Matches in SemOpenAlex for { <https://semopenalex.org/work/W4320718974> ?p ?o ?g. }
- W4320718974 abstract "Abstract The functional domain of the cerebellum has expanded beyond motor control to also include cognitive and affective functions. In line with this notion, cerebellar volume has increased over recent primate evolution, and cerebellar alterations have been linked to heritable mental disorders. To map the genetic architecture of human cerebellar morphology, we here studied a large imaging genetics sample from the UK Biobank (n discovery = 27,302; n replication: 11,264) with state-of-the art neuroimaging and biostatistics tools. Multivariate GWAS (MOSTest) on empirically derived regional cerebellar MRI features yielded 351 significant genetic loci (228 novel, 94% replicated). Candidate SNPs showed significant positive enrichment for relatively recent genetic mutations over the last 300k years (i.e., coinciding with the emergence of Homo sapiens), while gene level analyses revealed enrichment for genes associated with human-specific evolution over the last ∼6-8 million years. Finally, we observed genetic overlap with major mental disorders, reinforcing the notion of cerebellar involvement in psychopathology. Teaser Genome-wide analysis of cerebellar morphology reveals links to recent human evolution and psychopathology" @default.
- W4320718974 created "2023-02-15" @default.
- W4320718974 creator A5002668347 @default.
- W4320718974 creator A5004304018 @default.
- W4320718974 creator A5005956415 @default.
- W4320718974 creator A5017065424 @default.
- W4320718974 creator A5022164078 @default.
- W4320718974 creator A5042733882 @default.
- W4320718974 creator A5044423729 @default.
- W4320718974 creator A5058326746 @default.
- W4320718974 creator A5059061206 @default.
- W4320718974 creator A5064324947 @default.
- W4320718974 creator A5068749110 @default.
- W4320718974 creator A5074508432 @default.
- W4320718974 creator A5080420774 @default.
- W4320718974 creator A5084649001 @default.
- W4320718974 creator A5089623913 @default.
- W4320718974 date "2023-02-14" @default.
- W4320718974 modified "2023-10-18" @default.
- W4320718974 title "The genetic architecture of human cerebellar morphology supports a key role for the cerebellum in recent human evolution and psychopathology" @default.
- W4320718974 cites W1964113540 @default.
- W4320718974 cites W1975341011 @default.
- W4320718974 cites W1981786093 @default.
- W4320718974 cites W1982636457 @default.
- W4320718974 cites W1984068087 @default.
- W4320718974 cites W1984714101 @default.
- W4320718974 cites W1996885705 @default.
- W4320718974 cites W2000990523 @default.
- W4320718974 cites W2004293194 @default.
- W4320718974 cites W2009927339 @default.
- W4320718974 cites W2014270327 @default.
- W4320718974 cites W2033151532 @default.
- W4320718974 cites W2040975718 @default.
- W4320718974 cites W2048335199 @default.
- W4320718974 cites W2051314902 @default.
- W4320718974 cites W2055655674 @default.
- W4320718974 cites W2060138087 @default.
- W4320718974 cites W2061043823 @default.
- W4320718974 cites W2063243332 @default.
- W4320718974 cites W2065397672 @default.
- W4320718974 cites W2067456724 @default.
- W4320718974 cites W2072408668 @default.
- W4320718974 cites W2104549677 @default.
- W4320718974 cites W2122926243 @default.
- W4320718974 cites W2130410032 @default.
- W4320718974 cites W2131233061 @default.
- W4320718974 cites W2133111499 @default.
- W4320718974 cites W2134820284 @default.
- W4320718974 cites W2141820415 @default.
- W4320718974 cites W2153254791 @default.
- W4320718974 cites W2153860431 @default.
- W4320718974 cites W2160995259 @default.
- W4320718974 cites W2170172094 @default.
- W4320718974 cites W2171037992 @default.
- W4320718974 cites W2188343695 @default.
- W4320718974 cites W2214074259 @default.
- W4320718974 cites W2222512263 @default.
- W4320718974 cites W2260830658 @default.
- W4320718974 cites W2308915325 @default.
- W4320718974 cites W2328393125 @default.
- W4320718974 cites W2347068649 @default.
- W4320718974 cites W2462053388 @default.
- W4320718974 cites W2511414678 @default.
- W4320718974 cites W2518640130 @default.
- W4320718974 cites W2522953732 @default.
- W4320718974 cites W2522993044 @default.
- W4320718974 cites W2528236220 @default.
- W4320718974 cites W2530951644 @default.
- W4320718974 cites W2594949498 @default.
- W4320718974 cites W2595560054 @default.
- W4320718974 cites W2614464346 @default.
- W4320718974 cites W2622484995 @default.
- W4320718974 cites W2623319323 @default.
- W4320718974 cites W2728360006 @default.
- W4320718974 cites W2736045761 @default.
- W4320718974 cites W2738082385 @default.
- W4320718974 cites W2770092353 @default.
- W4320718974 cites W2773525895 @default.
- W4320718974 cites W2777388159 @default.
- W4320718974 cites W2783148479 @default.
- W4320718974 cites W2796598047 @default.
- W4320718974 cites W2796838444 @default.
- W4320718974 cites W2799642317 @default.
- W4320718974 cites W2802815532 @default.
- W4320718974 cites W2805952410 @default.
- W4320718974 cites W2895486342 @default.
- W4320718974 cites W2896481393 @default.
- W4320718974 cites W2914482125 @default.
- W4320718974 cites W2941647813 @default.
- W4320718974 cites W2948120322 @default.
- W4320718974 cites W2949466265 @default.
- W4320718974 cites W2952215064 @default.
- W4320718974 cites W2955632554 @default.
- W4320718974 cites W2967464490 @default.
- W4320718974 cites W2972435723 @default.
- W4320718974 cites W2972730029 @default.
- W4320718974 cites W2981674673 @default.
- W4320718974 cites W2986919234 @default.
- W4320718974 cites W2993382330 @default.
- W4320718974 cites W2999916586 @default.