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- W4320717508 endingPage "135685" @default.
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- W4320717508 abstract "Sodium alginate (SA) was used to coat liposomes containing DPP-IV inhibitory collagen peptides to improve their stability and in vitro absorption for intra-oral delivery. The liposome structure as well as entrapment efficiency and DPP-IV inhibitory activity was characterized. The liposome stability was determined by measuring in vitro release rates and their gastrointestinal stability. Transcellular permeability of liposomes was further tested to characterize their permeability in small intestinal epithelial cells. The results showed that the 0.3% SA coating increased the diameter (166.7 nm to 249.9 nm), absolute value of zeta potential (30.2 mV to 40.1 mV) and entrapment efficiency (61.52% to 70.99%) of liposomes. The SA-coated liposomes containing collagen peptides showed enhanced storage stability within one month, gastrointestinal stability increased by 50% in bioavailability, transcellular permeability increased by 18% in transmission percentage, and in vitro release rates reduced by 34%, compared to uncoated liposomes. SA coating liposomes are promising carriers for transporting hydrophilic molecules, may be beneficial for improving nutrient absorption and can protect bioactive compounds from being inactivated in the gastrointestinal tract." @default.
- W4320717508 created "2023-02-15" @default.
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- W4320717508 date "2023-07-01" @default.
- W4320717508 modified "2023-10-10" @default.
- W4320717508 title "Use of sodium alginate coatings to improve bioavailability of liposomes containing DPP-IV inhibitory collagen peptides" @default.
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- W4320717508 doi "https://doi.org/10.1016/j.foodchem.2023.135685" @default.
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