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• W4320814158 abstract "The role of the spatial organization of chromosomes in directing transcription remains an outstanding question in gene regulation. Here, we analyze two recent single-cell imaging methodologies applied across hundreds of genes to systematically analyze the contribution of chromosome conformation to transcriptional regulation. Those methodologies are (1) single-cell chromatin tracing with super-resolution imaging in fixed cells; and (2) high-throughput labeling and imaging of nascent RNA in living cells. Specifically, we determine the contribution of physical distance to the coordination of transcriptional bursts. We find that individual genes adopt a constrained conformation and reposition toward the centroid of the surrounding chromatin upon activation. Leveraging the variability in distance inherent in single-cell imaging, we show that physical distance - but not genomic distance - between genes on individual chromosomes is the major factor driving co-bursting. By combining this analysis with live-cell imaging, we arrive at a corrected transcriptional correlation of [Formula: see text] for genes separated by < 400 nm. We propose that this surprisingly large correlation represents a physical property of human chromosomes and establishes a benchmark for future experimental studies." @default.
• W4320814158 created "2023-02-15" @default.
• W4320814158 creator A5074829724 @default.
• W4320814158 creator A5088617006 @default.
• W4320814158 date "2023-02-15" @default.
• W4320814158 modified "2023-10-12" @default.
• W4320814158 title "Synthetic analysis of chromatin tracing and live-cell imaging indicates pervasive spatial coupling between genes" @default.
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• W4320814158 doi "https://doi.org/10.7554/elife.81861" @default.
• W4320814158 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36790144" @default.
• W4320814158 hasPublicationYear "2023" @default.
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