FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4320507099> ?p ?o ?g. }

• W4320507099 endingPage "945" @default.
• W4320507099 startingPage "933" @default.
• W4320507099 abstract "Abstract Objectives To compare the long-term risk of treatment failure of dolutegravir-based ART in men and women in a real-life setting. Patients and methods Persons living with HIV (PLWH) from the ICONA cohort were included if they had started dolutegravir in a two- or three-drug regimen as ART-naive or as virologically controlled ART-experienced. The primary endpoint was time to treatment failure (virological/clinical failure or dolutegravir discontinuation). Secondary endpoints were: time to dolutegravir discontinuation due to toxicity and to neuropsychiatric adverse events; and time to virological failure. Cox regression analyses focused on differences in outcomes by sex. Results A total of 2304 PLWH (15% women) initiated dolutegravir-based therapy from ART-naive, and 1916 (19.8% women) while experienced. After a median follow-up of 2.2 (IQR: 0.9–3.9) years in ART-naive and 2.4 (IQR: 1.1–4.3) years in experienced, the 4-year cumulative probability of treatment failure was 33% (95% CI 30.5–35.1) and 20% (95% CI 17.8–22.3), respectively. In the multivariable analyses, in ART-naive the risk of treatment failure was higher for women, but not different after excluding women discontinuing dolutegravir for pregnancy concerns. We also observed a higher risk of discontinuation for toxicity in women (ART-naives: Adjusted Hazard Ratio (AHR): 1.56%; 95% CI: 1.03–2.37; ART-experienced: AHR: 1.53%; 95% CI: 1.01–2.32), although the absolute 4-year probability was low: 7.7% (95% CI 6.5–9.2) in ART-naive and 8.3% (95% CI 6.9–9.9) in experienced. Conclusions In our cohort of PLWH treated with dolutegravir-based regimens and followed up for up to 4 years, we observed a low risk of treatment failure and no evidence for a difference by sex, after excluding discontinuation due to pregnancy concerns. However, we observed a higher risk of dolutegravir discontinuation for toxicity in women." @default.
• W4320507099 created "2023-02-14" @default.
• W4320507099 creator A5001547379 @default.
• W4320507099 creator A5008126184 @default.
• W4320507099 creator A5010288279 @default.
• W4320507099 creator A5011090514 @default.
• W4320507099 creator A5012377940 @default.
• W4320507099 creator A5020821264 @default.
• W4320507099 creator A5029858425 @default.
• W4320507099 creator A5044171804 @default.
• W4320507099 creator A5047438814 @default.
• W4320507099 creator A5078701955 @default.
• W4320507099 creator A5079950860 @default.
• W4320507099 creator A5081103796 @default.
• W4320507099 date "2023-02-13" @default.
• W4320507099 modified "2023-10-06" @default.
• W4320507099 title "Long-term outcome of dolutegravir-containing regimens according to sex: data from the ICONA study" @default.
• W4320507099 cites W1985646480 @default.
• W4320507099 cites W2070358502 @default.
• W4320507099 cites W2088712676 @default.
• W4320507099 cites W2094241860 @default.
• W4320507099 cites W2163256722 @default.
• W4320507099 cites W2554692247 @default.
• W4320507099 cites W2573307309 @default.
• W4320507099 cites W2728117782 @default.
• W4320507099 cites W2735301415 @default.
• W4320507099 cites W2913317838 @default.
• W4320507099 cites W2914789356 @default.
• W4320507099 cites W2963164305 @default.
• W4320507099 cites W3000369307 @default.
• W4320507099 cites W3043617471 @default.
• W4320507099 cites W3115608519 @default.
• W4320507099 cites W3142355365 @default.
• W4320507099 cites W3199668003 @default.
• W4320507099 cites W4207018194 @default.
• W4320507099 doi "https://doi.org/10.1093/jac/dkad026" @default.
• W4320507099 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36775983" @default.
