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- W4320898905 abstract "Abstract Multi-locus transcranial magnetic stimulation (mTMS) is an emerging technology that uses multiple overlapping stimulation coils to spatially manipulate the profile of the induced electric field on the cortex, based on the superposition principle. Instead of physically moving the transducer, the location of stimulation can be electronically adjusted on millimeter and millisecond scales. Previously, we have demonstrated this technology in a research environment. Next, we will provide one mTMS device for safe use in a clinical setting. Our new device contains five independent channels and is therefore able to drive five stimulation coils simultaneously. The system is based on a field-programmable gate array (FPGA) core, similar to our previous devices. To accomplish the clinical transition, we have introduced multiple layers of safety to both software and hardware side. The hardware is designed to be inherently at least single-fault safe, that is, two or more independent failures must occur before there is a malfunction that poses any risk. Our system also transmits and monitors periodic heartbeat messages between its subsystems, indicating proper operation. The microcontrollers inside the mTMS cabinet monitor various internal fault conditions, as well as external events, such as corrupted data packets and missing heartbeats. If a safety-critical fault occurs, the microcontrollers disable the mTMS device. Defensive programming practices were used in the design of the system software. However, as it is difficult to produce completely error-free code, the internal microcontrollers are used in parallel with dedicated emergency hardware. We also built an accompanying five-coil transducer, which follows medical device regulations with two means of patient protection and a robust exterior. In addition, the transducer contains integrated memory for storing coil-related data, such as a unique identifier for each coil to prevent the use of unauthorized coils. Our latest stimulation device enables safer-than-before mTMS in a clinical setting. Research Category and Technology and Methods Translational Research: 10. Transcranial Magnetic Stimulation (TMS) Keywords: mTMS, clinical, safety, hardware" @default.
- W4320898905 created "2023-02-16" @default.
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- W4320898905 date "2023-01-01" @default.
- W4320898905 modified "2023-10-18" @default.
- W4320898905 title "Deploying a multi-locus TMS device in a clinical environment" @default.
- W4320898905 doi "https://doi.org/10.1016/j.brs.2023.01.610" @default.
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