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- W4320898924 abstract "Abstract Treatment-resistant depression accounts for 30% of cases of major depressive disorder, representing a substantial humanistic and economic burden. Electroconvulsive therapy (ECT), an electrical stimulation of the brain which triggers a generalized seizure, provides a chance of relief for such cases. Although beneficial, the precise antidepressant mechanisms of ECT remain to be determined. We expect that ECT induces changes in brain network communication. Eight depressed patients underwent three ECT sessions per week for a total of 16 sessions on average. Functional magnetic resonance imaging (fMRI) was performed before starting the therapy and once a week for four weeks to investigate functional graph theoretical measures of brain connectivity. The complex structure and function of the brain can be described as a graph which is defined as a set of nodes (brain regions) linked by edges (connections). Here we show that several regions included in default mode (DMN), cognitive control (CC) and somatomotor (SM) networks change the number of connections (degree) during four weeks of therapy. In particular, the degree of SM regions (PreCG) and CC regions (IFG, MFG) decreases from week one to week two and increases again in week three. Interestingly, these changes mostly occur between the first and the third week, suggesting that the main effect of ECT on brain connectivity takes place at the very early stages of the therapy, although the first effects on the clinical outcome emerge only later around week four. Those regions have been associated with regulation of emotion expression, language and semantic memory processing, all functions known to be affected in depression. Altogether our results are compatible with a reorganization of brain connections as a consequence of ECT. This work has been supported by the German Research Council (DFG- GRK2174). PreCG = Precentral Gyrus; IFG = Inferior Frontal Gyrus; MFG = Medial Frontal Gyrus Research Category and Technology and Methods Clinical Research: 2. Electroconvulsive Therapy (ECT) Keywords: ECT, Functional Connectivity, Graph Theory, Depression" @default.
- W4320898924 created "2023-02-16" @default.
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- W4320898924 date "2023-01-01" @default.
- W4320898924 modified "2023-09-23" @default.
- W4320898924 title "Electroconvulsive therapy changes functional brain connectivity in depressed patients" @default.
- W4320898924 doi "https://doi.org/10.1016/j.brs.2023.01.594" @default.
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