• W4320507099 hasPublicationYear "2023" @default.
• W4320507099 type Work @default.
• W4320507099 citedByCount "2" @default.
• W4320507099 countsByYear W43205070992023 @default.
• W4320507099 crossrefType "journal-article" @default.
• W4320507099 hasAuthorship W4320507099A5001547379 @default.
• W4320507099 hasAuthorship W4320507099A5008126184 @default.
• W4320507099 hasAuthorship W4320507099A5010288279 @default.
• W4320507099 hasAuthorship W4320507099A5011090514 @default.
• W4320507099 hasAuthorship W4320507099A5012377940 @default.
• W4320507099 hasAuthorship W4320507099A5020821264 @default.
• W4320507099 hasAuthorship W4320507099A5029858425 @default.
• W4320507099 hasAuthorship W4320507099A5044171804 @default.
• W4320507099 hasAuthorship W4320507099A5047438814 @default.
• W4320507099 hasAuthorship W4320507099A5078701955 @default.
• W4320507099 hasAuthorship W4320507099A5079950860 @default.
• W4320507099 hasAuthorship W4320507099A5081103796 @default.
• W4320507099 hasConcept C126322002 @default.
• W4320507099 hasConcept C142462285 @default.
• W4320507099 hasConcept C197934379 @default.
• W4320507099 hasConcept C203014093 @default.
• W4320507099 hasConcept C207103383 @default.
• W4320507099 hasConcept C2778715236 @default.
• W4320507099 hasConcept C2779502633 @default.
• W4320507099 hasConcept C2781413609 @default.
• W4320507099 hasConcept C2993143319 @default.
• W4320507099 hasConcept C3013748606 @default.
• W4320507099 hasConcept C44249647 @default.
• W4320507099 hasConcept C50382708 @default.
• W4320507099 hasConcept C71924100 @default.
• W4320507099 hasConcept C72563966 @default.
• W4320507099 hasConcept C88879693 @default.
• W4320507099 hasConceptScore W4320507099C126322002 @default.
• W4320507099 hasConceptScore W4320507099C142462285 @default.
• W4320507099 hasConceptScore W4320507099C197934379 @default.
• W4320507099 hasConceptScore W4320507099C203014093 @default.
• W4320507099 hasConceptScore W4320507099C207103383 @default.
• W4320507099 hasConceptScore W4320507099C2778715236 @default.
• W4320507099 hasConceptScore W4320507099C2779502633 @default.
• W4320507099 hasConceptScore W4320507099C2781413609 @default.
• W4320507099 hasConceptScore W4320507099C2993143319 @default.
• W4320507099 hasConceptScore W4320507099C3013748606 @default.
• W4320507099 hasConceptScore W4320507099C44249647 @default.
• W4320507099 hasConceptScore W4320507099C50382708 @default.
• W4320507099 hasConceptScore W4320507099C71924100 @default.
• W4320507099 hasConceptScore W4320507099C72563966 @default.
• W4320507099 hasConceptScore W4320507099C88879693 @default.
• W4320507099 hasIssue "4" @default.
• W4320507099 hasLocation W43205070991 @default.
• W4320507099 hasLocation W43205070992 @default.
• W4320507099 hasOpenAccess W4320507099 @default.
• W4320507099 hasPrimaryLocation W43205070991 @default.
• W4320507099 hasRelatedWork W2024084134 @default.
• W4320507099 hasRelatedWork W2085208618 @default.
• W4320507099 hasRelatedWork W2528919078 @default.
• W4320507099 hasRelatedWork W2554692247 @default.
• W4320507099 hasRelatedWork W2608989554 @default.
• W4320507099 hasRelatedWork W2831487285 @default.
• W4320507099 hasRelatedWork W4254658616 @default.
• W4320507099 hasRelatedWork W4320507099 @default.
• W4320507099 hasRelatedWork W4362546065 @default.

• next