FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4320487002> ?p ?o ?g. }

• W4320487002 endingPage "104575" @default.
• W4320487002 startingPage "104575" @default.
• W4320487002 abstract "Certain classes of multiple sclerosis (MS) disease modifying therapies (DMTs) have been associated with an increased risk of severe COVID-19, resulting in prescribers considering changes in their practice habits during the COVID-19 pandemic. This study assessed for differences in prescribing patterns of DMTs along with the reason(s) for modification of therapy over time.A retrospective review of medical records at Johns Hopkins Health System was performed. The timeframe of the study, April 2019 to December 2021, was divided into three subcategories: pre-pandemic (April 2019-March 2020), pre-vaccine availability (April 2020-March 2021), and post-vaccine availability (April 2021-December 2021). Patients were identified through dispense reports from the pharmacy dispensing system, and prescribing report from the health-system electronic health record (EHR). The health-system EHR was also utilized to conduct chart reviews for a subset of patients that had a modification in their therapy during the specified timeframes. The study included adult patients that were prescribed at least one DMT through the Johns Hopkins Pharmacy Services during the study timeframe and those who stayed on their DMT for at least 2 months without tolerability issues. Descriptive statistics were used to compare the prescribing practices during the timeframes with the percentage of prescribing for each type of treatment and to assess the percentage of patients that switched therapies in the different time periods.Based on prescribing report data, 670 patients were prescribed a DMT during the pre-pandemic period with infusion therapies being the most prescribed therapies during this timeframe (38%), followed by oral therapies at 35%. In comparison, a total of 620 patients were prescribed a DMT during pre-vaccine pandemic and the percentage of prescriptions of infusion therapies decreased to 28% (-10%) during this timeframe, whereas oral prescriptions increased to 42% (+7%). These trends continued during the post-vaccine timeframe where infusion therapies decreased to 26% (-12%) and oral therapies increased to 43% (+8%) in reference to the pre-pandemic period. Prescribing patterns of self-injectable therapies remained stable throughout the 3 timeframes. A dispensing report cohort of 500 patients were randomly selected for chart reviews to assess therapy modifications due to COVID-19. The percentage of therapy change due to COVID-19 increased to 45.2% during pre-vaccine period and remained at 38.4% during post-vaccine period when compared to the pre-pandemic reference period. The majority of changes due to COVID-19 were delays in infusion therapies (96% during pre-vaccine, and 94% during post-vaccine), not medication changes.Prescribing patterns and therapy modifications of DMTs for MS patients were impacted by COVID-19, with the greatest changes observed for the infusion therapies, including reduction in percentage of infusion prescriptions and delays in infusion therapies. Prescribing patterns of lower efficacy self-injectable therapies (interferon-beta and glatiramer acetate) remained stable. The outcomes of this study provide background for future outcomes-focused research studies in MS." @default.
• W4320487002 created "2023-02-14" @default.
• W4320487002 creator A5027323572 @default.
• W4320487002 creator A5029414789 @default.
• W4320487002 creator A5040896425 @default.
• W4320487002 creator A5043382133 @default.
• W4320487002 creator A5053542009 @default.
• W4320487002 creator A5056000599 @default.
• W4320487002 creator A5080257392 @default.
• W4320487002 date "2023-03-01" @default.
• W4320487002 modified "2023-10-17" @default.
• W4320487002 title "Impact of COVID-19 on prescribing patterns and treatment selection of disease modifying therapies in multiple sclerosis" @default.
• W4320487002 cites W1998761401 @default.
• W4320487002 cites W2579133420 @default.
• W4320487002 cites W3022375169 @default.
• W4320487002 cites W3035788771 @default.
• W4320487002 cites W3038240726 @default.
• W4320487002 cites W3137944655 @default.
• W4320487002 cites W3139311115 @default.
• W4320487002 cites W3162833512 @default.
• W4320487002 cites W3198197412 @default.
• W4320487002 cites W4211254511 @default.
• W4320487002 cites W4220661352 @default.
• W4320487002 cites W4220742828 @default.
• W4320487002 doi "https://doi.org/10.1016/j.msard.2023.104575" @default.
• W4320487002 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36857853" @default.
