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- W4320856598 abstract "Background: Our group have recently reported that there is no evidence of an associa-tion between fibromyalgia and Borrelia-specific T lymphocytes. However, a small number of case reports has suggested that infection by the bacterial genus Borrelia may be associated with the pres-ence of antinuclear antibodies (ANAs). Objective: To test the hypothesis that those fibromyalgia patients who are ANA seropositive are more likely to show evidence of Borrelia-specific T lymphocyte reactivity than those who are sero-negative. Methods: T lymphocyte reactivity to Borrelia burgdorferi sensu stricto (full antigen) was assessed using the enzyme-linked immunospot and serum ANA status was assessed using immunofluores-cence in 27 fibromyalgia patients fulfilling the revised diagnostic criteria of the American College of Rheumatology. Results: The ANA seropositive and seronegative groups were matched for age, sex and ethnicity; the T lymphocyte reactivity to Borrelia burgdorferi sensu stricto (full antigen) in the former group (mean 5.60) was significantly higher than that in the seronegative group (mean 1.77; p < 0.05). Conclusion: This novel study points to an association of ANA seropositivity in fibromyalgia with Borrelia-specific T lymphocytes." @default.
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- W4320856598 date "2023-08-01" @default.
- W4320856598 modified "2023-09-27" @default.
- W4320856598 title "Antinuclear Antibody Seropositivity in Fibromyalgia Associated with Borrelia-specific T Lymphocytes" @default.
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- W4320856598 doi "https://doi.org/10.2174/1573397119666230215124048" @default.
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