Matches in SemOpenAlex for { <https://semopenalex.org/work/W4320486721> ?p ?o ?g. }
- W4320486721 abstract "Terpene cyclases catalyze one of the most powerful transformations with respect to efficiency and selectivity in natural product (bio)synthesis. In such polyene cyclizations, structurally highly complex carbon scaffolds are built by the controlled ring closure of linear polyenes. Thereby, multiple C,C bonds and stereocenters are simultaneously created with high precision. Structural pre-organization of the substrate carbon chain inside the active center of the enzyme is responsible for the product- and stereoselectivity of this cyclization. Here, we show that in-situ formed fluorinated-alcohol-amine supramolecular clusters serve as artificial cyclases by triggering enzyme-like reactivity and selectivity by controlling substrate conformation in solution. Because of the dynamic nature of these supramolecular assemblies, a broad range of terpenes can be produced diastereoselectively. Mechanistic studies reveal a finely balanced interplay of fluorinated solvent, catalyst, and substrate as key to establishing nature's concept of a shape-selective polyene cyclization in organic synthesis." @default.
- W4320486721 created "2023-02-14" @default.
- W4320486721 creator A5005449121 @default.
- W4320486721 creator A5006460670 @default.
- W4320486721 creator A5021605234 @default.
- W4320486721 creator A5024015184 @default.
- W4320486721 creator A5052374956 @default.
- W4320486721 creator A5070207581 @default.
- W4320486721 date "2023-02-13" @default.
- W4320486721 modified "2023-10-14" @default.
- W4320486721 title "Enzyme-like polyene cyclizations catalyzed by dynamic, self-assembled, supramolecular fluoro alcohol-amine clusters" @default.
- W4320486721 cites W147854008 @default.
- W4320486721 cites W1965583819 @default.
- W4320486721 cites W1965794748 @default.
- W4320486721 cites W1982214939 @default.
- W4320486721 cites W1987126722 @default.
- W4320486721 cites W1987770678 @default.
- W4320486721 cites W1993177346 @default.
- W4320486721 cites W1996869414 @default.
- W4320486721 cites W1997985416 @default.
- W4320486721 cites W2000910023 @default.
- W4320486721 cites W2001099861 @default.
- W4320486721 cites W2001928313 @default.
- W4320486721 cites W2009121443 @default.
- W4320486721 cites W2012187640 @default.
- W4320486721 cites W2030147784 @default.
- W4320486721 cites W2032939764 @default.
- W4320486721 cites W2043165163 @default.
- W4320486721 cites W2046050065 @default.
- W4320486721 cites W2047140022 @default.
- W4320486721 cites W2061364558 @default.
- W4320486721 cites W2063015507 @default.
- W4320486721 cites W2064333811 @default.
- W4320486721 cites W2071117176 @default.
- W4320486721 cites W2072427873 @default.
- W4320486721 cites W2078347593 @default.
- W4320486721 cites W2084303101 @default.
- W4320486721 cites W2086807245 @default.
- W4320486721 cites W2087013403 @default.
- W4320486721 cites W2093161659 @default.
- W4320486721 cites W2110267483 @default.
- W4320486721 cites W2112154906 @default.
- W4320486721 cites W2123773613 @default.
- W4320486721 cites W2124971322 @default.
- W4320486721 cites W2126428750 @default.
- W4320486721 cites W2138842037 @default.
- W4320486721 cites W2139137402 @default.
- W4320486721 cites W2227372968 @default.
- W4320486721 cites W2327067880 @default.
- W4320486721 cites W2334748593 @default.
- W4320486721 cites W2335752384 @default.
- W4320486721 cites W2346952428 @default.
- W4320486721 cites W2521204631 @default.
- W4320486721 cites W2557525213 @default.
- W4320486721 cites W2561997490 @default.
- W4320486721 cites W2584857446 @default.
- W4320486721 cites W2599148926 @default.
- W4320486721 cites W2622567059 @default.
- W4320486721 cites W2768088257 @default.
- W4320486721 cites W2773720018 @default.
- W4320486721 cites W2792911938 @default.
- W4320486721 cites W2794291180 @default.
- W4320486721 cites W2796172022 @default.
- W4320486721 cites W2804213337 @default.
- W4320486721 cites W2901628903 @default.
- W4320486721 cites W2941244538 @default.
- W4320486721 cites W2981168018 @default.
- W4320486721 cites W3017180782 @default.
- W4320486721 cites W3018181485 @default.
- W4320486721 cites W3024172218 @default.
- W4320486721 cites W3042706112 @default.
- W4320486721 cites W3082541940 @default.
- W4320486721 cites W3089515815 @default.
- W4320486721 cites W3097974838 @default.
- W4320486721 cites W4211259186 @default.
- W4320486721 cites W4220957635 @default.
- W4320486721 cites W4254039310 @default.
- W4320486721 cites W4285677181 @default.
- W4320486721 doi "https://doi.org/10.1038/s41467-023-36157-0" @default.
- W4320486721 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36781877" @default.
- W4320486721 hasPublicationYear "2023" @default.
- W4320486721 type Work @default.
- W4320486721 citedByCount "5" @default.
- W4320486721 countsByYear W43204867212023 @default.
- W4320486721 crossrefType "journal-article" @default.
- W4320486721 hasAuthorship W4320486721A5005449121 @default.
- W4320486721 hasAuthorship W4320486721A5006460670 @default.
- W4320486721 hasAuthorship W4320486721A5021605234 @default.
- W4320486721 hasAuthorship W4320486721A5024015184 @default.
- W4320486721 hasAuthorship W4320486721A5052374956 @default.
- W4320486721 hasAuthorship W4320486721A5070207581 @default.
- W4320486721 hasBestOaLocation W43204867211 @default.
- W4320486721 hasConcept C111368507 @default.
- W4320486721 hasConcept C118792377 @default.
- W4320486721 hasConcept C127313418 @default.
- W4320486721 hasConcept C131779359 @default.
- W4320486721 hasConcept C134195300 @default.
- W4320486721 hasConcept C142724271 @default.
- W4320486721 hasConcept C146686406 @default.
- W4320486721 hasConcept C161790260 @default.