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- W4320712874 abstract "Genome-wide association studies (GWAS) have identified hundreds of genetic risk loci for coronary artery disease (CAD). However, non-European populations are underrepresented in GWAS and the causal gene-regulatory mechanisms of these risk loci during atherosclerosis remain unclear. We incorporated local ancestry and haplotype information to identify quantitative trait loci (QTL) for gene expression and splicing in coronary arteries obtained from 138 ancestrally diverse Americans. Of 2,132 eQTL-associated genes (eGenes), 47% were previously unreported in coronary arteries and 19% exhibited cell-type-specific expression. Colocalization analysis with GWAS identified subgroups of eGenes unique to CAD and blood pressure. Fine-mapping highlighted additional eGenes of interest, including TBX20 and IL5 . Splicing (s)QTLs for 1,690 genes were also identified, among which TOR1AIP1 and ULK3 sQTLs demonstrated the importance of evaluating splicing events to accurately identify disease-relevant gene expression. Our work provides the first human coronary artery eQTL resource from a patient sample and exemplifies the necessity of diverse study populations and multi-omic approaches to characterize gene regulation in critical disease processes." @default.
- W4320712874 created "2023-02-15" @default.
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- W4320712874 date "2023-02-14" @default.
- W4320712874 modified "2023-10-02" @default.
- W4320712874 title "Integrative multi-ancestry genetic analysis of gene regulation in coronary arteries prioritizes disease risk loci" @default.
- W4320712874 cites W1119021472 @default.
- W4320712874 cites W1169308033 @default.
- W4320712874 cites W1533942137 @default.
- W4320712874 cites W1964655626 @default.
- W4320712874 cites W1967958015 @default.
- W4320712874 cites W1971378307 @default.
- W4320712874 cites W1978546929 @default.
- W4320712874 cites W1980887908 @default.
- W4320712874 cites W1984068087 @default.
- W4320712874 cites W1986911601 @default.
- W4320712874 cites W1992664147 @default.
- W4320712874 cites W1999574084 @default.
- W4320712874 cites W2001629081 @default.
- W4320712874 cites W2018766190 @default.
- W4320712874 cites W2025943989 @default.
- W4320712874 cites W2038667626 @default.
- W4320712874 cites W2057216196 @default.
- W4320712874 cites W2072657325 @default.
- W4320712874 cites W2088338354 @default.
- W4320712874 cites W2099085143 @default.
- W4320712874 cites W2099328768 @default.
- W4320712874 cites W2102619694 @default.
- W4320712874 cites W2104549677 @default.
- W4320712874 cites W2106578986 @default.
- W4320712874 cites W2108234281 @default.
- W4320712874 cites W2112578120 @default.
- W4320712874 cites W2112848098 @default.
- W4320712874 cites W2124655419 @default.
- W4320712874 cites W2128371599 @default.
- W4320712874 cites W2137747126 @default.
- W4320712874 cites W2141284336 @default.
- W4320712874 cites W2143837955 @default.
- W4320712874 cites W2144504271 @default.
- W4320712874 cites W2149935397 @default.
- W4320712874 cites W2149992227 @default.
- W4320712874 cites W2169456326 @default.
- W4320712874 cites W2196135315 @default.
- W4320712874 cites W2221356560 @default.
- W4320712874 cites W2238851414 @default.
- W4320712874 cites W2259938310 @default.
- W4320712874 cites W2328393125 @default.
- W4320712874 cites W2344561059 @default.
- W4320712874 cites W2404651638 @default.
- W4320712874 cites W2467359821 @default.
- W4320712874 cites W2516224023 @default.
- W4320712874 cites W2522116600 @default.
- W4320712874 cites W2556167715 @default.
- W4320712874 cites W2560104334 @default.
- W4320712874 cites W2581719226 @default.
- W4320712874 cites W2587804655 @default.
- W4320712874 cites W2597132418 @default.
- W4320712874 cites W2598022332 @default.
- W4320712874 cites W2598938834 @default.
- W4320712874 cites W2735404270 @default.
- W4320712874 cites W2751774580 @default.
- W4320712874 cites W2761275051 @default.
- W4320712874 cites W2765408510 @default.
- W4320712874 cites W2774883395 @default.
- W4320712874 cites W2775393828 @default.
- W4320712874 cites W2777667999 @default.
- W4320712874 cites W2794111130 @default.
- W4320712874 cites W2883415719 @default.
- W4320712874 cites W2892248572 @default.
- W4320712874 cites W2894831642 @default.
- W4320712874 cites W2898598946 @default.
- W4320712874 cites W2903416893 @default.
- W4320712874 cites W2909194804 @default.
- W4320712874 cites W2918020747 @default.
- W4320712874 cites W2922687374 @default.
- W4320712874 cites W2935688323 @default.
- W4320712874 cites W2943532730 @default.
- W4320712874 cites W2944545583 @default.
- W4320712874 cites W2945784897 @default.
- W4320712874 cites W2950044823 @default.
- W4320712874 cites W2951755171 @default.