FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4320717002> ?p ?o ?g. }

• W4320717002 abstract "Abstract Background: Histone deacetylase (HDAC) families regulate a wide range of physical processes and development of several diseases, and the role of HDACs in asthma development and progression is worth further investigation. This study aimed to evaluate HDAC effects in a mouse model of asthma. Methods: HDAC8 selective inhibitor PCI-34051 was administered to a mouse model of ovalbumin (OVA)-sensitized and challenged asthma. Airway responsiveness, serum cytokines, histological changes of the airway, and expression levels of α-SMA, b-actin, VEGFR, VEGF, GAPDH, HDAC8, TGF-b3, CD 105, p-ERK 1/2, ERK 1/2, PI3K, p-AKT, AKT, and PDK1 were evaluated. The miR-381-3p level was also measured. Results: All classic histologic and cellular changes of asthma in inflammation and airway remodeling were altered by HDAC8 inhibitor PCI-34051 via regulating the miR-381-3p level and its downstream gene TGF-b3. Inhibition of TGF-b3 further reduced the activation of ERK, PI3K, AKT and PDK1. Conclusions: HDAC8 inhibitor PCI-34051 exhibits comprehensive control of asthmatic changes, including inflammation and airway remodeling, in a mouse model." @default.
• W4320717002 created "2023-02-15" @default.
• W4320717002 creator A5032360806 @default.
• W4320717002 creator A5035786375 @default.
• W4320717002 creator A5039217315 @default.
• W4320717002 creator A5042823599 @default.
• W4320717002 creator A5060034313 @default.
• W4320717002 creator A5061232040 @default.
• W4320717002 creator A5070036406 @default.
• W4320717002 date "2023-02-14" @default.
• W4320717002 modified "2023-09-26" @default.
• W4320717002 title "HDAC8-Selective Inhibition by PCI-34051 Attenuates Inflammation and Airway Remodeling in Asthma via miR-381-3p-TGFβ3 axis" @default.
• W4320717002 cites W1499417605 @default.
• W4320717002 cites W1509033214 @default.
• W4320717002 cites W1532707293 @default.
• W4320717002 cites W1843986322 @default.
• W4320717002 cites W1978924411 @default.
• W4320717002 cites W2015284016 @default.
• W4320717002 cites W2018538436 @default.
• W4320717002 cites W2040695610 @default.
• W4320717002 cites W2051765368 @default.
• W4320717002 cites W2051806959 @default.
• W4320717002 cites W2058195928 @default.
• W4320717002 cites W2093901938 @default.
• W4320717002 cites W2107733280 @default.
• W4320717002 cites W2110937334 @default.
• W4320717002 cites W2118140057 @default.
• W4320717002 cites W2118295402 @default.
• W4320717002 cites W2131437805 @default.
• W4320717002 cites W2153231621 @default.
• W4320717002 cites W2153642908 @default.
• W4320717002 cites W2162674813 @default.
• W4320717002 cites W2165484058 @default.
• W4320717002 cites W2168855289 @default.
• W4320717002 cites W2258249404 @default.
• W4320717002 cites W2514363696 @default.
• W4320717002 cites W2807280095 @default.
• W4320717002 cites W2883085934 @default.
• W4320717002 cites W2885854339 @default.
• W4320717002 cites W3012367931 @default.
• W4320717002 cites W3207987303 @default.
• W4320717002 doi "https://doi.org/10.21203/rs.3.rs-2573090/v1" @default.
• W4320717002 hasPublicationYear "2023" @default.
• W4320717002 type Work @default.
• W4320717002 citedByCount "0" @default.
• W4320717002 crossrefType "posted-content" @default.
• W4320717002 hasAuthorship W4320717002A5032360806 @default.
• W4320717002 hasAuthorship W4320717002A5035786375 @default.
• W4320717002 hasAuthorship W4320717002A5039217315 @default.
• W4320717002 hasAuthorship W4320717002A5042823599 @default.
• W4320717002 hasAuthorship W4320717002A5060034313 @default.
• W4320717002 hasAuthorship W4320717002A5061232040 @default.
• W4320717002 hasAuthorship W4320717002A5070036406 @default.
• W4320717002 hasBestOaLocation W43207170021 @default.
• W4320717002 hasConcept C104317684 @default.
• W4320717002 hasConcept C105922876 @default.
• W4320717002 hasConcept C184235292 @default.
• W4320717002 hasConcept C185592680 @default.
• W4320717002 hasConcept C203014093 @default.
• W4320717002 hasConcept C25737173 @default.
• W4320717002 hasConcept C2776042228 @default.
• W4320717002 hasConcept C2776914184 @default.
• W4320717002 hasConcept C2776946954 @default.
• W4320717002 hasConcept C2778305200 @default.
• W4320717002 hasConcept C42219234 @default.
• W4320717002 hasConcept C502942594 @default.
• W4320717002 hasConcept C55493867 @default.
• W4320717002 hasConcept C57074206 @default.
• W4320717002 hasConcept C62478195 @default.
• W4320717002 hasConcept C64927066 @default.
• W4320717002 hasConcept C71924100 @default.
• W4320717002 hasConcept C75217442 @default.
• W4320717002 hasConcept C86554907 @default.
• W4320717002 hasConcept C86803240 @default.
• W4320717002 hasConcept C8891405 @default.
• W4320717002 hasConcept C95444343 @default.
• W4320717002 hasConceptScore W4320717002C104317684 @default.
• W4320717002 hasConceptScore W4320717002C105922876 @default.
• W4320717002 hasConceptScore W4320717002C184235292 @default.
• W4320717002 hasConceptScore W4320717002C185592680 @default.
• W4320717002 hasConceptScore W4320717002C203014093 @default.
• W4320717002 hasConceptScore W4320717002C25737173 @default.
• W4320717002 hasConceptScore W4320717002C2776042228 @default.
• W4320717002 hasConceptScore W4320717002C2776914184 @default.
• W4320717002 hasConceptScore W4320717002C2776946954 @default.
• W4320717002 hasConceptScore W4320717002C2778305200 @default.
• W4320717002 hasConceptScore W4320717002C42219234 @default.
• W4320717002 hasConceptScore W4320717002C502942594 @default.
• W4320717002 hasConceptScore W4320717002C55493867 @default.
• W4320717002 hasConceptScore W4320717002C57074206 @default.
• W4320717002 hasConceptScore W4320717002C62478195 @default.
• W4320717002 hasConceptScore W4320717002C64927066 @default.
• W4320717002 hasConceptScore W4320717002C71924100 @default.
• W4320717002 hasConceptScore W4320717002C75217442 @default.
• W4320717002 hasConceptScore W4320717002C86554907 @default.
• W4320717002 hasConceptScore W4320717002C86803240 @default.
• W4320717002 hasConceptScore W4320717002C8891405 @default.
• W4320717002 hasConceptScore W4320717002C95444343 @default.
• W4320717002 hasLocation W43207170021 @default.
• W4320717002 hasOpenAccess W4320717002 @default.

• next