Matches in SemOpenAlex for { <https://semopenalex.org/work/W4320492741> ?p ?o ?g. }
- W4320492741 endingPage "e14826" @default.
- W4320492741 startingPage "e14826" @default.
- W4320492741 abstract "Podocyte injury is a critical factor in the pathogenesis of diabeticnephropathy (DN). Emerging evidence has demonstrated that breviscapine (Bre) exerts a renoprotective effect on diabetic rats. However, the effects of Bre on regulating podocyte injury under high glucose (HG) conditions remain unclear. In this study, an experimental mouse model of DN was induced by intraperitoneal injections of streptozotocin (STZ) in vivo. The effects of Bre on podocyte injury were assessed using cell counting kit-8 (CCK-8) assay, TdT-mediated dUTPnick-endlabelling (TUNEL) staining, quantitative real-time PCR (qRT‒PCR) and western blot analysis. We found that renal function was significantly decreased in diabetic mice, and this effect was blocked by Bre treatment. Bre effectively increased podocyte viability and inhibited HG-induced cell apoptosis. Furthermore, Bre ameliorated HG-induced podocyte injury, as evidenced by decreased α-smooth muscle actin (α-SMA) expression and increased podocin and synaptopodin expression. Mechanistically, Bre inhibited HG-induced nuclear factorkappaB (NF-κB) signalling activation and subsequently decreased NLR family pyrin domain containing 3 (NLRP3) inflammasome activation, resulting in a decrease in pyroptosis. Pharmacological inhibition of NLRP3 decreased HG-induced podocyte injury, whereas the NLRP3 agonist abrogated the effects of Bre on inhibiting podocyte injury. In summary, these results demonstrate that Bre alleviates HG-induced podocyte injury and improves renal function in diabetic mice, at least in part by inhibiting NF-κB/NLRP3-mediated pyroptosis." @default.
- W4320492741 created "2023-02-14" @default.
- W4320492741 creator A5033490386 @default.
- W4320492741 creator A5037820914 @default.
- W4320492741 creator A5044893538 @default.
- W4320492741 creator A5065529872 @default.
- W4320492741 creator A5080042902 @default.
- W4320492741 date "2023-02-13" @default.
- W4320492741 modified "2023-10-13" @default.
- W4320492741 title "Breviscapine alleviates podocyte injury by inhibiting NF-κB/NLRP3-mediated pyroptosis in diabetic nephropathy" @default.
- W4320492741 cites W1864325817 @default.
- W4320492741 cites W1967369910 @default.
- W4320492741 cites W1971915082 @default.
- W4320492741 cites W1994765876 @default.
- W4320492741 cites W2004813950 @default.
- W4320492741 cites W2007378287 @default.
- W4320492741 cites W2035696747 @default.
- W4320492741 cites W2040722201 @default.
- W4320492741 cites W2048032544 @default.
- W4320492741 cites W2060748039 @default.
- W4320492741 cites W2070133934 @default.
- W4320492741 cites W2081706292 @default.
- W4320492741 cites W2085574022 @default.
- W4320492741 cites W2107277218 @default.
- W4320492741 cites W2148820339 @default.
- W4320492741 cites W2157002396 @default.
- W4320492741 cites W2192080449 @default.
- W4320492741 cites W2301340697 @default.
- W4320492741 cites W2350665894 @default.
- W4320492741 cites W2410751619 @default.
- W4320492741 cites W2418806051 @default.
- W4320492741 cites W2473946118 @default.
- W4320492741 cites W2554941534 @default.
- W4320492741 cites W2615714795 @default.
- W4320492741 cites W2735527928 @default.
- W4320492741 cites W2799726777 @default.
- W4320492741 cites W2898306085 @default.
- W4320492741 cites W2978562320 @default.
- W4320492741 cites W3014721260 @default.
- W4320492741 cites W3022051450 @default.
- W4320492741 cites W3041712290 @default.
- W4320492741 cites W3047879827 @default.
- W4320492741 cites W3088162480 @default.
- W4320492741 cites W3102726452 @default.
- W4320492741 cites W3111887908 @default.
- W4320492741 cites W3126399969 @default.
- W4320492741 cites W3149252437 @default.
- W4320492741 cites W3165527106 @default.
- W4320492741 cites W3172277366 @default.
- W4320492741 cites W3181307362 @default.
- W4320492741 cites W3209272185 @default.
- W4320492741 cites W4206608957 @default.
- W4320492741 cites W4206900109 @default.
- W4320492741 cites W4220945818 @default.
- W4320492741 cites W4221062709 @default.
- W4320492741 cites W4236357753 @default.
- W4320492741 cites W4283260970 @default.
- W4320492741 cites W4283731092 @default.
- W4320492741 cites W4283758081 @default.
- W4320492741 cites W4288739215 @default.
- W4320492741 cites W4288886360 @default.
- W4320492741 cites W4289443726 @default.
- W4320492741 cites W4292738921 @default.
- W4320492741 cites W4293124683 @default.
- W4320492741 cites W4294074094 @default.
- W4320492741 cites W4294771161 @default.
- W4320492741 cites W4294904097 @default.
- W4320492741 cites W4297003987 @default.
- W4320492741 doi "https://doi.org/10.7717/peerj.14826" @default.
- W4320492741 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36815984" @default.
- W4320492741 hasPublicationYear "2023" @default.
- W4320492741 type Work @default.
- W4320492741 citedByCount "3" @default.
- W4320492741 countsByYear W43204927412023 @default.
- W4320492741 crossrefType "journal-article" @default.
- W4320492741 hasAuthorship W4320492741A5033490386 @default.
- W4320492741 hasAuthorship W4320492741A5037820914 @default.
- W4320492741 hasAuthorship W4320492741A5044893538 @default.
- W4320492741 hasAuthorship W4320492741A5065529872 @default.
- W4320492741 hasAuthorship W4320492741A5080042902 @default.
- W4320492741 hasBestOaLocation W43204927411 @default.
- W4320492741 hasConcept C104317684 @default.
- W4320492741 hasConcept C126322002 @default.
- W4320492741 hasConcept C134018914 @default.
- W4320492741 hasConcept C139174496 @default.
- W4320492741 hasConcept C170493617 @default.
- W4320492741 hasConcept C17172800 @default.
- W4320492741 hasConcept C185592680 @default.
- W4320492741 hasConcept C190283241 @default.
- W4320492741 hasConcept C196795494 @default.
- W4320492741 hasConcept C2776415932 @default.
- W4320492741 hasConcept C2776855237 @default.
- W4320492741 hasConcept C2777146197 @default.
- W4320492741 hasConcept C2777209026 @default.
- W4320492741 hasConcept C2779280383 @default.
- W4320492741 hasConcept C2779561371 @default.
- W4320492741 hasConcept C2779922275 @default.
- W4320492741 hasConcept C2780091579 @default.