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- W4320716800 abstract "The excitatory amino acid transporter 2 (EAAT2) plays a key role in the clearance and recycling of glutamate - the major excitatory neurotransmitter in the mammalian brain. EAAT2 loss/dysfunction triggers a cascade of neurodegenerative events, comprising glutamatergic excitotoxicity and neuronal death. Nevertheless, our current knowledge regarding EAAT2 in neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS) and Alzheimer’s disease (AD), is restricted to post-mortem analysis of brain tissue and experimental models. Thus, detecting EAAT2 in the living human brain might be crucial to improve diagnosis/therapy for ALS and AD. This perspective article describes the role of EAAT2 in physio/pathological processes and provides a structure–activity relationship of EAAT2-binders, bringing two perspectives: therapy (activators) and diagnosis (molecular imaging tools)." @default.
- W4320716800 created "2023-02-15" @default.
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- W4320716800 creator A5074513956 @default.
- W4320716800 date "2023-02-14" @default.
- W4320716800 modified "2023-10-14" @default.
- W4320716800 title "A Medicinal Chemistry Perspective on Excitatory Amino Acid Transporter 2 Dysfunction in Neurodegenerative Diseases" @default.
- W4320716800 cites W1556418042 @default.
- W4320716800 cites W1568637440 @default.
- W4320716800 cites W1589269270 @default.
- W4320716800 cites W1601632182 @default.
- W4320716800 cites W1644388421 @default.
- W4320716800 cites W1686065874 @default.
- W4320716800 cites W1747781838 @default.
- W4320716800 cites W1766931972 @default.
- W4320716800 cites W1849350460 @default.
- W4320716800 cites W1900227502 @default.
- W4320716800 cites W1913069989 @default.
- W4320716800 cites W1953585322 @default.
- W4320716800 cites W1966698297 @default.
- W4320716800 cites W1969400861 @default.
- W4320716800 cites W1970642506 @default.
- W4320716800 cites W1971639674 @default.
- W4320716800 cites W1972737184 @default.
- W4320716800 cites W1972906411 @default.
- W4320716800 cites W1973765221 @default.
- W4320716800 cites W1976387924 @default.
- W4320716800 cites W1977470009 @default.
- W4320716800 cites W1978361606 @default.
- W4320716800 cites W1978632856 @default.
- W4320716800 cites W1979589320 @default.
- W4320716800 cites W1981765517 @default.
- W4320716800 cites W1983197885 @default.
- W4320716800 cites W1988278010 @default.
- W4320716800 cites W1992193294 @default.
- W4320716800 cites W1995963726 @default.
- W4320716800 cites W2000208781 @default.
- W4320716800 cites W2001618696 @default.
- W4320716800 cites W2001845218 @default.
- W4320716800 cites W2003982930 @default.
- W4320716800 cites W2005883079 @default.
- W4320716800 cites W2007872436 @default.
- W4320716800 cites W2011313733 @default.
- W4320716800 cites W2012850137 @default.
- W4320716800 cites W2014568461 @default.
- W4320716800 cites W2014963273 @default.
- W4320716800 cites W2016575029 @default.
- W4320716800 cites W2024285818 @default.
- W4320716800 cites W2027308821 @default.
- W4320716800 cites W2028138492 @default.
- W4320716800 cites W2029624481 @default.
- W4320716800 cites W2032627181 @default.
- W4320716800 cites W2032653084 @default.
- W4320716800 cites W2032925300 @default.
- W4320716800 cites W2033476668 @default.
- W4320716800 cites W2034182513 @default.
- W4320716800 cites W2037230855 @default.
- W4320716800 cites W2037414045 @default.
- W4320716800 cites W2039605179 @default.
- W4320716800 cites W2042892935 @default.
- W4320716800 cites W2048496572 @default.
- W4320716800 cites W2049611687 @default.
- W4320716800 cites W2050523782 @default.
- W4320716800 cites W2050890908 @default.
- W4320716800 cites W2052780535 @default.
- W4320716800 cites W2054683291 @default.
- W4320716800 cites W2057571594 @default.
- W4320716800 cites W2058569458 @default.
- W4320716800 cites W2058948754 @default.
- W4320716800 cites W2060349738 @default.
- W4320716800 cites W2061661044 @default.
- W4320716800 cites W2062657498 @default.
- W4320716800 cites W2065116247 @default.
- W4320716800 cites W2066955068 @default.
- W4320716800 cites W2067701751 @default.
- W4320716800 cites W2072623748 @default.
- W4320716800 cites W2073016063 @default.
- W4320716800 cites W2077910869 @default.
- W4320716800 cites W2079185455 @default.
- W4320716800 cites W2084250676 @default.
- W4320716800 cites W2084250976 @default.
- W4320716800 cites W2086896764 @default.
- W4320716800 cites W2088918402 @default.
- W4320716800 cites W2092358916 @default.
- W4320716800 cites W2093248607 @default.
- W4320716800 cites W2094673798 @default.
- W4320716800 cites W2094805317 @default.
- W4320716800 cites W2095267065 @default.
- W4320716800 cites W2096963202 @default.
- W4320716800 cites W2098072359 @default.
- W4320716800 cites W2099687721 @default.
- W4320716800 cites W2101500902 @default.
- W4320716800 cites W2103703613 @default.
- W4320716800 cites W2106139304 @default.