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• W4320717373 abstract "<b><i>Background:</i></b> This study aimed to describe disease activity, clinical outcome, and overall patterns of lupus nephritis care in patients who received belimumab in a real-world clinical setting in China. <b><i>Materials and Methods:</i></b> This observational cohort study included lupus nephritis patients who received belimumab as adjunct therapy. We deeply investigated the characteristics of those patients including clinical response to belimumab and safety. <b><i>Results:</i></b> All 61 lupus nephritis patients were included with a median follow-up period of 9 months (6, 19). Prevalence of proteinuria (52.5–24.6%) and hematuria (33.3–9.8%) was decreased with a stable level of eGFR at last visit. The percentage of patients achieved complete or partial renal response increased from 47.5% to 78.7% and the proportion of complete or partial renal response in patients with proliferative lupus nephritis was higher than those with membranous lupus nephritis (75 vs. 50%) at last visit. The median SLEDAI score decreased from 6 to 2, and there was an increase in patient of LLDAS from 17 to 33 at last visit. A notable dose reduction was seen for glucocorticosteroid dose, with a median change from 10 to 5 mg/d. The proportion of patients receiving &gt;7.5 mg/d steroids reduced from 52.5% at baseline to 23.0% at last visit. The discontinuation of belimumab was rare (3/61) for drug-induced fever, hyperthyroidism, and uveitis. <b><i>Conclusions:</i></b> Lupus nephritis patients with belimumab demonstrated improvements in clinical response and a reduction in glucocorticosteroids, which provided evidence of effectiveness and safety in real-world clinical practice in China." @default.
• W4320717373 created "2023-02-15" @default.
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• W4320717373 date "2023-01-01" @default.
• W4320717373 modified "2023-10-05" @default.
• W4320717373 title "Efficacy and safety of belimumab in lupus nephritis patients: a real-world observational study in China" @default.
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• W4320717373 doi "https://doi.org/10.1159/000529675" @default.
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