Matches in SemOpenAlex for { <https://semopenalex.org/work/W4320492007> ?p ?o ?g. }
- W4320492007 endingPage "465" @default.
- W4320492007 startingPage "465" @default.
- W4320492007 abstract "Fruit and leaf cuticular waxes are valuable source materials for the isolation of triterpenoids that can be applied as natural antioxidants and anticancer agents. The present study aimed at the semi-preparative fractionation of triterpenoids from cuticular wax extracts of Vaccinium vitis-idaea L. (lingonberry) leaves and fruits and the evaluation of their cytotoxic potential. Qualitative and quantitative characterization of obtained extracts and triterpenoid fractions was performed using HPLC-PDA method, followed by complementary analysis by GC-MS. For each fraction, cytotoxic activities towards the human colon adenocarcinoma cell line (HT-29), malignant melanoma cell line (IGR39), clear renal carcinoma cell line (CaKi-1), and normal endothelial cells (EC) were determined using MTT assay. Furthermore, the effect of the most promising samples on cancer spheroid growth and viability was examined. This study allowed us to confirm that particular triterpenoid mixtures from lingonberry waxes may possess stronger cytotoxic activities than crude unpurified extracts. Fractions containing triterpenoid acids plus fernenol, complexes of oleanolic:ursolic acids, and erythrodiol:uvaol were found to be the most potent therapeutic candidates in the management of cancer diseases. The specificity of cuticular wax extracts of lingonberry leaves and fruits, leading to different purity and anticancer potential of obtained counterpart fractions, was also enclosed. These findings contribute to the profitable utilization of lingonberry cuticular waxes and provide considerable insights into the anticancer effects of particular triterpenoids and pharmacological interactions." @default.
- W4320492007 created "2023-02-14" @default.
- W4320492007 creator A5000375951 @default.
- W4320492007 creator A5022946928 @default.
- W4320492007 creator A5033902062 @default.
- W4320492007 creator A5046505701 @default.
- W4320492007 creator A5079553101 @default.
- W4320492007 creator A5086251972 @default.
- W4320492007 date "2023-02-12" @default.
- W4320492007 modified "2023-10-17" @default.
- W4320492007 title "Fractionation and Characterization of Triterpenoids from Vaccinium vitis-idaea L. Cuticular Waxes and Their Potential as Anticancer Agents" @default.
- W4320492007 cites W1968659809 @default.
- W4320492007 cites W1979823029 @default.
- W4320492007 cites W1980855672 @default.
- W4320492007 cites W1987373455 @default.
- W4320492007 cites W1990794351 @default.
- W4320492007 cites W1993046616 @default.
- W4320492007 cites W2006539642 @default.
- W4320492007 cites W2007370292 @default.
- W4320492007 cites W2009415678 @default.
- W4320492007 cites W2013816495 @default.
- W4320492007 cites W2014227653 @default.
- W4320492007 cites W2019873533 @default.
- W4320492007 cites W2021194666 @default.
- W4320492007 cites W2040033806 @default.
- W4320492007 cites W2054794298 @default.
- W4320492007 cites W2063319215 @default.
- W4320492007 cites W2067780633 @default.
- W4320492007 cites W2068080664 @default.
- W4320492007 cites W2078448804 @default.
- W4320492007 cites W2092588275 @default.
- W4320492007 cites W2106347289 @default.
- W4320492007 cites W2137634849 @default.
- W4320492007 cites W2240093536 @default.
- W4320492007 cites W2323947639 @default.
- W4320492007 cites W2328374991 @default.
- W4320492007 cites W2330877079 @default.
- W4320492007 cites W2413398485 @default.
- W4320492007 cites W2554249780 @default.
- W4320492007 cites W2587788572 @default.
- W4320492007 cites W2591384052 @default.
- W4320492007 cites W2612679083 @default.
- W4320492007 cites W2743665376 @default.
- W4320492007 cites W2773347677 @default.
- W4320492007 cites W2795681973 @default.
- W4320492007 cites W2805114240 @default.
- W4320492007 cites W2810198609 @default.
- W4320492007 cites W2884253584 @default.
- W4320492007 cites W2893578377 @default.
- W4320492007 cites W2909024861 @default.
- W4320492007 cites W2922225701 @default.
- W4320492007 cites W2945146450 @default.
- W4320492007 cites W2964247574 @default.
- W4320492007 cites W2982121845 @default.
- W4320492007 cites W2989033661 @default.
- W4320492007 cites W2990454686 @default.
- W4320492007 cites W2997885325 @default.
- W4320492007 cites W3020879449 @default.
- W4320492007 cites W3046572700 @default.
- W4320492007 cites W3085705617 @default.
- W4320492007 cites W3094998433 @default.
- W4320492007 cites W3110714547 @default.
- W4320492007 cites W3110855416 @default.
- W4320492007 cites W3111668202 @default.
- W4320492007 cites W3116682523 @default.
- W4320492007 cites W3119791701 @default.
- W4320492007 cites W3122678636 @default.
- W4320492007 cites W3139268435 @default.
- W4320492007 cites W3139456761 @default.
- W4320492007 cites W3163520986 @default.
- W4320492007 cites W3170132729 @default.
- W4320492007 cites W3178617647 @default.
- W4320492007 cites W3190887190 @default.
- W4320492007 cites W3200539295 @default.
- W4320492007 cites W3205325783 @default.
- W4320492007 cites W3210938868 @default.
- W4320492007 cites W4200252975 @default.
- W4320492007 cites W4200576897 @default.
- W4320492007 cites W4206380805 @default.
- W4320492007 cites W4210793692 @default.
- W4320492007 cites W4214636279 @default.
- W4320492007 cites W4214920424 @default.
- W4320492007 cites W4221008568 @default.
- W4320492007 cites W4221040622 @default.
- W4320492007 cites W4282001003 @default.
- W4320492007 cites W4285013205 @default.
- W4320492007 cites W4292136401 @default.
- W4320492007 cites W4292380346 @default.
- W4320492007 cites W4292554430 @default.
- W4320492007 cites W4294308001 @default.
- W4320492007 cites W4295886831 @default.
- W4320492007 cites W4298111406 @default.
- W4320492007 cites W4304196273 @default.
- W4320492007 cites W4309934750 @default.
- W4320492007 doi "https://doi.org/10.3390/antiox12020465" @default.
- W4320492007 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36830023" @default.
- W4320492007 hasPublicationYear "2023" @default.
- W4320492007 type Work @default.