Matches in SemOpenAlex for { <https://semopenalex.org/work/W4320507407> ?p ?o ?g. }
- W4320507407 endingPage "104" @default.
- W4320507407 startingPage "86" @default.
- W4320507407 abstract "Phosphatase and tensin homolog (PTEN) is one of the most important tumor suppressor genes. Although studies have shown the association between cancer and genetic polymorphisms of PTEN, the underlying molecular mechanisms of breast cancer (BC) chemosensitivity that results from PTEN polymorphism is still unclear. This study aims to investigate potential links between PTEN polymorphisms in cis-regulatory elements and BC chemosensitivity in the Chinese population. A total of 172 BC patients who received neoadjuvant chemotherapy were included in the study, including 104 chemosensitive cases and 68 chemoresistant cases. The results showed a significant association between the rs786204926 polymorphism and BC chemosensitivity. Logistic multivariate regression analysis showed that age, lymph node metastasis, and the rs786204926 genotype were risk factors for BC chemoresistance. The G allele of rs786204926 is more prone to increasing the risk of chemosensitivity in BC. Additionally, analysis using Alamut Visual showed a preference of the G allele of rs786204926 to produce a novel PTEN mutant with an insertion of 18 bases from intron 4. While the transcriptional level of PTEN remained similar in chemosensitivity and chemoresistant samples, its protein level changed significantly. Interestingly, there were significant differences in both transcription and protein levels of the novel PTEN mutant between the two groups. Furthermore, we found that the mutant was more susceptible to dephosphorylation compared with wildtype PTEN, leading to chemosensitivity through the PI3K-AKT signaling pathway. These findings indicate that novel PTEN mutants caused by polymorphisms in cis-regulatory elements may be involved in BC chemosensitivity." @default.
- W4320507407 created "2023-02-14" @default.
- W4320507407 creator A5009338775 @default.
- W4320507407 creator A5013204538 @default.
- W4320507407 creator A5028021915 @default.
- W4320507407 creator A5031574868 @default.
- W4320507407 creator A5037677450 @default.
- W4320507407 creator A5039252463 @default.
- W4320507407 creator A5048639505 @default.
- W4320507407 creator A5050723387 @default.
- W4320507407 creator A5060259824 @default.
- W4320507407 creator A5068573197 @default.
- W4320507407 creator A5091074428 @default.
- W4320507407 date "2023-01-01" @default.
- W4320507407 modified "2023-09-26" @default.
- W4320507407 title "A novel PTEN mutant caused by polymorphism in cis-regulatory elements is involved in chemosensitivity in breast cancer." @default.
- W4320507407 cites W1551696649 @default.
- W4320507407 cites W1939083266 @default.
- W4320507407 cites W1969391810 @default.
- W4320507407 cites W1984418041 @default.
- W4320507407 cites W2002294634 @default.
- W4320507407 cites W2019607817 @default.
- W4320507407 cites W2030447006 @default.
- W4320507407 cites W2037203239 @default.
- W4320507407 cites W2038553774 @default.
- W4320507407 cites W2042619042 @default.
- W4320507407 cites W2063318299 @default.
- W4320507407 cites W2066377591 @default.
- W4320507407 cites W2074764208 @default.
- W4320507407 cites W2076203883 @default.
- W4320507407 cites W2079861630 @default.
- W4320507407 cites W2094957750 @default.
- W4320507407 cites W2096534887 @default.
- W4320507407 cites W2103047784 @default.
- W4320507407 cites W2108068107 @default.
- W4320507407 cites W2109559424 @default.
- W4320507407 cites W2113328185 @default.
- W4320507407 cites W2114843025 @default.
- W4320507407 cites W2118263932 @default.
- W4320507407 cites W2118700241 @default.
- W4320507407 cites W2122230708 @default.
- W4320507407 cites W2149441684 @default.
- W4320507407 cites W2150645882 @default.
- W4320507407 cites W2157118246 @default.
- W4320507407 cites W2208499650 @default.
- W4320507407 cites W2308408790 @default.
- W4320507407 cites W2321600639 @default.
- W4320507407 cites W2590380080 @default.
- W4320507407 cites W2600686170 @default.
- W4320507407 cites W2728962997 @default.
- W4320507407 cites W2752551813 @default.
- W4320507407 cites W2766752884 @default.
- W4320507407 cites W2772005237 @default.
- W4320507407 cites W2772375510 @default.
- W4320507407 cites W2779217651 @default.
- W4320507407 cites W2781525129 @default.
- W4320507407 cites W2799510874 @default.
- W4320507407 cites W2801649691 @default.
- W4320507407 cites W2803826431 @default.
- W4320507407 cites W2901391666 @default.
- W4320507407 cites W2915939009 @default.
- W4320507407 cites W2924680674 @default.
- W4320507407 cites W2961255872 @default.
- W4320507407 cites W2966296683 @default.
- W4320507407 cites W2969748831 @default.
- W4320507407 cites W2977214438 @default.
- W4320507407 cites W2981406306 @default.
- W4320507407 cites W2982533528 @default.
- W4320507407 cites W3000239131 @default.
- W4320507407 cites W3009624553 @default.
- W4320507407 cites W3018771626 @default.
- W4320507407 cites W3021867877 @default.
- W4320507407 cites W3036334626 @default.
- W4320507407 cites W3090913075 @default.
- W4320507407 cites W3110506885 @default.
- W4320507407 cites W3166688923 @default.
- W4320507407 cites W3169774451 @default.
- W4320507407 cites W3173627210 @default.
- W4320507407 cites W3193227997 @default.
- W4320507407 cites W3196979618 @default.
- W4320507407 cites W3211446888 @default.
- W4320507407 cites W4200590287 @default.
- W4320507407 cites W4243930828 @default.
- W4320507407 cites W4281635839 @default.
- W4320507407 cites W4287485429 @default.
- W4320507407 cites W4287485565 @default.
- W4320507407 cites W4206884930 @default.
- W4320507407 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36777516" @default.
- W4320507407 hasPublicationYear "2023" @default.
- W4320507407 type Work @default.
- W4320507407 citedByCount "0" @default.
- W4320507407 crossrefType "journal-article" @default.
- W4320507407 hasAuthorship W4320507407A5009338775 @default.
- W4320507407 hasAuthorship W4320507407A5013204538 @default.
- W4320507407 hasAuthorship W4320507407A5028021915 @default.
- W4320507407 hasAuthorship W4320507407A5031574868 @default.
- W4320507407 hasAuthorship W4320507407A5037677450 @default.
- W4320507407 hasAuthorship W4320507407A5039252463 @default.