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• W4320879658 endingPage "105568" @default.
• W4320879658 startingPage "105568" @default.
• W4320879658 abstract "Polychlorinated biphenyls (PCBs) accumulate in adipose tissue and are linked to obesity and diabetes. The congener, PCB52 (2,2',5,5'-tetrachorobiphenyl), is found at high levels in school air. Hydroxylation of PCB52 to 4-OH-PCB52 (4-hydroxy-2,2',5,5'-tetrachorobiphenyl) may increase its toxicity. To understand PCB52's role in causing adipose dysfunction, we exposed human preadipocytes to PCB52 or 4-OH-PCB52 across a time course and assessed transcript changes using RNAseq. 4-OH-PCB52 caused considerably more changes in the number of differentially expressed genes as compared to PCB52. Both PCB52 and 4-OH-PCB52 upregulated transcript levels of the sulfotransferase SULT1E1 at early time points, but cytochrome P450 genes were generally not affected. A set of genes known to be transcriptionally regulated by PPARα were consistently downregulated by PCB52 at all time points. In contrast, 4-OH-PCB52 affected a variety of pathways, including those involving cytokine responses, hormone responses, focal adhesion, Hippo, and Wnt signaling. Sets of genes known to be transcriptionally regulated by IL17A or parathyroid hormone (PTH) were found to be consistently downregulated by 4-OH-PCB52. Most of the genes affected by PCB52 and 4-OH-PCB52 were different and, of those that were the same, many were changed in an opposite direction. These studies provide insight into how PCB52 or its metabolites may cause adipose dysfunction to cause disease." @default.
• W4320879658 created "2023-02-16" @default.
• W4320879658 creator A5051254377 @default.
• W4320879658 creator A5052737968 @default.
• W4320879658 creator A5052853872 @default.
• W4320879658 creator A5062054709 @default.
• W4320879658 creator A5064106887 @default.
• W4320879658 date "2023-06-01" @default.
• W4320879658 modified "2023-10-02" @default.
• W4320879658 title "Hydroxylation markedly alters how the polychlorinated biphenyl (PCB) congener, PCB52, affects gene expression in human preadipocytes" @default.
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• W4320879658 cites W203452437 @default.
• W4320879658 cites W2064016285 @default.
• W4320879658 cites W2066092624 @default.
• W4320879658 cites W2066417769 @default.
• W4320879658 cites W2081539526 @default.
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• W4320879658 cites W2085900115 @default.
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• W4320879658 cites W2122275827 @default.
• W4320879658 cites W2135230352 @default.
• W4320879658 cites W2137309569 @default.
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• W4320879658 cites W2592811885 @default.
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• W4320879658 doi "https://doi.org/10.1016/j.tiv.2023.105568" @default.
• W4320879658 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36804509" @default.
• W4320879658 hasPublicationYear "2023" @default.
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