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- W4320491388 abstract "Parkinson’s disease (PD) is a prevalent type of neurodegenerative disease. There is mounting evidence that the gut microbiota is involved in the pathogenesis of PD. Sodium butyrate (NaB) can regulate gut microbiota and improve brain functioning in neurological disorders. Hence, we examined whether the neuroprotective function of NaB on PD was mediated by the modulation of gut microbial dysbiosis and revealed its possible mechanisms. Mice were administered 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) for 7 consecutive days to construct the PD model. NaB gavage was given 2 h after the daily MPTP injections for 21 days. NaB improved the motor functioning of PD mice, increased striatal neurotransmitter levels, and reduced the death of dopaminergic neurons. The 16S rRNA sequencing analysis revealed that NaB restored the gut microbial dysbiosis. NaB also attenuated the intestinal barrier’s disruption and reduced serum, colon, and striatal pro-inflammatory cytokines, along with inhibiting the overactivation of glial cells, suggesting an inhibitory effect on inflammation from NaB throughout the gut–brain axis of the PD mice. Mechanistic studies revealed that NaB treatment suppressed the TLR4/MyD88/NF-kB pathway in the colon and striatum. In summary, NaB had a neuroprotective impact on the PD mice, likely linked to its regulation of gut microbiota to inhibit gut–brain axis inflammation." @default.
- W4320491388 created "2023-02-14" @default.
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- W4320491388 date "2023-02-13" @default.
- W4320491388 modified "2023-10-05" @default.
- W4320491388 title "Neuroprotective Effects of Sodium Butyrate by Restoring Gut Microbiota and Inhibiting TLR4 Signaling in Mice with MPTP-Induced Parkinson’s Disease" @default.
- W4320491388 cites W1561072761 @default.
- W4320491388 cites W1569138725 @default.
- W4320491388 cites W1647551795 @default.
- W4320491388 cites W1903888485 @default.
- W4320491388 cites W1934236512 @default.
- W4320491388 cites W2000631088 @default.
- W4320491388 cites W2032519397 @default.
- W4320491388 cites W2042815338 @default.
- W4320491388 cites W2043292527 @default.
- W4320491388 cites W2085991415 @default.
- W4320491388 cites W2089298736 @default.
- W4320491388 cites W2111464898 @default.
- W4320491388 cites W2114037757 @default.
- W4320491388 cites W2117896755 @default.
- W4320491388 cites W2153192347 @default.
- W4320491388 cites W2182087156 @default.
- W4320491388 cites W2206572452 @default.
- W4320491388 cites W2403031333 @default.
- W4320491388 cites W2552041992 @default.
- W4320491388 cites W2558041282 @default.
- W4320491388 cites W2571212804 @default.
- W4320491388 cites W2587033728 @default.
- W4320491388 cites W2589764628 @default.
- W4320491388 cites W2599614419 @default.
- W4320491388 cites W2745136677 @default.
- W4320491388 cites W2747276149 @default.
- W4320491388 cites W2753113425 @default.
- W4320491388 cites W2772847295 @default.
- W4320491388 cites W2790863554 @default.
- W4320491388 cites W2794833162 @default.
- W4320491388 cites W2801763052 @default.
- W4320491388 cites W2889234747 @default.
- W4320491388 cites W2905177566 @default.
- W4320491388 cites W2911187921 @default.
- W4320491388 cites W2918662515 @default.
- W4320491388 cites W2961898694 @default.
- W4320491388 cites W2963147943 @default.
- W4320491388 cites W2973963952 @default.
- W4320491388 cites W2991453980 @default.
- W4320491388 cites W2995190362 @default.
- W4320491388 cites W2995222714 @default.
- W4320491388 cites W3006012411 @default.
- W4320491388 cites W3011979387 @default.
- W4320491388 cites W3012576217 @default.
- W4320491388 cites W3021053184 @default.
- W4320491388 cites W3023197304 @default.
- W4320491388 cites W3045265118 @default.
- W4320491388 cites W3059233071 @default.
- W4320491388 cites W3093351495 @default.
- W4320491388 cites W3093878129 @default.
- W4320491388 cites W3111143057 @default.
- W4320491388 cites W3135229876 @default.
- W4320491388 cites W3136654927 @default.
- W4320491388 cites W3153668192 @default.
- W4320491388 cites W3154889217 @default.
- W4320491388 cites W3156652064 @default.
- W4320491388 cites W3159541917 @default.
- W4320491388 cites W3159598422 @default.
- W4320491388 cites W3175910967 @default.
- W4320491388 cites W3187331107 @default.
- W4320491388 cites W3196775031 @default.
- W4320491388 cites W3200728597 @default.
- W4320491388 cites W3211876735 @default.
- W4320491388 cites W3215959508 @default.
- W4320491388 cites W4200025659 @default.
- W4320491388 cites W4200391200 @default.
- W4320491388 cites W4211044101 @default.
- W4320491388 cites W4225262656 @default.
- W4320491388 cites W4283388754 @default.
- W4320491388 cites W4283465314 @default.
- W4320491388 cites W4285086539 @default.
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- W4320491388 doi "https://doi.org/10.3390/nu15040930" @default.
- W4320491388 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36839287" @default.
- W4320491388 hasPublicationYear "2023" @default.
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