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- W4320730875 abstract "Sepsis, which is a systemic inflammatory response syndrome caused by infection, has high morbidity and mortality. Sepsis-related liver injury is one of the manifestations of sepsis-induced multiple organ syndrome. To date, an increasing number of studies have shown that the hepatic inflammatory response, oxidative stress, microcirculation coagulation dysfunction, and bacterial translocation play extremely vital roles in the occurrence and development of sepsis-related liver injury. In the clinic, sepsis-related liver injury is mainly treated by routine empirical methods on the basis of the primary disease. However, these therapies have some shortcomings, such as serious side effects, short duration of drug effects and lack of specificity. The emergence of drug delivery nanosystems can significantly improve drug bioavailability and reduce toxic side effects. In this paper, we reviewed drug delivery nanosystems designed for the treatment of sepsis-related liver injury according to their mechanisms (hepatic inflammation response, oxidative stress, coagulation dysfunction in the microcirculation, and bacterial translocation). Although much promising progress has been achieved, translation into clinical practice is still difficult. To this end, we also discussed the key issues currently facing this field, including immune system rejection and single treatment modalities. Finally, with the rigorous optimization of nanotechnology and the deepening of research, drug delivery nanosystems have great potential for the treatment of sepsis-related liver injury." @default.
- W4320730875 created "2023-02-15" @default.
- W4320730875 creator A5009872479 @default.
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- W4320730875 creator A5085524974 @default.
- W4320730875 creator A5086500887 @default.
- W4320730875 date "2023-02-01" @default.
- W4320730875 modified "2023-09-29" @default.
- W4320730875 title "An Overview of Drug Delivery Nanosystems for Sepsis-Related Liver Injury Treatment" @default.
- W4320730875 cites W1564553363 @default.
- W4320730875 cites W1979020653 @default.
- W4320730875 cites W2029207036 @default.
- W4320730875 cites W2060122053 @default.
- W4320730875 cites W2144320236 @default.
- W4320730875 cites W2146247881 @default.
- W4320730875 cites W2151372281 @default.
- W4320730875 cites W2152925634 @default.
- W4320730875 cites W2236485451 @default.
- W4320730875 cites W2314893679 @default.
- W4320730875 cites W2553537041 @default.
- W4320730875 cites W2567040191 @default.
- W4320730875 cites W2570675177 @default.
- W4320730875 cites W2595378874 @default.
- W4320730875 cites W2600575351 @default.
- W4320730875 cites W2689318812 @default.
- W4320730875 cites W2739873258 @default.
- W4320730875 cites W2744926357 @default.
- W4320730875 cites W2769799079 @default.
- W4320730875 cites W2781570653 @default.
- W4320730875 cites W2792029853 @default.
- W4320730875 cites W2793373748 @default.
- W4320730875 cites W2801153970 @default.
- W4320730875 cites W2803015713 @default.
- W4320730875 cites W2804243706 @default.
- W4320730875 cites W2810427028 @default.
- W4320730875 cites W2886620535 @default.
- W4320730875 cites W2890443562 @default.
- W4320730875 cites W2890794064 @default.
- W4320730875 cites W2893420719 @default.
- W4320730875 cites W2894892175 @default.
- W4320730875 cites W2900829229 @default.
- W4320730875 cites W2902710654 @default.
- W4320730875 cites W2914632596 @default.
- W4320730875 cites W2916069845 @default.
- W4320730875 cites W2920862005 @default.
- W4320730875 cites W2921595616 @default.
- W4320730875 cites W2955283253 @default.
- W4320730875 cites W2964066412 @default.
- W4320730875 cites W2964930843 @default.
- W4320730875 cites W2969499889 @default.
- W4320730875 cites W2971520267 @default.
- W4320730875 cites W2985512580 @default.
- W4320730875 cites W2988051443 @default.
- W4320730875 cites W2990511615 @default.
- W4320730875 cites W2991127841 @default.
- W4320730875 cites W2991604646 @default.
- W4320730875 cites W2998275193 @default.
- W4320730875 cites W2998535942 @default.
- W4320730875 cites W2998853022 @default.
- W4320730875 cites W2999588157 @default.
- W4320730875 cites W3002686604 @default.
- W4320730875 cites W3003209420 @default.
- W4320730875 cites W3003236435 @default.
- W4320730875 cites W3007123356 @default.
- W4320730875 cites W3011398176 @default.
- W4320730875 cites W3013053131 @default.
- W4320730875 cites W3016829704 @default.
- W4320730875 cites W3017035981 @default.
- W4320730875 cites W3017087303 @default.
- W4320730875 cites W3030796652 @default.
- W4320730875 cites W3037460005 @default.
- W4320730875 cites W3039435592 @default.
- W4320730875 cites W3042528727 @default.
- W4320730875 cites W3044869633 @default.
- W4320730875 cites W3047700115 @default.
- W4320730875 cites W3048086500 @default.
- W4320730875 cites W3080736968 @default.
- W4320730875 cites W3081689944 @default.
- W4320730875 cites W3081790187 @default.
- W4320730875 cites W3084979427 @default.
- W4320730875 cites W3089560419 @default.
- W4320730875 cites W3091651761 @default.
- W4320730875 cites W3093138997 @default.
- W4320730875 cites W3093454800 @default.
- W4320730875 cites W3099567402 @default.
- W4320730875 cites W3101496829 @default.
- W4320730875 cites W3107901939 @default.
- W4320730875 cites W3108653009 @default.
- W4320730875 cites W3113341141 @default.
- W4320730875 cites W3116848577 @default.
- W4320730875 cites W3117541877 @default.
- W4320730875 cites W3118814234 @default.
- W4320730875 cites W3128260795 @default.
- W4320730875 cites W3134372233 @default.
- W4320730875 cites W3136688190 @default.