Matches in SemOpenAlex for { <https://semopenalex.org/work/W4320857337> ?p ?o ?g. }
- W4320857337 abstract "Abstract Herein, we disclose the highly enantioselective oxidative cross‐coupling of 3‐hydroxyindole esters with various nucleophilic partners as catalyzed by copper efflux oxidase. The biocatalytic transformation delivers functionalized 2,2‐disubstituted indolin‐3‐ones with excellent optical purity (90–99 % ee ), which exhibited anticancer activity against MCF‐7 cell lines, as shown by preliminary biological evaluation. Mechanistic studies and molecular docking results suggest the formation of a phenoxyl radical and enantiocontrol facilitated by a suited enzyme chiral pocket. This study is significant with regard to expanding the catalytic repertoire of natural multicopper oxidases as well as enlarging the synthetic toolbox for sustainable asymmetric oxidative coupling." @default.
- W4320857337 created "2023-02-16" @default.
- W4320857337 creator A5009024648 @default.
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- W4320857337 creator A5085155960 @default.
- W4320857337 creator A5089732894 @default.
- W4320857337 date "2023-03-08" @default.
- W4320857337 modified "2023-10-18" @default.
- W4320857337 title "Expanding the Promiscuity of a Copper‐Dependent Oxidase for Enantioselective Cross‐Coupling of Indoles" @default.
- W4320857337 cites W1963854859 @default.
- W4320857337 cites W1975270025 @default.
- W4320857337 cites W1982558875 @default.
- W4320857337 cites W2001596085 @default.
- W4320857337 cites W2010929717 @default.
- W4320857337 cites W2014132113 @default.
- W4320857337 cites W2017697053 @default.
- W4320857337 cites W2018224890 @default.
- W4320857337 cites W2023343774 @default.
- W4320857337 cites W2028291957 @default.
- W4320857337 cites W2036502756 @default.
- W4320857337 cites W2036551860 @default.
- W4320857337 cites W2044788577 @default.
- W4320857337 cites W2074473216 @default.
- W4320857337 cites W2078531329 @default.
- W4320857337 cites W2092781147 @default.
- W4320857337 cites W2106487925 @default.
- W4320857337 cites W2110198171 @default.
- W4320857337 cites W2112842204 @default.
- W4320857337 cites W2121250706 @default.
- W4320857337 cites W2128434938 @default.
- W4320857337 cites W2132547201 @default.
- W4320857337 cites W2135410886 @default.
- W4320857337 cites W2142319090 @default.
- W4320857337 cites W2156782854 @default.
- W4320857337 cites W2179327649 @default.
- W4320857337 cites W2329076747 @default.
- W4320857337 cites W2330831719 @default.
- W4320857337 cites W2422971254 @default.
- W4320857337 cites W2490607713 @default.
- W4320857337 cites W2552441723 @default.
- W4320857337 cites W2558397050 @default.
- W4320857337 cites W2768252314 @default.
- W4320857337 cites W2789304833 @default.
- W4320857337 cites W2790493352 @default.
- W4320857337 cites W2791848541 @default.
- W4320857337 cites W2796309353 @default.
- W4320857337 cites W2801612223 @default.
- W4320857337 cites W2810361637 @default.
- W4320857337 cites W2905500176 @default.
- W4320857337 cites W2928739318 @default.
- W4320857337 cites W2943015857 @default.
- W4320857337 cites W2943126044 @default.
- W4320857337 cites W2987964167 @default.
- W4320857337 cites W2999044305 @default.
- W4320857337 cites W3002774878 @default.
- W4320857337 cites W3002973239 @default.
- W4320857337 cites W3004194370 @default.
- W4320857337 cites W3033463761 @default.
- W4320857337 cites W3082227498 @default.
- W4320857337 cites W3116036678 @default.
- W4320857337 cites W3122445055 @default.
- W4320857337 cites W3128028223 @default.
- W4320857337 cites W3128731103 @default.
- W4320857337 cites W3129811715 @default.
- W4320857337 cites W3140445838 @default.
- W4320857337 cites W3149409490 @default.
- W4320857337 cites W3153152948 @default.
- W4320857337 cites W3155222100 @default.
- W4320857337 cites W3185550634 @default.
- W4320857337 cites W3186495012 @default.
- W4320857337 cites W3187446781 @default.
- W4320857337 cites W3194417623 @default.
- W4320857337 cites W3197962714 @default.
- W4320857337 cites W3198800492 @default.
- W4320857337 cites W3201655550 @default.
- W4320857337 cites W3203310176 @default.
- W4320857337 cites W4200064233 @default.
- W4320857337 cites W4200187979 @default.
- W4320857337 cites W4200189387 @default.
- W4320857337 cites W4205389010 @default.
- W4320857337 cites W4213047970 @default.
- W4320857337 cites W4214518487 @default.
- W4320857337 cites W4220749138 @default.
- W4320857337 cites W4224243487 @default.
- W4320857337 cites W4226137674 @default.
- W4320857337 cites W4229036473 @default.
- W4320857337 cites W4231382921 @default.
- W4320857337 cites W4237817571 @default.
- W4320857337 cites W4238445808 @default.
- W4320857337 cites W4241702465 @default.
- W4320857337 cites W4244913553 @default.
- W4320857337 cites W4248318747 @default.
- W4320857337 cites W4248649629 @default.