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- W4320717744 endingPage "71" @default.
- W4320717744 startingPage "57" @default.
- W4320717744 abstract "Parkinson's disease is a progressive neurodegenerative disorder that is associated with motor and nonmotor symptoms. Accumulation of misfolded α-synuclein is considered a key pathological feature during disease initiation and progression. While clearly deemed a synucleinopathy, the development of amyloid-β plaques, tau-containing neurofibrillary tangles, and even TDP-43 protein inclusions occur within the nigrostriatal system and in other brain regions. In addition, inflammatory responses, manifested by glial reactivity, T-cell infiltration, and increased expression of inflammatory cytokines, plus other toxic mediators derived from activated glial cells, are currently recognized as prominent drivers of Parkinson's disease pathology. However, copathologies have increasingly been recognized as the rule (> 90%) and not the exception, with Parkinson's disease cases on average exhibiting three different copathologies. While microinfarcts, atherosclerosis, arteriolosclerosis, and cerebral amyloid angiopathy may have an impact on disease progression, α-synuclein, amyloid-β, and TDP-43 pathology do not seem to contribute to progression." @default.
- W4320717744 created "2023-02-15" @default.
- W4320717744 creator A5037517823 @default.
- W4320717744 creator A5074765508 @default.
- W4320717744 creator A5077753619 @default.
- W4320717744 date "2023-01-01" @default.
- W4320717744 modified "2023-10-04" @default.
- W4320717744 title "Mixed pathology as a rule, not exception: Time to reconsider disease nosology" @default.
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