Matches in SemOpenAlex for { <https://semopenalex.org/work/W4320879159> ?p ?o ?g. }
- W4320879159 endingPage "114395" @default.
- W4320879159 startingPage "114395" @default.
- W4320879159 abstract "Colorectal cancer (CRC) is a dangerous form of cancer that affects the gastrointestinal tract. It is a major global health concern, and the aggressive behavior of tumor cells makes it difficult to treat, leading to poor survival rates for patients. One major challenge in treating CRC is the metastasis, or spread, of the cancer, which is a major cause of death. In order to improve the prognosis for patients with CRC, it is necessary to focus on ways to inhibit the cancer's ability to invade and spread. Epithelial-mesenchymal transition (EMT) is a process that is linked to the spread of cancer cells, also known as metastasis. The process transforms epithelial cells into mesenchymal ones, increasing their mobility and ability to invade other tissues. This has been shown to be a key mechanism in the progression of colorectal cancer (CRC), a particularly aggressive form of gastrointestinal cancer. The activation of EMT leads to increases in the spread of CRC cells, and during this process, levels of the protein E-cadherin decrease while levels of N-cadherin and vimentin increase. EMT also contributes to the development of resistance to chemotherapy and radiation therapy in CRC. Non-coding RNAs, such as long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs), play a role in regulating EMT in CRC, often through their ability to sponge microRNAs. Anti-cancer agents have been shown to suppress EMT and reduce the progression and spread of CRC cells. These findings suggest that targeting EMT or related mechanisms may be a promising approach for treating CRC patients in the clinic." @default.
- W4320879159 created "2023-02-16" @default.
- W4320879159 creator A5007782624 @default.
- W4320879159 creator A5013269604 @default.
- W4320879159 creator A5013368102 @default.
- W4320879159 creator A5014512828 @default.
- W4320879159 creator A5016407701 @default.
- W4320879159 creator A5018878563 @default.
- W4320879159 creator A5028415995 @default.
- W4320879159 creator A5039650932 @default.
- W4320879159 creator A5041093222 @default.
- W4320879159 creator A5044842109 @default.
- W4320879159 creator A5048072123 @default.
- W4320879159 creator A5070231568 @default.
- W4320879159 creator A5078858622 @default.
- W4320879159 creator A5079361709 @default.
- W4320879159 creator A5079811196 @default.
- W4320879159 creator A5081085894 @default.
- W4320879159 creator A5086128324 @default.
- W4320879159 creator A5087812545 @default.
- W4320879159 date "2023-04-01" @default.
- W4320879159 modified "2023-10-03" @default.
- W4320879159 title "Unraveling the function of epithelial-mesenchymal transition (EMT) in colorectal cancer: Metastasis, therapy response, and revisiting molecular pathways" @default.
- W4320879159 cites W106969692 @default.
- W4320879159 cites W1757407923 @default.
- W4320879159 cites W1934624334 @default.
- W4320879159 cites W1964847767 @default.
- W4320879159 cites W1966059799 @default.
- W4320879159 cites W1966701340 @default.
- W4320879159 cites W1985400766 @default.
- W4320879159 cites W1991354119 @default.
- W4320879159 cites W1995745530 @default.
- W4320879159 cites W1997585826 @default.
- W4320879159 cites W1999906527 @default.
- W4320879159 cites W2009824580 @default.
- W4320879159 cites W2016360721 @default.
- W4320879159 cites W2028593825 @default.
- W4320879159 cites W2067057174 @default.
- W4320879159 cites W2074486250 @default.
- W4320879159 cites W2085048499 @default.
- W4320879159 cites W2108646620 @default.
- W4320879159 cites W2117925658 @default.
- W4320879159 cites W2142807621 @default.
- W4320879159 cites W2179677472 @default.
- W4320879159 cites W2192136560 @default.
- W4320879159 cites W2239348504 @default.
- W4320879159 cites W2255388447 @default.
- W4320879159 cites W2300010382 @default.
- W4320879159 cites W2302003756 @default.
- W4320879159 cites W2339999512 @default.
- W4320879159 cites W2514148535 @default.
- W4320879159 cites W2518122545 @default.
- W4320879159 cites W2534233135 @default.
- W4320879159 cites W2535002517 @default.
- W4320879159 cites W2575536234 @default.
- W4320879159 cites W2585026947 @default.
- W4320879159 cites W2587809552 @default.
- W4320879159 cites W2591609625 @default.
- W4320879159 cites W2603969536 @default.
- W4320879159 cites W2605577271 @default.
- W4320879159 cites W2607657712 @default.
- W4320879159 cites W2615920181 @default.
- W4320879159 cites W2622305452 @default.
- W4320879159 cites W2624685411 @default.
- W4320879159 cites W2732597986 @default.
- W4320879159 cites W2756355820 @default.
- W4320879159 cites W2773135266 @default.
- W4320879159 cites W2787553551 @default.
- W4320879159 cites W2788766073 @default.
- W4320879159 cites W2790240293 @default.
- W4320879159 cites W2790781519 @default.
- W4320879159 cites W2791383805 @default.
- W4320879159 cites W2792873358 @default.
- W4320879159 cites W2793238663 @default.
- W4320879159 cites W2796444312 @default.
- W4320879159 cites W2799720756 @default.
- W4320879159 cites W2802112266 @default.
- W4320879159 cites W2803063517 @default.
- W4320879159 cites W2805190814 @default.
- W4320879159 cites W2806628670 @default.
- W4320879159 cites W2885622469 @default.
- W4320879159 cites W2887159162 @default.
- W4320879159 cites W2888378416 @default.
- W4320879159 cites W2889622422 @default.
- W4320879159 cites W2889646458 @default.
- W4320879159 cites W2893353454 @default.
- W4320879159 cites W2894552299 @default.
- W4320879159 cites W2896273423 @default.
- W4320879159 cites W2899828884 @default.
- W4320879159 cites W2901068588 @default.
- W4320879159 cites W2902203691 @default.
- W4320879159 cites W2903942029 @default.
- W4320879159 cites W2905132833 @default.
- W4320879159 cites W2911560519 @default.
- W4320879159 cites W2914788175 @default.
- W4320879159 cites W2918104070 @default.
- W4320879159 cites W2922474687 @default.
- W4320879159 cites W2924150174 @default.