Matches in SemOpenAlex for { <https://semopenalex.org/work/W4320712575> ?p ?o ?g. }
- W4320712575 endingPage "11" @default.
- W4320712575 startingPage "1" @default.
- W4320712575 abstract "Background/Aim. Thyroid hormone receptor-β (THR-β) agonists play crucial roles in dyslipidemia and metabolic associated fatty liver disease (MAFLD). We developed a novel oral and liver-targeted THR-β agonist, CS27109, and evaluated its efficacy in the treatment of metabolic disorders. Materials and Methods. We evaluated in vitro and in vivo efficacy and/or safety of CS27109 along with MGL3196 (a phase III THR-β agonist). Results. CS27109 showed pronounced activity and selectivity to THR-β and favorable PK properties, which was equivalent to MGL3196. In the hamster model, animals treated with a high dose of CS27109 showed equivalent reductions in serum TC and LDL-c with groups treated with MGL3196. In the rat model, CS27109 and MGL3196 reduced serum ALT, TC, TG, LDL-c, liver weight ratio, and liver steatosis. CS27109 simultaneously decreased liver TG and TC, and MGL3196 additionally reduced AST. In the mouse model, CS27109 dose-dependently reduced serum AST, ALT, liver inflammation, and NAS score, and also downregulated TC, LDL-c, liver steatosis, and fibrosis, but not in a dose-dependent manner. MGL3196 revealed an equivalent effect with CS27109 in that model. CS27109 also exhibited tolerable toxicity to the heart. Conclusions. CS27109 shows comparative in vitro and in vivo efficacy with MGL3196, suggesting its potential therapeutic application in the treatment of MAFLD such as dyslipidemia and steatohepatitis." @default.
- W4320712575 created "2023-02-15" @default.
- W4320712575 creator A5002274959 @default.
- W4320712575 creator A5006807556 @default.
- W4320712575 creator A5023427032 @default.
- W4320712575 creator A5035282947 @default.
- W4320712575 creator A5038920560 @default.
- W4320712575 creator A5040661634 @default.
- W4320712575 creator A5046597133 @default.
- W4320712575 creator A5052441498 @default.
- W4320712575 creator A5064636858 @default.
- W4320712575 creator A5074420124 @default.
- W4320712575 creator A5081609248 @default.
- W4320712575 creator A5085656751 @default.
- W4320712575 date "2023-02-14" @default.
- W4320712575 modified "2023-10-17" @default.
- W4320712575 title "CS27109, A Selective Thyroid Hormone Receptor-β Agonist Alleviates Metabolic-Associated Fatty Liver Disease in Murine Models" @default.
- W4320712575 cites W1982566905 @default.
- W4320712575 cites W2029473474 @default.
- W4320712575 cites W2067740038 @default.
- W4320712575 cites W2100049277 @default.
- W4320712575 cites W2133311535 @default.
- W4320712575 cites W2154619079 @default.
- W4320712575 cites W2253667517 @default.
- W4320712575 cites W2325544658 @default.
- W4320712575 cites W2332383213 @default.
- W4320712575 cites W2566542468 @default.
- W4320712575 cites W2619337392 @default.
- W4320712575 cites W2759997926 @default.
- W4320712575 cites W2767233119 @default.
- W4320712575 cites W2790198401 @default.
- W4320712575 cites W2811157396 @default.
- W4320712575 cites W2839544824 @default.
- W4320712575 cites W2897956494 @default.
- W4320712575 cites W2949146466 @default.
- W4320712575 cites W2962815903 @default.
- W4320712575 cites W2966416367 @default.
- W4320712575 cites W2966600595 @default.
- W4320712575 cites W3004644667 @default.
- W4320712575 cites W3047566174 @default.
- W4320712575 cites W3056055654 @default.
- W4320712575 cites W3092194487 @default.
- W4320712575 cites W3099597731 @default.
- W4320712575 cites W3126426221 @default.
- W4320712575 cites W3133899324 @default.
- W4320712575 cites W3153867501 @default.
- W4320712575 cites W3154897461 @default.
- W4320712575 cites W3173379782 @default.
- W4320712575 cites W3173984559 @default.
- W4320712575 cites W3181862153 @default.
- W4320712575 cites W4200227405 @default.
- W4320712575 cites W4220908409 @default.
- W4320712575 cites W4280641167 @default.
- W4320712575 cites W4281652392 @default.
- W4320712575 cites W4291168597 @default.
- W4320712575 cites W4317521217 @default.
- W4320712575 doi "https://doi.org/10.1155/2023/4950597" @default.
- W4320712575 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36825196" @default.
- W4320712575 hasPublicationYear "2023" @default.
- W4320712575 type Work @default.
- W4320712575 citedByCount "1" @default.
- W4320712575 countsByYear W43207125752023 @default.
- W4320712575 crossrefType "journal-article" @default.
- W4320712575 hasAuthorship W4320712575A5002274959 @default.
- W4320712575 hasAuthorship W4320712575A5006807556 @default.
- W4320712575 hasAuthorship W4320712575A5023427032 @default.
- W4320712575 hasAuthorship W4320712575A5035282947 @default.
- W4320712575 hasAuthorship W4320712575A5038920560 @default.
- W4320712575 hasAuthorship W4320712575A5040661634 @default.
- W4320712575 hasAuthorship W4320712575A5046597133 @default.
- W4320712575 hasAuthorship W4320712575A5052441498 @default.
- W4320712575 hasAuthorship W4320712575A5064636858 @default.
- W4320712575 hasAuthorship W4320712575A5074420124 @default.
- W4320712575 hasAuthorship W4320712575A5081609248 @default.
- W4320712575 hasAuthorship W4320712575A5085656751 @default.
- W4320712575 hasBestOaLocation W43207125751 @default.
- W4320712575 hasConcept C126322002 @default.
- W4320712575 hasConcept C134018914 @default.
- W4320712575 hasConcept C150903083 @default.
- W4320712575 hasConcept C170493617 @default.
- W4320712575 hasConcept C207001950 @default.
- W4320712575 hasConcept C2776175330 @default.
- W4320712575 hasConcept C2778096610 @default.
- W4320712575 hasConcept C2778772119 @default.
- W4320712575 hasConcept C2778938600 @default.
- W4320712575 hasConcept C2779134260 @default.
- W4320712575 hasConcept C2779478299 @default.
- W4320712575 hasConcept C526584372 @default.
- W4320712575 hasConcept C71924100 @default.
- W4320712575 hasConcept C86803240 @default.
- W4320712575 hasConceptScore W4320712575C126322002 @default.
- W4320712575 hasConceptScore W4320712575C134018914 @default.
- W4320712575 hasConceptScore W4320712575C150903083 @default.
- W4320712575 hasConceptScore W4320712575C170493617 @default.
- W4320712575 hasConceptScore W4320712575C207001950 @default.
- W4320712575 hasConceptScore W4320712575C2776175330 @default.
- W4320712575 hasConceptScore W4320712575C2778096610 @default.
- W4320712575 hasConceptScore W4320712575C2778772119 @default.