Matches in SemOpenAlex for { <https://semopenalex.org/work/W4320733588> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W4320733588 abstract "Abstract Background: The incidence of non-alcoholic fatty liver disease (NAFLD) is rising in parallel with increasing bodyweight and loss of glucose control, implicating a high risk of hepatic and extra-hepatic complications. Subjects / Methods: This longitudinal observational study analysed several indicators for NAFLD in 240 overweight subjects (body mass index (BMI) > 28 kg/m²) at 2 visits within in average 16 months. Subjects were categorised according to their insulin sensitivity (HOMAIR) and diabetic status. Methods: Liver fat and liver stiffness were measured with sonographic elastography (FibroScan®), and by calculation of Fatty Liver Index (FLI), and NAFLD Fibrosis Score (NFS). Results: Parameters indicative for liver steatosis, i.e., the controlled attenuation parameter (CAP) and the FLI, were significantly higher in the T2DM group compared to the normal glucose tolerance (NGT) and impaired glucose tolerance (IGT) groups (p<0.05). FLI values and the HOMAIR significantly correlated with sonographic liver fat content (CAP) (r=0.53, p<0.0001; r=0.34, p<0.001, respectively). An inverse correlation was observed between serum adiponectin levels and CAP (r=-0.20; p<0.019) and adiponectin levels and FLI (r=-0.37; p<0.0001). Over 16 months, fasting insulin levels and HOMAIR score increased mainly driven by the group of obese subjects with T2DM. No significant change in liver fat or stiffness was observed that period. Conclusions: In subjects with a BMI ≥ 28kg/m², the prevalence of NAFLD increases in line with increasing insulin resistance and loss of glucose control. Despite some ongoing deterioration in insulin sensitivity, liver fat content appeared relatively unchanged over 16 months." @default.
- W4320733588 created "2023-02-15" @default.
- W4320733588 creator A5011213764 @default.
- W4320733588 creator A5016557741 @default.
- W4320733588 creator A5026718251 @default.
- W4320733588 creator A5044778195 @default.
- W4320733588 creator A5046230967 @default.
- W4320733588 creator A5053247699 @default.
- W4320733588 creator A5082019875 @default.
- W4320733588 date "2023-02-14" @default.
- W4320733588 modified "2023-10-17" @default.
- W4320733588 title "Non-Alcoholic Fatty Liver in Obesity with Deteriorating Glucose Control" @default.
- W4320733588 cites W1622799587 @default.
- W4320733588 cites W1968441810 @default.
- W4320733588 cites W2017918734 @default.
- W4320733588 cites W2043412879 @default.
- W4320733588 cites W2046913258 @default.
- W4320733588 cites W2051183593 @default.
- W4320733588 cites W2058886213 @default.
- W4320733588 cites W2077963393 @default.
- W4320733588 cites W2111946630 @default.
- W4320733588 cites W2147721510 @default.
- W4320733588 cites W2160234571 @default.
- W4320733588 cites W2163552603 @default.
- W4320733588 cites W2168216817 @default.
- W4320733588 cites W2942227779 @default.
- W4320733588 cites W2984764470 @default.
- W4320733588 cites W3015579983 @default.
- W4320733588 cites W3044005771 @default.
- W4320733588 cites W3044271696 @default.
- W4320733588 cites W3143409077 @default.
- W4320733588 cites W3210697821 @default.
- W4320733588 cites W3214293028 @default.
- W4320733588 cites W4206332157 @default.
- W4320733588 doi "https://doi.org/10.21203/rs.3.rs-2393464/v2" @default.
- W4320733588 hasPublicationYear "2023" @default.
- W4320733588 type Work @default.
- W4320733588 citedByCount "0" @default.
- W4320733588 crossrefType "posted-content" @default.
- W4320733588 hasAuthorship W4320733588A5011213764 @default.
- W4320733588 hasAuthorship W4320733588A5016557741 @default.
- W4320733588 hasAuthorship W4320733588A5026718251 @default.
- W4320733588 hasAuthorship W4320733588A5044778195 @default.
- W4320733588 hasAuthorship W4320733588A5046230967 @default.
- W4320733588 hasAuthorship W4320733588A5053247699 @default.
- W4320733588 hasAuthorship W4320733588A5082019875 @default.
- W4320733588 hasBestOaLocation W43207335881 @default.
- W4320733588 hasConcept C126322002 @default.
- W4320733588 hasConcept C134018914 @default.
- W4320733588 hasConcept C2776175330 @default.
- W4320733588 hasConcept C2776782570 @default.
- W4320733588 hasConcept C2776954865 @default.
- W4320733588 hasConcept C2777214474 @default.
- W4320733588 hasConcept C2777391703 @default.
- W4320733588 hasConcept C2778772119 @default.
- W4320733588 hasConcept C2779134260 @default.
- W4320733588 hasConcept C2780221984 @default.
- W4320733588 hasConcept C2780586474 @default.
- W4320733588 hasConcept C2780609358 @default.
- W4320733588 hasConcept C2780826214 @default.
- W4320733588 hasConcept C2994217296 @default.
- W4320733588 hasConcept C511355011 @default.
- W4320733588 hasConcept C71924100 @default.
- W4320733588 hasConceptScore W4320733588C126322002 @default.
- W4320733588 hasConceptScore W4320733588C134018914 @default.
- W4320733588 hasConceptScore W4320733588C2776175330 @default.
- W4320733588 hasConceptScore W4320733588C2776782570 @default.
- W4320733588 hasConceptScore W4320733588C2776954865 @default.
- W4320733588 hasConceptScore W4320733588C2777214474 @default.
- W4320733588 hasConceptScore W4320733588C2777391703 @default.
- W4320733588 hasConceptScore W4320733588C2778772119 @default.
- W4320733588 hasConceptScore W4320733588C2779134260 @default.
- W4320733588 hasConceptScore W4320733588C2780221984 @default.
- W4320733588 hasConceptScore W4320733588C2780586474 @default.
- W4320733588 hasConceptScore W4320733588C2780609358 @default.
- W4320733588 hasConceptScore W4320733588C2780826214 @default.
- W4320733588 hasConceptScore W4320733588C2994217296 @default.
- W4320733588 hasConceptScore W4320733588C511355011 @default.
- W4320733588 hasConceptScore W4320733588C71924100 @default.
- W4320733588 hasLocation W43207335881 @default.
- W4320733588 hasOpenAccess W4320733588 @default.
- W4320733588 hasPrimaryLocation W43207335881 @default.
- W4320733588 hasRelatedWork W2017554448 @default.
- W4320733588 hasRelatedWork W2022264206 @default.
- W4320733588 hasRelatedWork W2043204211 @default.
- W4320733588 hasRelatedWork W2044823377 @default.
- W4320733588 hasRelatedWork W2124038922 @default.
- W4320733588 hasRelatedWork W2128482911 @default.
- W4320733588 hasRelatedWork W2169206971 @default.
- W4320733588 hasRelatedWork W2371483602 @default.
- W4320733588 hasRelatedWork W2627051096 @default.
- W4320733588 hasRelatedWork W3028839963 @default.
- W4320733588 isParatext "false" @default.
- W4320733588 isRetracted "false" @default.
- W4320733588 workType "article" @default.