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- W4320490663 abstract "Epithelial tissues provide front-line barriers shielding the organism from invading pathogens and harmful substances. In the airway epithelium, the combined action of multiciliated and secretory cells sustains the mucociliary escalator required for clearance of microbes and particles from the airways. Defects in components of mucociliary clearance or barrier integrity are associated with recurring infections and chronic inflammation. The timely and balanced differentiation of basal cells into mature epithelial cell subsets is therefore tightly controlled. While different growth factors regulating progenitor cell proliferation have been described, little is known about the role of metabolism in these regenerative processes. Here we show that basal cell differentiation correlates with a shift in cellular metabolism from glycolysis to fatty acid oxidation (FAO). We demonstrate both in vitro and in vivo that pharmacological and genetic impairment of FAO blocks the development of fully differentiated airway epithelial cells, compromising the repair of airway epithelia. Mechanistically, FAO links to the hexosamine biosynthesis pathway to support protein glycosylation in airway epithelial cells. Our findings unveil the metabolic network underpinning the differentiation of airway epithelia and identify novel targets for intervention to promote lung repair." @default.
- W4320490663 created "2023-02-14" @default.
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- W4320490663 date "2023-02-13" @default.
- W4320490663 modified "2023-10-18" @default.
- W4320490663 title "Repair of airway epithelia requires metabolic rewiring towards fatty acid oxidation" @default.
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- W4320490663 cites W1963449298 @default.
- W4320490663 cites W1974182237 @default.
- W4320490663 cites W1996235861 @default.
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- W4320490663 cites W2031846075 @default.
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- W4320490663 doi "https://doi.org/10.1038/s41467-023-36352-z" @default.
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