FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4320730400> ?p ?o ?g. }

• W4320730400 endingPage "1220" @default.
• W4320730400 startingPage "1210" @default.
• W4320730400 abstract "Angiotensin converting enzyme 2 (ACE2) functions as an enzyme that produces angiotensin 1-7 (A1-7) from angiotensin II (AII) in the renin-angiotensin system (RAS). We evaluated aging phenotypes, especially skeletal muscle aging, in ACE2 systemically deficient (ACE2 KO) mice and found that ACE2 has an antiaging function. The characteristic aging phenotype observed in ACE2 KO mice was not reproduced in mice deficient in the A1-7 receptor Mas or in Tsukuba hypertensive mice, a model of chronic AII overproduction, suggesting that ACE2 has a RAS-independent antiaging function. In this review, the results we have obtained and related studies on the aging regulatory mechanism mediated by RAS components will be presented and summarized. We evaluated the aging phenotype of ACE2 systemically deficient (ACE2 KO) mice, particularly skeletal muscle aging, and found that ACE2 has an antiaging function. The characteristic aging phenotype observed in ACE2 KO mice was not reproduced in Mas KO mice, angiotensin 1-7 receptor-deficient mice or in Tsukuba hypertensive mice, a model of chronic angiotensin II overproduction, suggesting that the antiaging functions of ACE2 are independent of the renin-angiotensin system (RAS)." @default.
• W4320730400 created "2023-02-15" @default.
• W4320730400 creator A5000458736 @default.
• W4320730400 creator A5011935809 @default.
• W4320730400 creator A5021267745 @default.
• W4320730400 creator A5049699552 @default.
• W4320730400 creator A5080124007 @default.
• W4320730400 date "2023-02-14" @default.
• W4320730400 modified "2023-10-09" @default.
• W4320730400 title "Is the anti-aging effect of ACE2 due to its role in the renin-angiotensin system?—Findings from a comparison of the aging phenotypes of ACE2-deficient, Tsukuba hypertensive, and Mas-deficient mice—" @default.
• W4320730400 cites W1505408758 @default.
• W4320730400 cites W1518308338 @default.
• W4320730400 cites W1594727967 @default.
• W4320730400 cites W1891894117 @default.
• W4320730400 cites W1966225243 @default.
• W4320730400 cites W1968286569 @default.
• W4320730400 cites W1970453310 @default.
• W4320730400 cites W1971400022 @default.
• W4320730400 cites W1974759520 @default.
• W4320730400 cites W1974985368 @default.
• W4320730400 cites W1982481909 @default.
• W4320730400 cites W1994917595 @default.
• W4320730400 cites W2000040025 @default.
• W4320730400 cites W2000853233 @default.
• W4320730400 cites W2004602258 @default.
• W4320730400 cites W2004840558 @default.
• W4320730400 cites W2009359363 @default.
• W4320730400 cites W2012336972 @default.
• W4320730400 cites W2014180213 @default.
• W4320730400 cites W2014447414 @default.
• W4320730400 cites W2017614891 @default.
• W4320730400 cites W2018431713 @default.
• W4320730400 cites W2021687241 @default.
• W4320730400 cites W2025072503 @default.
• W4320730400 cites W2025672718 @default.
• W4320730400 cites W2032831426 @default.
• W4320730400 cites W2038901370 @default.
• W4320730400 cites W2039177386 @default.
• W4320730400 cites W2045619262 @default.
• W4320730400 cites W2054168325 @default.
• W4320730400 cites W2055427232 @default.
• W4320730400 cites W2058242131 @default.
• W4320730400 cites W2060507572 @default.
• W4320730400 cites W2072399660 @default.
• W4320730400 cites W2075340072 @default.
• W4320730400 cites W2078757411 @default.
• W4320730400 cites W2086389958 @default.
• W4320730400 cites W2088074787 @default.
• W4320730400 cites W2089394474 @default.
• W4320730400 cites W2093730768 @default.
• W4320730400 cites W2094254801 @default.
• W4320730400 cites W2094955667 @default.
• W4320730400 cites W2096352923 @default.
• W4320730400 cites W2098398184 @default.
• W4320730400 cites W2109355862 @default.
• W4320730400 cites W2109740270 @default.
• W4320730400 cites W2112011558 @default.
• W4320730400 cites W2115475740 @default.
• W4320730400 cites W2117196163 @default.
• W4320730400 cites W2119527577 @default.
• W4320730400 cites W2119768071 @default.
• W4320730400 cites W2121616521 @default.
• W4320730400 cites W2127314696 @default.
• W4320730400 cites W2131604435 @default.
• W4320730400 cites W2144851538 @default.
• W4320730400 cites W2149146712 @default.
• W4320730400 cites W2150177691 @default.
• W4320730400 cites W2161399617 @default.
• W4320730400 cites W2161778307 @default.
• W4320730400 cites W2175729515 @default.
• W4320730400 cites W2341724094 @default.
• W4320730400 cites W2401152555 @default.
• W4320730400 cites W2410812192 @default.
• W4320730400 cites W2411823338 @default.
• W4320730400 cites W2587681015 @default.
• W4320730400 cites W2588660617 @default.
• W4320730400 cites W2754494476 @default.
• W4320730400 cites W2802435570 @default.
• W4320730400 cites W2806961305 @default.
• W4320730400 cites W2884388698 @default.
• W4320730400 cites W2884860527 @default.
• W4320730400 cites W2891729799 @default.
• W4320730400 cites W2900845670 @default.
• W4320730400 cites W2972986412 @default.
• W4320730400 cites W2996679512 @default.
• W4320730400 cites W3015177139 @default.
• W4320730400 cites W3016938917 @default.
• W4320730400 cites W3020455905 @default.
• W4320730400 cites W3032720282 @default.
• W4320730400 cites W3112091833 @default.
• W4320730400 cites W3116622806 @default.
• W4320730400 cites W3139127871 @default.
• W4320730400 cites W3173933823 @default.
• W4320730400 cites W3209979520 @default.
• W4320730400 cites W326443903 @default.
• W4320730400 doi "https://doi.org/10.1038/s41440-023-01189-y" @default.
• W4320730400 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36788301" @default.
• W4320730400 hasPublicationYear "2023" @default.

• next