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• W4320857513 abstract "Recently, three proton channels (H V ) have been identified and characterized in Aplysia californica (AcH V 1‐3). Focusing on AcH V 1 and AcH V 2, analysis of Transcriptome Shotgun Assembly and genomic databases of 91 molluscs identified H V homologous channels in other molluscs: channels homologous to AcH V 1 and to AcH V 2 were found in 90 species (56 full‐length sequences) and in 33 species (18 full‐length sequences), respectively. Here, we report the discovery of a fourth distinct proton channel family, H V 4. This new family has high homology to AcH V 1 and AcH V 2 and was identified only in bivalvian molluscs (13 species, 12 full‐length sequences). Typically, these channels possess an extracellular S1–S2 loop of intermediate size (~ 20 amino acids) compared to the shorter loops of molluscan H V 1 channels (~ 13 amino acids) and the much larger loops of molluscan H V 2 channels (> 65 amino acids). The characteristic voltage‐sensor motif in S4 possesses only two arginine residues with the common third arginine being replaced by a lysine. Moreover, H V 4 channels are much smaller with only around 200 amino acids in total length. The smallest functional channel found so far in nature (189 amino acids) is expressed in the pacific oyster Crassostrea gigas (CgH V 4) and might be considered an archetypical minimal proton channel. Functional expression and electrophysiological characterization demonstrated that CgH V 4 shares distinctive hallmarks of other investigated proton channels as high proton selectivity, slow activation, and pH‐ and voltage‐regulated gating. This work is the first description of a H V 4 type channel, adding a new member to the recently expanded family of proton channels." @default.
• W4320857513 created "2023-02-16" @default.
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• W4320857513 date "2023-03-03" @default.
• W4320857513 modified "2023-09-25" @default.
• W4320857513 title "Proton channels in molluscs: A new bivalvian‐specific minimal H_V4 channel" @default.
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• W4320857513 doi "https://doi.org/10.1111/febs.16751" @default.
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