FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4320718571> ?p ?o ?g. }

• W4320718571 endingPage "813" @default.
• W4320718571 startingPage "803" @default.
• W4320718571 abstract "INTRODUCTION Severe traumatic injury with shock can lead to direct and indirect organ injury; however, tissue-specific biomarkers are limited in clinical panels. We used proteomic and metabolomic databases to identify organ injury patterns after severe injury in humans. METHODS Plasma samples (times 0, 24, and 72 hours after arrival to trauma center) from injured patients enrolled in two randomized prehospital trials were subjected to multiplexed proteomics (SomaLogic Inc., Boulder, CO). Patients were categorized by outcome: nonresolvers (died >72 hours or required ≥7 days of critical care), resolvers (survived to 30 days and required <7 days of critical care), and low Injury Severity Score (ISS) controls. Established tissue-specific biomarkers were identified through a literature review and cross-referenced with tissue specificity from the Human Protein Atlas. Untargeted plasma metabolomics (Metabolon Inc., Durham, NC), inflammatory mediators, and endothelial damage markers were correlated with injury biomarkers. Kruskal-Wallis/Mann-Whitney U tests with false discovery rate correction assessed differences in biomarker expression across outcome groups (significance; p < 0.1). RESULTS Of 142 patients, 78 were nonresolvers (median ISS, 30), 34 were resolvers (median ISS, 22), and 30 were low ISS controls (median ISS, 1). A broad release of tissue-specific damage markers was observed at admission; this was greater in nonresolvers. By 72 hours, nine cardiac, three liver, eight neurologic, and three pulmonary proteins remained significantly elevated in nonresolvers compared with resolvers. Cardiac damage biomarkers showed the greatest elevations at 72 hours in nonresolvers and had significant positive correlations with proinflammatory mediators and endothelial damage markers. Nonresolvers had lower concentrations of fatty acid metabolites compared with resolvers, particularly acyl carnitines and cholines. CONCLUSION We identified an immediate release of tissue-specific biomarkers with sustained elevation in the liver, pulmonary, neurologic, and especially cardiac injury biomarkers in patients with complex clinical courses after severe injury. The persistent myocardial injury in nonresolvers may be due to a combination of factors including metabolic stress, inflammation, and endotheliopathy." @default.
• W4320718571 created "2023-02-15" @default.
• W4320718571 creator A5005830174 @default.
• W4320718571 creator A5006471489 @default.
• W4320718571 creator A5019152371 @default.
• W4320718571 creator A5019370603 @default.
• W4320718571 creator A5023924586 @default.
• W4320718571 creator A5024824274 @default.
• W4320718571 creator A5029058133 @default.
• W4320718571 creator A5029701587 @default.
• W4320718571 creator A5029774861 @default.
• W4320718571 creator A5038737181 @default.
• W4320718571 creator A5040176601 @default.
• W4320718571 creator A5042608995 @default.
• W4320718571 creator A5053256146 @default.
• W4320718571 creator A5060980576 @default.
• W4320718571 creator A5062076820 @default.
• W4320718571 creator A5063082654 @default.
• W4320718571 creator A5065252445 @default.
• W4320718571 creator A5082324385 @default.
• W4320718571 date "2023-02-13" @default.
• W4320718571 modified "2023-10-17" @default.
• W4320718571 title "High-dimensional proteomics identifies organ injury patterns associated with outcomes in human trauma" @default.
• W4320718571 cites W1968550558 @default.
• W4320718571 cites W1994059359 @default.
• W4320718571 cites W2005450615 @default.
• W4320718571 cites W2008126933 @default.
• W4320718571 cites W2021572350 @default.
• W4320718571 cites W2023060522 @default.
• W4320718571 cites W2026842867 @default.
• W4320718571 cites W2030449930 @default.
• W4320718571 cites W2043353429 @default.
• W4320718571 cites W2071996924 @default.
• W4320718571 cites W2081031767 @default.
• W4320718571 cites W2084373725 @default.
• W4320718571 cites W2093358798 @default.
• W4320718571 cites W2112125919 @default.
• W4320718571 cites W2134754219 @default.
• W4320718571 cites W2136094484 @default.
• W4320718571 cites W2149647442 @default.
• W4320718571 cites W2157785265 @default.
• W4320718571 cites W2290337523 @default.
• W4320718571 cites W2345769169 @default.
• W4320718571 cites W2586773298 @default.
• W4320718571 cites W2607011771 @default.
• W4320718571 cites W2735497854 @default.
• W4320718571 cites W2757167310 @default.
• W4320718571 cites W2883181532 @default.
• W4320718571 cites W2900685268 @default.
• W4320718571 cites W2962767741 @default.
• W4320718571 cites W3005713561 @default.
• W4320718571 cites W3008003211 @default.
• W4320718571 cites W3013413227 @default.
• W4320718571 cites W3036926163 @default.
• W4320718571 cites W3092693700 @default.
• W4320718571 cites W3118836301 @default.
• W4320718571 cites W4205219984 @default.
• W4320718571 cites W4292860540 @default.
• W4320718571 cites W826966419 @default.
• W4320718571 doi "https://doi.org/10.1097/ta.0000000000003880" @default.
• W4320718571 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36787435" @default.
• W4320718571 hasPublicationYear "2023" @default.
• W4320718571 type Work @default.
• W4320718571 citedByCount "1" @default.
• W4320718571 crossrefType "journal-article" @default.
• W4320718571 hasAuthorship W4320718571A5005830174 @default.
• W4320718571 hasAuthorship W4320718571A5006471489 @default.
• W4320718571 hasAuthorship W4320718571A5019152371 @default.
• W4320718571 hasAuthorship W4320718571A5019370603 @default.
• W4320718571 hasAuthorship W4320718571A5023924586 @default.
• W4320718571 hasAuthorship W4320718571A5024824274 @default.
• W4320718571 hasAuthorship W4320718571A5029058133 @default.
• W4320718571 hasAuthorship W4320718571A5029701587 @default.
• W4320718571 hasAuthorship W4320718571A5029774861 @default.
• W4320718571 hasAuthorship W4320718571A5038737181 @default.
• W4320718571 hasAuthorship W4320718571A5040176601 @default.
• W4320718571 hasAuthorship W4320718571A5042608995 @default.
• W4320718571 hasAuthorship W4320718571A5053256146 @default.
• W4320718571 hasAuthorship W4320718571A5060980576 @default.
• W4320718571 hasAuthorship W4320718571A5062076820 @default.
• W4320718571 hasAuthorship W4320718571A5063082654 @default.
• W4320718571 hasAuthorship W4320718571A5065252445 @default.
• W4320718571 hasAuthorship W4320718571A5082324385 @default.
• W4320718571 hasBestOaLocation W43207185712 @default.
• W4320718571 hasConcept C104317684 @default.
• W4320718571 hasConcept C124535831 @default.
• W4320718571 hasConcept C126322002 @default.
• W4320718571 hasConcept C164027704 @default.
• W4320718571 hasConcept C190385971 @default.
• W4320718571 hasConcept C194828623 @default.
• W4320718571 hasConcept C2776914184 @default.
• W4320718571 hasConcept C2781197716 @default.
• W4320718571 hasConcept C3017944768 @default.
• W4320718571 hasConcept C46111723 @default.
• W4320718571 hasConcept C535046627 @default.
• W4320718571 hasConcept C55493867 @default.
• W4320718571 hasConcept C60644358 @default.
• W4320718571 hasConcept C63363279 @default.

• next