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• W4320496831 abstract "ABSTRACT In Schizosaccharomyces pombe, ecl family genes are induced by several signals, such as starvation of various nutrients, including sulfur, amino acids and Mg2+, and environmental stress, including heat or oxidative stress. These genes mediate appropriate cellular responses and contribute to the maintenance of cell viability and induction of sexual differentiation. Although this yeast has three ecl family genes with overlapping functions, any environmental conditions that induce ecl3+ remain unidentified. We demonstrate that ecl3+ is induced by phosphate starvation, similar to its chromosomally neighboring genes, pho1+ and pho84+, which respectively encode an extracellular acid phosphatase and an inorganic phosphate transporter. ecl3+ expression was induced by the transcription factor Pho7 and affected by the cyclin-dependent kinase (CDK)-activating kinase Csk1. Phosphate starvation induced G1 arrest and sexual differentiation via ecl family genes. Biochemical analyses suggested that this G1 arrest was mediated by the stabilization of the CDK inhibitor Rum1, which was dependent on ecl family genes. This study shows that ecl family genes are required for appropriate responses to phosphate starvation and provides novel insights into the diversity and similarity of starvation responses." @default.
• W4320496831 created "2023-02-14" @default.
• W4320496831 creator A5008644051 @default.
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• W4320496831 creator A5044606274 @default.
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• W4320496831 creator A5073384075 @default.
• W4320496831 creator A5079145594 @default.
• W4320496831 creator A5088435354 @default.
• W4320496831 date "2023-03-10" @default.
• W4320496831 modified "2023-10-14" @default.
• W4320496831 title "The <i>ecl</i> family gene <i>ecl3</i>+ is induced by phosphate starvation and contributes to sexual differentiation in fission yeast" @default.
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