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- W4320494313 abstract "Cancer development follows an evolutionary pattern of “mutation-selection-adaptation” detailed by Cancer Evolution and Development (Cancer Evo-Dev), a theory that represents a process of accumulating somatic mutations due to the imbalance between the mutation-promoting force and the mutation-repairing force and retro-differentiation of the mutant cells to cancer initiation cells in a chronic inflammatory microenvironment. The fragile histidine triad (FHIT) gene is a tumor suppressor gene whose expression is often reduced or inactivated in precancerous lesions during chronic inflammation or virus-induced replicative stress. Here, we summarize evidence regarding the mechanisms by which the FHIT is inactivated in cancer, including the loss of heterozygosity and the promoter methylation, and characterizes the role of the FHIT in bridging macroevolution and microevolution and in facilitating retro-differentiation during cancer evolution and development. It is suggested that decreased FHIT expression is involved in several critical steps of Cancer Evo-Dev. Future research needs to focus on the role and mechanisms of the FHIT in promoting the transformation of pre-cancerous lesions into cancer." @default.
- W4320494313 created "2023-02-14" @default.
- W4320494313 creator A5015652657 @default.
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- W4320494313 creator A5064440239 @default.
- W4320494313 creator A5072964389 @default.
- W4320494313 creator A5083466095 @default.
- W4320494313 date "2023-02-10" @default.
- W4320494313 modified "2023-10-15" @default.
- W4320494313 title "Potential Role of the Fragile Histidine Triad in Cancer Evo-Dev" @default.
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