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- W4320492097 abstract "Matrix metalloproteinases (MMPs) are endopeptidases participating in physiological processes of the brain, maintaining the blood-brain barrier integrity and playing a critical role in cerebral ischemia. In the acute phase of stroke activity, the expression of MMPs increase and is associated with adverse effects, but in the post-stroke phase, MMPs contribute to the process of healing by remodeling tissue lesions. The imbalance between MMPs and their inhibitors results in excessive fibrosis associated with the enhanced risk of atrial fibrillation (AF), which is the main cause of cardioembolic strokes. MMPs activity disturbances were observed in the development of hypertension, diabetes, heart failure and vascular disease enclosed in CHA2DS2VASc score, the scale commonly used to evaluate the risk of thromboembolic complications risk in AF patients. MMPs involved in hemorrhagic complications of stroke and activated by reperfusion therapy may also worsen the stroke outcome. In the present review, we briefly summarize the role of MMPs in the ischemic stroke with particular consideration of the cardioembolic stroke and its complications. Moreover, we discuss the genetic background, regulation pathways, clinical risk factors and impact of MMPs on the clinical outcome." @default.
- W4320492097 created "2023-02-14" @default.
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- W4320492097 creator A5042935968 @default.
- W4320492097 creator A5053821652 @default.
- W4320492097 creator A5066812296 @default.
- W4320492097 date "2023-02-11" @default.
- W4320492097 modified "2023-09-30" @default.
- W4320492097 title "Matrix Metalloproteinases in Cardioembolic Stroke: From Background to Complications" @default.
- W4320492097 cites W100631648 @default.
- W4320492097 cites W113129998 @default.
- W4320492097 cites W1163198320 @default.
- W4320492097 cites W1508955537 @default.
- W4320492097 cites W1533718157 @default.
- W4320492097 cites W1534181866 @default.
- W4320492097 cites W1537821126 @default.
- W4320492097 cites W1540258377 @default.
- W4320492097 cites W1545436192 @default.
- W4320492097 cites W1545606956 @default.
- W4320492097 cites W1555380614 @default.
- W4320492097 cites W1568095913 @default.
- W4320492097 cites W1580479524 @default.
- W4320492097 cites W1621875477 @default.
- W4320492097 cites W1767811926 @default.
- W4320492097 cites W1771562684 @default.
- W4320492097 cites W1845851564 @default.
- W4320492097 cites W1964418702 @default.
- W4320492097 cites W1965179332 @default.
- W4320492097 cites W1966722847 @default.
- W4320492097 cites W1969095640 @default.
- W4320492097 cites W1971410714 @default.
- W4320492097 cites W1972933415 @default.
- W4320492097 cites W1984578167 @default.
- W4320492097 cites W1985323628 @default.
- W4320492097 cites W1996275946 @default.
- W4320492097 cites W1997826997 @default.
- W4320492097 cites W1998169155 @default.
- W4320492097 cites W1998954104 @default.
- W4320492097 cites W2000116995 @default.
- W4320492097 cites W2000132670 @default.
- W4320492097 cites W2001128177 @default.
- W4320492097 cites W2002536490 @default.
- W4320492097 cites W2002771508 @default.
- W4320492097 cites W2004837613 @default.
- W4320492097 cites W2006835279 @default.
- W4320492097 cites W2008772954 @default.
- W4320492097 cites W2010254599 @default.
- W4320492097 cites W2011181136 @default.
- W4320492097 cites W2012162957 @default.
- W4320492097 cites W2012575420 @default.
- W4320492097 cites W2017172546 @default.
- W4320492097 cites W2018304272 @default.
- W4320492097 cites W2018358973 @default.
- W4320492097 cites W2018409191 @default.
- W4320492097 cites W2020504623 @default.
- W4320492097 cites W2022030265 @default.
- W4320492097 cites W2023250693 @default.
- W4320492097 cites W2025066195 @default.
- W4320492097 cites W2026044536 @default.
- W4320492097 cites W2033358912 @default.
- W4320492097 cites W2034529849 @default.
- W4320492097 cites W2034752268 @default.
- W4320492097 cites W2036043627 @default.
- W4320492097 cites W2036489895 @default.
- W4320492097 cites W2037072711 @default.
- W4320492097 cites W2037786647 @default.
- W4320492097 cites W2038844856 @default.
- W4320492097 cites W2040400232 @default.
- W4320492097 cites W2047937867 @default.
- W4320492097 cites W2048047884 @default.
- W4320492097 cites W2049925123 @default.
- W4320492097 cites W2051617804 @default.
- W4320492097 cites W2052532310 @default.
- W4320492097 cites W2057527114 @default.
- W4320492097 cites W2061443460 @default.
- W4320492097 cites W2063007450 @default.
- W4320492097 cites W2064023379 @default.
- W4320492097 cites W2065745631 @default.
- W4320492097 cites W2067140660 @default.
- W4320492097 cites W2067395123 @default.
- W4320492097 cites W2069990241 @default.
- W4320492097 cites W2071848052 @default.
- W4320492097 cites W2072518602 @default.
- W4320492097 cites W2074809224 @default.
- W4320492097 cites W2080051897 @default.
- W4320492097 cites W2082870917 @default.
- W4320492097 cites W2084419638 @default.
- W4320492097 cites W2084667881 @default.
- W4320492097 cites W2086414747 @default.
- W4320492097 cites W2089817297 @default.
- W4320492097 cites W2091651295 @default.
- W4320492097 cites W2094757280 @default.
- W4320492097 cites W2096316234 @default.
- W4320492097 cites W2097292535 @default.
- W4320492097 cites W2098580296 @default.
- W4320492097 cites W2103420764 @default.
- W4320492097 cites W2103540952 @default.