Planck equations and Gauss's law. A general closure rule is developed to describe mass transport across the membrane, which is able to account for protein-mediated diffusion based on a coarse-grained representation. We demonstrate that our model is able to recover the Goldman equation from first principles and show that hyper-polarization occurs when membrane charging dynamics are controlled by multiple relaxation timescales. The approach provides a promising way to characterize non-equilibrium behaviors that arise due to the role of membranes in mediating transport based on realistic three-dimensional cell geometries." @default.
• W4320485220 created "2023-02-14" @default.
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• W4320485220 date "2023-02-13" @default.
• W4320485220 modified "2023-09-24" @default.
• W4320485220 title "Capturing membrane structure and function in lattice Boltzmann models" @default.
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• W4320485220 doi "https://doi.org/10.1103/physreve.107.024408" @default.
• W4320485220 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36932594" @default.
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