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• W4320889724 abstract "The response to cardiac resynchronization therapy (CRT) is suboptimal in one-third of patients.The study aimed to evaluate the impact of sleep-disordered breathing (SDB) on the CRT-induced left ventricular (LV) reverse remodeling and response for CRT in patients with ischemic congestive heart failure (CHF).A total of 37 patients aged 65.43 years (SD 6.05), seven of whom were females, were treated with CRT according to class I European Society of Cardiology recommendations. Clinical evaluation, polysomnography, and contrast echocardiography were performed twice during the six-month follow-up (6M-FU) to assess the effect of CRT.In 33 patients (89.1%), sleep-disordered breathing (SDB), predominantly central sleep apnea (70.3%) was observed. This include nine patients (24.3%) with an apnea-hypopnea index (AHI) of >30 events/hour. During the 6M-FU, 16 patients (47.1%) responded to CRT by reducing LV end-systolic volume index (LVESVi) by ≥15%. We stated a directly proportional linear relationship between AHI value and LV volume: LVESVi p = 0.004, and LV end-diastolic volume index p = 0.006.Pre-existing severe SDB can impair the LV volumetric response to CRT even in an optimally selected group with class I indications for resynchronization, which may have an impact on long-term prognosis." @default.
• W4320889724 created "2023-02-16" @default.
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• W4320889724 date "2023-05-01" @default.
• W4320889724 modified "2023-09-27" @default.
• W4320889724 title "Severe sleep apnea as a predictor of failure to respond to cardiac resynchronization therapy" @default.
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• W4320889724 doi "https://doi.org/10.1016/j.hrtlng.2023.01.018" @default.
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