• W4320487002 hasPublicationYear "2023" @default.
• W4320487002 type Work @default.
• W4320487002 citedByCount "2" @default.
• W4320487002 countsByYear W43204870022023 @default.
• W4320487002 crossrefType "journal-article" @default.
• W4320487002 hasAuthorship W4320487002A5027323572 @default.
• W4320487002 hasAuthorship W4320487002A5029414789 @default.
• W4320487002 hasAuthorship W4320487002A5040896425 @default.
• W4320487002 hasAuthorship W4320487002A5043382133 @default.
• W4320487002 hasAuthorship W4320487002A5053542009 @default.
• W4320487002 hasAuthorship W4320487002A5056000599 @default.
• W4320487002 hasAuthorship W4320487002A5080257392 @default.
• W4320487002 hasBestOaLocation W43204870022 @default.
• W4320487002 hasConcept C104863432 @default.
• W4320487002 hasConcept C126322002 @default.
• W4320487002 hasConcept C177713679 @default.
• W4320487002 hasConcept C187212893 @default.
• W4320487002 hasConcept C194828623 @default.
• W4320487002 hasConcept C195910791 @default.
• W4320487002 hasConcept C197934379 @default.
• W4320487002 hasConcept C203014093 @default.
• W4320487002 hasConcept C2776036978 @default.
• W4320487002 hasConcept C2778375690 @default.
• W4320487002 hasConcept C2779134260 @default.
• W4320487002 hasConcept C2780640218 @default.
• W4320487002 hasConcept C2781004633 @default.
• W4320487002 hasConcept C3008058167 @default.
• W4320487002 hasConcept C512399662 @default.
• W4320487002 hasConcept C524204448 @default.
• W4320487002 hasConcept C71924100 @default.
• W4320487002 hasConcept C89623803 @default.
• W4320487002 hasConceptScore W4320487002C104863432 @default.
• W4320487002 hasConceptScore W4320487002C126322002 @default.
• W4320487002 hasConceptScore W4320487002C177713679 @default.
• W4320487002 hasConceptScore W4320487002C187212893 @default.
• W4320487002 hasConceptScore W4320487002C194828623 @default.
• W4320487002 hasConceptScore W4320487002C195910791 @default.
• W4320487002 hasConceptScore W4320487002C197934379 @default.
• W4320487002 hasConceptScore W4320487002C203014093 @default.
• W4320487002 hasConceptScore W4320487002C2776036978 @default.
• W4320487002 hasConceptScore W4320487002C2778375690 @default.
• W4320487002 hasConceptScore W4320487002C2779134260 @default.
• W4320487002 hasConceptScore W4320487002C2780640218 @default.
• W4320487002 hasConceptScore W4320487002C2781004633 @default.
• W4320487002 hasConceptScore W4320487002C3008058167 @default.
• W4320487002 hasConceptScore W4320487002C512399662 @default.
• W4320487002 hasConceptScore W4320487002C524204448 @default.
• W4320487002 hasConceptScore W4320487002C71924100 @default.
• W4320487002 hasConceptScore W4320487002C89623803 @default.
• W4320487002 hasLocation W43204870021 @default.
• W4320487002 hasLocation W43204870022 @default.
• W4320487002 hasLocation W43204870023 @default.
• W4320487002 hasOpenAccess W4320487002 @default.
• W4320487002 hasPrimaryLocation W43204870021 @default.
• W4320487002 hasRelatedWork W2053484098 @default.
• W4320487002 hasRelatedWork W2082301205 @default.
• W4320487002 hasRelatedWork W2337869809 @default.
• W4320487002 hasRelatedWork W2343984847 @default.
• W4320487002 hasRelatedWork W2551979274 @default.
• W4320487002 hasRelatedWork W2977883158 @default.
• W4320487002 hasRelatedWork W2978536138 @default.
• W4320487002 hasRelatedWork W4230124491 @default.
• W4320487002 hasRelatedWork W54639588 @default.
• W4320487002 hasRelatedWork W2264939213 @default.
• W4320487002 hasVolume "71" @default.
• W4320487002 isParatext "false" @default.
• W4320487002 isRetracted "false" @default.
• W4320487002 workType "article" @default.