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- W4320729282 abstract "Abstract Free carbene readily causes multiple side reactions due to its high energy, thus its asymmetric transformation is very difficult. We present here our findings of high‐p K a Brønsted acid catalysts that enable free carbene insertion into N−H bonds of amines to prepare chiral α‐amino acid derivatives with high enantioselectivity. Under irradiation with visible light, diazo compounds produce high‐energy free carbenes that are captured by amines to form free ylide intermediates, and then the newly designed high‐p K a Brønsted acids, chiral spiro phosphamides, promote the proton transfer of ylides to afford the products. Computational and kinetic studies uncover the principle for the rational design of proton‐transfer catalysts and explain how the catalysts accelerate this transformation and provide stereocontrol." @default.
- W4320729282 created "2023-02-15" @default.
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- W4320729282 date "2023-03-02" @default.
- W4320729282 modified "2023-10-14" @default.
- W4320729282 title "A Spiro Phosphamide Catalyzed Enantioselective Proton Transfer of Ylides in a Free Carbene Insertion into N−H Bonds" @default.
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- W4320729282 doi "https://doi.org/10.1002/ange.202300691" @default.
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