FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4320712638> ?p ?o ?g. }

• W4320712638 abstract "Persons with HIV (PWH) on long-term antiretroviral therapy (ART) have a higher incidence and prevalence of cardiometabolic diseases attributed, in part, to persistent inflammation despite viral suppression. In addition to traditional risk factors, immune responses to co-infections such as cytomegalovirus (CMV) may play an unappreciated role in cardiometabolic comorbidities and offer new potential therapeutic targets in a subgroup of individuals. We assessed the relationship of CX3CR1 + , GPR56 + , and CD57 +/- T cells (termed CGC + ) with comorbid conditions in a cohort of 134 PWH co-infected with CMV on long-term ART. We found that PWH with cardiometabolic diseases (non-alcoholic fatty liver disease, calcified coronary arteries, or diabetes) had higher circulating CGC + CD4 + T cells compared to metabolically healthy PWH. The traditional risk factor most correlated with CGC + CD4 + T cell frequency was fasting blood glucose, as well as starch/sucrose metabolites. While unstimulated CGC + CD4 + T cells, like other memory T cells, depend on oxidative phosphorylation for energy, they exhibited higher expression of carnitine palmitoyl transferase 1A compared to other CD4 + T cell subsets, suggesting a potentially greater capacity for fatty acid β-oxidation. Lastly, we show that CMV-specific T cells against multiple viral epitopes are predominantly CGC + . Together, this study suggests that among PWH, CGC + CD4 + T cells are frequently CMV-specific and are associated with diabetes, coronary arterial calcium, and non-alcoholic fatty liver disease. Future studies should assess whether anti-CMV therapies could reduce cardiometabolic disease risk in some individuals." @default.
• W4320712638 created "2023-02-15" @default.
• W4320712638 creator A5003492309 @default.
• W4320712638 creator A5007161076 @default.
• W4320712638 creator A5011627807 @default.
• W4320712638 creator A5013491544 @default.
• W4320712638 creator A5018576802 @default.
• W4320712638 creator A5024209421 @default.
• W4320712638 creator A5029003024 @default.
• W4320712638 creator A5029261402 @default.
• W4320712638 creator A5030863196 @default.
• W4320712638 creator A5060255516 @default.
• W4320712638 creator A5060666271 @default.
• W4320712638 creator A5067647063 @default.
• W4320712638 creator A5068568381 @default.
• W4320712638 creator A5070165631 @default.
• W4320712638 creator A5072844077 @default.
• W4320712638 creator A5077937026 @default.
• W4320712638 creator A5081637691 @default.
• W4320712638 creator A5084307695 @default.
• W4320712638 creator A5085647257 @default.
• W4320712638 creator A5090472520 @default.
• W4320712638 creator A5090564785 @default.
• W4320712638 date "2023-02-14" @default.
• W4320712638 modified "2023-10-03" @default.
• W4320712638 title "CD4+ T cells expressing CX3CR1, GPR56, with variable CD57 are associated with cardiometabolic diseases in persons with HIV" @default.
• W4320712638 cites W1612656617 @default.
• W4320712638 cites W1970441702 @default.
• W4320712638 cites W1976292294 @default.
• W4320712638 cites W1989958005 @default.
• W4320712638 cites W1993094191 @default.
• W4320712638 cites W1993686673 @default.
• W4320712638 cites W1995018144 @default.
• W4320712638 cites W1999421885 @default.
• W4320712638 cites W2002863111 @default.
• W4320712638 cites W2003268139 @default.
• W4320712638 cites W2016652479 @default.
• W4320712638 cites W2017771330 @default.
• W4320712638 cites W2040001681 @default.
• W4320712638 cites W2042761836 @default.
• W4320712638 cites W2049402923 @default.
• W4320712638 cites W2058555166 @default.
• W4320712638 cites W2068767807 @default.
• W4320712638 cites W2070050178 @default.
• W4320712638 cites W2071010503 @default.
• W4320712638 cites W2093974715 @default.
• W4320712638 cites W2096248193 @default.
• W4320712638 cites W2116687125 @default.
• W4320712638 cites W2119722946 @default.
• W4320712638 cites W2126477201 @default.
• W4320712638 cites W2132990407 @default.
• W4320712638 cites W2146614605 @default.
• W4320712638 cites W2158333823 @default.
• W4320712638 cites W2158966732 @default.
• W4320712638 cites W2159360702 @default.
• W4320712638 cites W2160097074 @default.
• W4320712638 cites W2162694378 @default.
• W4320712638 cites W2163782912 @default.
• W4320712638 cites W2171523916 @default.
• W4320712638 cites W2214000744 @default.
• W4320712638 cites W2222815228 @default.
• W4320712638 cites W2283669950 @default.
• W4320712638 cites W2302130729 @default.
• W4320712638 cites W2336908092 @default.
• W4320712638 cites W2343060625 @default.
• W4320712638 cites W2345356016 @default.
• W4320712638 cites W2510733431 @default.
• W4320712638 cites W2587884031 @default.
• W4320712638 cites W2616834435 @default.
• W4320712638 cites W2763398558 @default.
• W4320712638 cites W2789275404 @default.
• W4320712638 cites W2801330967 @default.
• W4320712638 cites W2818595586 @default.
• W4320712638 cites W2885525933 @default.
• W4320712638 cites W2887841289 @default.
• W4320712638 cites W2904634089 @default.
• W4320712638 cites W2922459540 @default.
• W4320712638 cites W2923258631 @default.
• W4320712638 cites W2924715006 @default.
• W4320712638 cites W2948123223 @default.
• W4320712638 cites W2952820718 @default.
• W4320712638 cites W2990398036 @default.
• W4320712638 cites W3013245257 @default.
• W4320712638 cites W3081828282 @default.
• W4320712638 cites W3085374116 @default.
• W4320712638 cites W3108924494 @default.
• W4320712638 cites W3126848236 @default.
• W4320712638 cites W3129878176 @default.
• W4320712638 cites W3134035175 @default.
• W4320712638 cites W3145969289 @default.
• W4320712638 cites W3173303428 @default.
• W4320712638 cites W4220735638 @default.
• W4320712638 cites W4226086751 @default.
• W4320712638 doi "https://doi.org/10.3389/fimmu.2023.1099356" @default.
• W4320712638 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36865544" @default.
• W4320712638 hasPublicationYear "2023" @default.
• W4320712638 type Work @default.
• W4320712638 citedByCount "1" @default.
• W4320712638 countsByYear W43207126382023 @default.
• W4320712638 crossrefType "journal-article" @default.

• next