FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4320857510> ?p ?o ?g. }

• W4320857510 endingPage "251" @default.
• W4320857510 startingPage "241" @default.
• W4320857510 abstract "The purpose of this study was to investigate the efficacy of cariprazine, a dopamine D3-preferring D3/D2 and serotonin 5-HT1A receptor partial agonist, as adjunctive therapy for patients with major depressive disorder and nonresponse to at least one antidepressant monotherapy.In this double-blind placebo-controlled study, adults with major depressive disorder and inadequate response to antidepressants alone were randomized in a 1:1:1 ratio to placebo, cariprazine at 1.5 mg/day, or cariprazine at 3.0 mg/day. The primary outcome was change from baseline to week 6 in total score on the Montgomery-Åsberg Depression Rating Scale (MADRS). Least-squares mean differences were estimated in the modified intent-to-treat (mITT) population using a mixed-effects model for repeated measures with adjustment for multiple comparisons.The mITT population comprised 751 patients (placebo: N=249; cariprazine 1.5 mg/day: N=250; cariprazine 3.0 mg/day: N=252). At week 6, the mean reduction from baseline in MADRS total score was significantly greater with cariprazine 1.5 mg/day than with placebo (-14.1 vs. -11.5) but not with cariprazine 3.0 mg/day (-13.1). Significant differences between the cariprazine 1.5 mg/day and placebo groups were also observed at weeks 2 and 4. Meeting the MADRS response criteria was significantly more likely among patients receiving cariprazine 1.5 mg/day than placebo (44.0% vs. 34.9%); remission rates were not significantly different among groups. Common treatment-emergent adverse events (≥5% in either cariprazine group and twice the placebo rate) were akathisia and nausea.Adjunctive cariprazine at 1.5 mg/day demonstrated efficacy in reducing depressive symptoms in adults with major depressive disorder and inadequate response to antidepressants alone. Cariprazine was generally well tolerated, with a safety profile that was consistent with previous findings." @default.
• W4320857510 created "2023-02-16" @default.
• W4320857510 creator A5000732368 @default.
• W4320857510 creator A5019830062 @default.
• W4320857510 creator A5039886247 @default.
• W4320857510 creator A5040882829 @default.
• W4320857510 creator A5048319720 @default.
• W4320857510 creator A5084024326 @default.
• W4320857510 date "2023-03-01" @default.
• W4320857510 modified "2023-09-30" @default.
• W4320857510 title "Adjunctive Cariprazine for the Treatment of Patients With Major Depressive Disorder: A Randomized, Double-Blind, Placebo-Controlled Phase 3 Study" @default.
• W4320857510 cites W1966424565 @default.
• W4320857510 cites W1999689270 @default.
• W4320857510 cites W2049571898 @default.
• W4320857510 cites W2064070148 @default.
• W4320857510 cites W2073526412 @default.
• W4320857510 cites W2076675985 @default.
• W4320857510 cites W2087557453 @default.
• W4320857510 cites W2087912588 @default.
• W4320857510 cites W2104518967 @default.
• W4320857510 cites W2111663098 @default.
• W4320857510 cites W2114613490 @default.
• W4320857510 cites W2123599105 @default.
• W4320857510 cites W2131823335 @default.
• W4320857510 cites W2132324173 @default.
• W4320857510 cites W2135166041 @default.
• W4320857510 cites W2148083007 @default.
• W4320857510 cites W2149402043 @default.
• W4320857510 cites W2150458484 @default.
• W4320857510 cites W2160070901 @default.
• W4320857510 cites W2165379748 @default.
• W4320857510 cites W2167223183 @default.
• W4320857510 cites W2167659819 @default.
• W4320857510 cites W2237698880 @default.
• W4320857510 cites W2316471784 @default.
• W4320857510 cites W2514999534 @default.
• W4320857510 cites W2559328180 @default.
• W4320857510 cites W2619718464 @default.
• W4320857510 cites W2735979276 @default.
• W4320857510 cites W2789034326 @default.
• W4320857510 cites W2883561153 @default.
• W4320857510 cites W2901166889 @default.
• W4320857510 cites W2905349616 @default.
• W4320857510 cites W2909040240 @default.
• W4320857510 cites W2921930118 @default.
• W4320857510 cites W2957698583 @default.
• W4320857510 cites W2980904631 @default.
• W4320857510 cites W948132221 @default.
• W4320857510 doi "https://doi.org/10.1176/appi.ajp.20220504" @default.
• W4320857510 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36789515" @default.
• W4320857510 hasPublicationYear "2023" @default.
• W4320857510 type Work @default.
• W4320857510 citedByCount "4" @default.
• W4320857510 countsByYear W43208575102023 @default.
• W4320857510 crossrefType "journal-article" @default.
• W4320857510 hasAuthorship W4320857510A5000732368 @default.
• W4320857510 hasAuthorship W4320857510A5019830062 @default.
• W4320857510 hasAuthorship W4320857510A5039886247 @default.
• W4320857510 hasAuthorship W4320857510A5040882829 @default.
• W4320857510 hasAuthorship W4320857510A5048319720 @default.
• W4320857510 hasAuthorship W4320857510A5084024326 @default.
• W4320857510 hasConcept C126322002 @default.
• W4320857510 hasConcept C142724271 @default.
• W4320857510 hasConcept C15744967 @default.
• W4320857510 hasConcept C170493617 @default.
• W4320857510 hasConcept C204787440 @default.
• W4320857510 hasConcept C27081682 @default.
• W4320857510 hasConcept C2778938600 @default.
• W4320857510 hasConcept C2779144063 @default.
• W4320857510 hasConcept C2780051608 @default.
• W4320857510 hasConcept C2908647359 @default.
• W4320857510 hasConcept C58732023 @default.
• W4320857510 hasConcept C71924100 @default.
• W4320857510 hasConcept C99454951 @default.
• W4320857510 hasConceptScore W4320857510C126322002 @default.
• W4320857510 hasConceptScore W4320857510C142724271 @default.
• W4320857510 hasConceptScore W4320857510C15744967 @default.
• W4320857510 hasConceptScore W4320857510C170493617 @default.
• W4320857510 hasConceptScore W4320857510C204787440 @default.
• W4320857510 hasConceptScore W4320857510C27081682 @default.
• W4320857510 hasConceptScore W4320857510C2778938600 @default.
• W4320857510 hasConceptScore W4320857510C2779144063 @default.
• W4320857510 hasConceptScore W4320857510C2780051608 @default.
• W4320857510 hasConceptScore W4320857510C2908647359 @default.
• W4320857510 hasConceptScore W4320857510C58732023 @default.
• W4320857510 hasConceptScore W4320857510C71924100 @default.
• W4320857510 hasConceptScore W4320857510C99454951 @default.
• W4320857510 hasIssue "3" @default.
• W4320857510 hasLocation W43208575101 @default.
• W4320857510 hasLocation W43208575102 @default.
• W4320857510 hasOpenAccess W4320857510 @default.
• W4320857510 hasPrimaryLocation W43208575101 @default.
• W4320857510 hasRelatedWork W2038126519 @default.
• W4320857510 hasRelatedWork W2056356983 @default.
• W4320857510 hasRelatedWork W2091850145 @default.
• W4320857510 hasRelatedWork W2149817753 @default.
• W4320857510 hasRelatedWork W2192384793 @default.
• W4320857510 hasRelatedWork W2748952813 @default.

• next