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- W4320804002 abstract "The Human Immunodeficiency Virus has been affecting people for years. Leading patients to acquire several other diseases due to weakening of the immune system. The use of metabolites from marine algae have antiviral activities. Therefore, this work analyzed among 40 molecules, originating from algae, through in silico techniques, with the objective of proposing a promising molecule with possible HIV inhibitory activity. The disease caused by the Human Immunodeficiency Virus (HIV) has infected people for over 50 years. Currently, 37.7 million people live with the virus, among these 150,000 people were infected with the HIV virus only in the year 2020, in addition 73% of people use drug therapy with retrovirals. Therefore, it is important to investigate new possible drugs, one of these ways is through computational techniques.The oceans have an enormous biodiversity, with biological sources rich in bioactive molecules, since the pharmaceutical and cosmetic industries seek technological innovations, numerous marine sources have been the object of study.Among these are marine algae that are divided into macroscopic and microscopic. Both are rich in secondary metabolites that have great pharmacological potential. Seaweeds already have several studies on their broad biological activities such as: antimicrobial, anticancer, antiallergic, antioxidant, anticoagulant, antidiabetic, antiparasitic, anti-inflammatory and antiviral.Thus, this work aimed to analyze the possible inhibitory activity of molecules present in seaweeds in proteins present in HIV." @default.
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- W4320804002 date "2022-03-29" @default.
- W4320804002 modified "2023-10-16" @default.
- W4320804002 title "Prediction of antiviral activity, cytotoxicity risks and molecular docking against HIV of constituents from marine algae" @default.
- W4320804002 doi "https://doi.org/10.3390/mol2net-08-12455" @default.
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