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- W4320732364 endingPage "1785" @default.
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- W4320732364 abstract "Some of the more than 350 Scutellaria species, such as S. baicalensis and S. lateriflora, have been used in traditional medicine and today play an important role in official phytotherapy. Other species have been less investigated, and their therapeutic potential is unknown. This is one of the few studies on Scutellaria brevibracteata subsp. subvelutina, and the first research of this species' in vitro cultures. The aim of this study was to establish an in vitro culture and analyse its phytochemical profile and biological activity. In the methanolic extracts from biomass cultured on six solid Murashige and Skoog (MS) medium variants supplemented with different combinations of 6-benzylaminopurine (BAP) and 1-naphthaleneacetic acid (NAA) in the range 0.5-3 mg/L analysed by HPLC, the presence of specific flavonoids (baicalein, baicalin, wogonin, wogonoside, scutellarin, chrysin), phenylpropanoid glycosides (verbascoside, isoverbascoside), and phenolic acids (p-hydroxybenzoic, caffeic, ferulic, m-coumaric acids) was confirmed. The dominant metabolites were wogonoside and verbascoside with the highest content of 346 and 457 mg/100 g DW, respectively. Thus, the extract with the highest content of bioactive metabolites was selected for further research and subjected to evaluation of antioxidant and antimicrobial potential. The extract exhibited good free radical scavenging activity (IC50 = 0.92 ± 0.01 mg/mL) and moderate reducing power and chelating activity. The brine shrimp lethality bioassay proved its lack of biotoxicity. Antimicrobial activity was tested against sixteen strains of Gram-positive and Gram-negative bacteria and fungi. The strongest growth inhibitory activity was observed against Trichophyton tonsurans." @default.
- W4320732364 created "2023-02-15" @default.
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- W4320732364 date "2023-02-14" @default.
- W4320732364 modified "2023-10-18" @default.
- W4320732364 title "In Vitro Cultures of Scutellaria brevibracteata subsp. subvelutina as a Source of Bioactive Phenolic Metabolites" @default.
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- W4320732364 cites W1974575214 @default.
- W4320732364 cites W1989220608 @default.
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- W4320732364 cites W2014399151 @default.
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- W4320732364 cites W2021995332 @default.
- W4320732364 cites W2022040093 @default.
- W4320732364 cites W2024405339 @default.
- W4320732364 cites W2024556021 @default.
- W4320732364 cites W2025404024 @default.
- W4320732364 cites W2026022139 @default.
- W4320732364 cites W2026202254 @default.
- W4320732364 cites W2032456864 @default.
- W4320732364 cites W2033234573 @default.
- W4320732364 cites W2034485827 @default.
- W4320732364 cites W2043043846 @default.
- W4320732364 cites W2046475321 @default.
- W4320732364 cites W2048089945 @default.
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- W4320732364 cites W2144093850 @default.
- W4320732364 cites W2151712916 @default.
- W4320732364 cites W2337489174 @default.
- W4320732364 cites W2410234461 @default.
- W4320732364 cites W2468178855 @default.
- W4320732364 cites W2473631582 @default.
- W4320732364 cites W2553657892 @default.
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- W4320732364 cites W2903038942 @default.
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- W4320732364 cites W2925456894 @default.
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- W4320732364 cites W3043815833 @default.
- W4320732364 cites W3046098691 @default.
- W4320732364 cites W3048658308 @default.
- W4320732364 cites W3098714672 @default.
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- W4320732364 cites W4213216442 @default.
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- W4320732364 doi "https://doi.org/10.3390/molecules28041785" @default.
- W4320732364 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36838774" @default.
- W4320732364 hasPublicationYear "2023" @default.
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