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• W4320912639 endingPage "106201" @default.
• W4320912639 startingPage "106201" @default.
• W4320912639 abstract "A cell's genome influences its metabolism via the expression of enzyme-related genes, but transcriptome and fluxome are not perfectly correlated as post-transcriptional mechanisms also regulate reaction's kinetics. Here, we addressed the question: given a transcriptome, how unobserved mechanisms of reaction kinetics should be systematically accounted for when inferring the fluxome? To infer the most likely and least biased fluxome, we present Pheflux, a constraint-based model maximizing Shannon's entropy of fluxes per mRNA. Benchmarked against 13C fluxes of yeast and bacteria, Pheflux accurately estimates the carbon core metabolism. We applied Pheflux to thousands of normal and tumor cell transcriptomes obtained from The Cancer Genome Atlas. Pheflux showed statistically significantly higher glucose yields on lactate in breast, kidney, and bronchus-lung tumoral cells than their normal counterparts. Results are consistent with the Warburg effect, a hallmark of cancer metabolism, suggesting that Pheflux can be efficiently used to study the metabolism of eukaryotic cells." @default.
• W4320912639 created "2023-02-16" @default.
• W4320912639 creator A5007333292 @default.
• W4320912639 creator A5017061653 @default.
• W4320912639 creator A5029085109 @default.
• W4320912639 creator A5079383703 @default.
• W4320912639 date "2023-03-01" @default.
• W4320912639 modified "2023-09-26" @default.
• W4320912639 title "Phenotype-specific estimation of metabolic fluxes using gene expression data" @default.
• W4320912639 cites W1577822803 @default.
• W4320912639 cites W1597762351 @default.
• W4320912639 cites W1754578874 @default.
• W4320912639 cites W1862094217 @default.
• W4320912639 cites W1960974681 @default.
• W4320912639 cites W1965555277 @default.
• W4320912639 cites W1973268693 @default.
• W4320912639 cites W1995875735 @default.
• W4320912639 cites W1998166655 @default.
• W4320912639 cites W2006333907 @default.
• W4320912639 cites W2011514820 @default.
• W4320912639 cites W2012991302 @default.
• W4320912639 cites W2018669333 @default.
• W4320912639 cites W2021274204 @default.
• W4320912639 cites W2025663053 @default.
• W4320912639 cites W2026089579 @default.
• W4320912639 cites W2027358346 @default.
• W4320912639 cites W2030776070 @default.
• W4320912639 cites W2032558547 @default.
• W4320912639 cites W2034354682 @default.
• W4320912639 cites W2044306109 @default.
• W4320912639 cites W2045921664 @default.
• W4320912639 cites W2048020475 @default.
• W4320912639 cites W2048465561 @default.
• W4320912639 cites W2068262501 @default.
• W4320912639 cites W2072451938 @default.
• W4320912639 cites W2077460182 @default.
• W4320912639 cites W2077545398 @default.
• W4320912639 cites W2078355959 @default.
• W4320912639 cites W2079531107 @default.
• W4320912639 cites W2085236271 @default.
• W4320912639 cites W2101967659 @default.
• W4320912639 cites W2102921564 @default.
• W4320912639 cites W2105525072 @default.
• W4320912639 cites W2107409961 @default.
• W4320912639 cites W2109240447 @default.
• W4320912639 cites W2113440476 @default.
• W4320912639 cites W2117474489 @default.
• W4320912639 cites W2117692326 @default.
• W4320912639 cites W2118258530 @default.
• W4320912639 cites W2123542593 @default.
• W4320912639 cites W2123871098 @default.
• W4320912639 cites W2124653577 @default.
• W4320912639 cites W2124737787 @default.
• W4320912639 cites W2141360045 @default.
• W4320912639 cites W2141635203 @default.
• W4320912639 cites W2142270568 @default.
• W4320912639 cites W2144589197 @default.
• W4320912639 cites W2147229554 @default.
• W4320912639 cites W2154061034 @default.
• W4320912639 cites W2154146618 @default.
• W4320912639 cites W2161782059 @default.
• W4320912639 cites W2162666840 @default.
• W4320912639 cites W2162673839 @default.
• W4320912639 cites W2162790428 @default.
• W4320912639 cites W2169456326 @default.
• W4320912639 cites W2172129062 @default.
• W4320912639 cites W2234115940 @default.
• W4320912639 cites W2238595451 @default.
• W4320912639 cites W2258066491 @default.
• W4320912639 cites W2293953879 @default.
• W4320912639 cites W2333535089 @default.
• W4320912639 cites W2395626624 @default.
• W4320912639 cites W2470538762 @default.
• W4320912639 cites W2587946751 @default.
• W4320912639 cites W2594846523 @default.
• W4320912639 cites W2610736935 @default.
• W4320912639 cites W2612533264 @default.
• W4320912639 cites W2680456958 @default.
• W4320912639 cites W2736303938 @default.
• W4320912639 cites W2769160949 @default.
• W4320912639 cites W2789128799 @default.
• W4320912639 cites W2817023813 @default.
• W4320912639 cites W2842089854 @default.
• W4320912639 cites W2885822827 @default.
• W4320912639 cites W2888708599 @default.
• W4320912639 cites W2890508160 @default.
• W4320912639 cites W2898321887 @default.
• W4320912639 cites W2899760200 @default.
• W4320912639 cites W2919939168 @default.
• W4320912639 cites W2924849767 @default.
• W4320912639 cites W2947953792 @default.
• W4320912639 cites W2948594834 @default.
• W4320912639 cites W2949144734 @default.
• W4320912639 cites W2965102054 @default.
• W4320912639 cites W2969304020 @default.
• W4320912639 cites W2982521190 @default.
• W4320912639 cites W3009746164 @default.
• W4320912639 cites W3026940454 @default.

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