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- W4320730237 endingPage "3793" @default.
- W4320730237 startingPage "3793" @default.
- W4320730237 abstract "Kaposi sarcoma (KS) is an angioproliferative lesion in which two main KS cell sources are currently sustained: endothelial cells (ECs) and mesenchymal/stromal cells. Our objective is to establish the tissue location, characteristics and transdifferentiation steps to the KS cells of the latter. For this purpose, we studied specimens of 49 cases of cutaneous KS using immunochemistry and confocal and electron microscopy. The results showed that delimiting CD34+ stromal cells/Telocytes (CD34+SCs/TCs) in the external layer of the pre-existing blood vessels and around skin appendages form small convergent lumens, express markers for ECs of blood and lymphatic vessels, share ultrastructural characteristics with ECs and participate in the origin of two main types of neovessels, the evolution of which gives rise to lymphangiomatous or spindle-cell patterns-the substrate of the main KS histopathological variants. Intraluminal folds and pillars (papillae) are formed in the neovessels, which suggests they increase by vessel splitting (intussusceptive angiogenesis and intussusceptive lymphangiogenesis). In conclusion, delimiting CD34+SCs/TCs are mesenchymal/stromal cells that can transdifferentiate into KS ECs, participating in the formation of two types of neovessels. The subsequent growth of the latter involves intussusceptive mechanisms, originating several KS variants. These findings are of histogenic, clinical and therapeutic interest." @default.
- W4320730237 created "2023-02-15" @default.
- W4320730237 creator A5028901449 @default.
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- W4320730237 creator A5059014584 @default.
- W4320730237 creator A5081221509 @default.
- W4320730237 date "2023-02-14" @default.
- W4320730237 modified "2023-10-18" @default.
- W4320730237 title "Delimiting CD34+ Stromal Cells/Telocytes Are Resident Mesenchymal Cells That Participate in Neovessel Formation in Skin Kaposi Sarcoma" @default.
- W4320730237 cites W134867131 @default.
- W4320730237 cites W1523189699 @default.
- W4320730237 cites W1552031407 @default.
- W4320730237 cites W160739290 @default.
- W4320730237 cites W1966671908 @default.
- W4320730237 cites W1967029176 @default.
- W4320730237 cites W1974320163 @default.
- W4320730237 cites W1980370271 @default.
- W4320730237 cites W1983244945 @default.
- W4320730237 cites W1992655161 @default.
- W4320730237 cites W1994848073 @default.
- W4320730237 cites W1998323294 @default.
- W4320730237 cites W1999186462 @default.
- W4320730237 cites W1999884961 @default.
- W4320730237 cites W2003025783 @default.
- W4320730237 cites W2003117397 @default.
- W4320730237 cites W2011747072 @default.
- W4320730237 cites W2014716581 @default.
- W4320730237 cites W2015877527 @default.
- W4320730237 cites W2017339596 @default.
- W4320730237 cites W2019200520 @default.
- W4320730237 cites W2019421802 @default.
- W4320730237 cites W2022460596 @default.
- W4320730237 cites W2026986576 @default.
- W4320730237 cites W2031095022 @default.
- W4320730237 cites W2032458366 @default.
- W4320730237 cites W2034895665 @default.
- W4320730237 cites W2037682629 @default.
- W4320730237 cites W2061137079 @default.
- W4320730237 cites W2079656132 @default.
- W4320730237 cites W2085145003 @default.
- W4320730237 cites W2088386446 @default.
- W4320730237 cites W2103434166 @default.
- W4320730237 cites W2128876415 @default.
- W4320730237 cites W2144907960 @default.
- W4320730237 cites W2149346514 @default.
- W4320730237 cites W2155786594 @default.
- W4320730237 cites W2156541725 @default.
- W4320730237 cites W2166406196 @default.
- W4320730237 cites W2169138298 @default.
- W4320730237 cites W2252436708 @default.
- W4320730237 cites W2255012487 @default.
- W4320730237 cites W2270171913 @default.
- W4320730237 cites W2325680067 @default.
- W4320730237 cites W2342330483 @default.
- W4320730237 cites W2416729781 @default.
- W4320730237 cites W2464091022 @default.
- W4320730237 cites W2509767013 @default.
- W4320730237 cites W2531410616 @default.
- W4320730237 cites W2539804376 @default.
- W4320730237 cites W2625371898 @default.
- W4320730237 cites W2742452287 @default.
- W4320730237 cites W2761393839 @default.
- W4320730237 cites W2765115980 @default.
- W4320730237 cites W2808817412 @default.
- W4320730237 cites W2949356323 @default.
- W4320730237 cites W2953811398 @default.
- W4320730237 cites W2962528896 @default.
- W4320730237 cites W2979148661 @default.
- W4320730237 cites W2980133460 @default.
- W4320730237 cites W2997970243 @default.
- W4320730237 cites W3004117252 @default.
- W4320730237 cites W3009377249 @default.
- W4320730237 cites W3011152066 @default.
- W4320730237 cites W3015607410 @default.
- W4320730237 cites W3036039434 @default.
- W4320730237 cites W3049571489 @default.
- W4320730237 cites W3114455112 @default.
- W4320730237 cites W3116325476 @default.
- W4320730237 cites W3159856264 @default.
- W4320730237 cites W3175378521 @default.
- W4320730237 cites W3178447239 @default.
- W4320730237 cites W3180303453 @default.
- W4320730237 cites W3197321952 @default.
- W4320730237 cites W3211626149 @default.
- W4320730237 cites W4214934241 @default.
- W4320730237 cites W4254504288 @default.
- W4320730237 cites W4280579059 @default.
- W4320730237 cites W4291465470 @default.
- W4320730237 doi "https://doi.org/10.3390/ijms24043793" @default.
- W4320730237 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36835203" @default.
- W4320730237 hasPublicationYear "2023" @default.
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