FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4320912708> ?p ?o ?g. }

• W4320912708 endingPage "122052" @default.
• W4320912708 startingPage "122052" @default.
• W4320912708 abstract "Physiological barriers and immunosuppressive microenvironments of solid tumors present considerable hurdles to Chimeric antigen receptor T (CAR-T) cell therapy. Herein, we discovered that metformin, a prescribed drug for type 2 diabetes, could up-regulate the oxidative phosphorylation of CAR-T cells, increase their energy metabolism, and further promote their proliferation. Inspired by this finding, we designed a hydrogel scaffold to co-deliver metformin and CAR-T cells by adding CAR-T cells into a lyophilized alginate hydrogel containing metformin. The obtained hydrogel scaffold after being implanted into the tumor resection cavity could act as a cell reservoir to sustainably release both CAR-T cells and metformin. While the released metformin could suppress oxidative and glycolytic metabolism of cancer cells and lead to decreased tumor hypoxia, CAR-T cells would respond to metformin by markedly up-regulating oxidative metabolism and adopting a long-lived, highly activated phenotype, contributing to elevated antitumor responses. As demonstrated in several post-surgical tumor models, the proliferation and tumor-infiltration of CAR-T cells were significantly enhanced and the treatment efficacy of CAR-T cells was augmented, against both local tumors and distant abscopal tumors, while showing reduced systemic immune-related adverse effects. Our work presents a new strategy to achieve effective yet safe CAR-T therapy against solid tumors using a cell-delivery scaffold based on clinically validated drugs and biomaterials." @default.
• W4320912708 created "2023-02-16" @default.
• W4320912708 creator A5009612843 @default.
• W4320912708 creator A5013233914 @default.
• W4320912708 creator A5013673244 @default.
• W4320912708 creator A5039010191 @default.
• W4320912708 creator A5042371557 @default.
• W4320912708 creator A5057767596 @default.
• W4320912708 creator A5068290128 @default.
• W4320912708 creator A5069526251 @default.
• W4320912708 creator A5084452813 @default.
• W4320912708 creator A5090815103 @default.
• W4320912708 date "2023-04-01" @default.
• W4320912708 modified "2023-10-13" @default.
• W4320912708 title "Metformin-containing hydrogel scaffold to augment CAR-T therapy against post-surgical solid tumors" @default.
• W4320912708 cites W1976993918 @default.
• W4320912708 cites W1981883819 @default.
• W4320912708 cites W1982795546 @default.
• W4320912708 cites W1990602451 @default.
• W4320912708 cites W1994993231 @default.
• W4320912708 cites W2010238890 @default.
• W4320912708 cites W2044835625 @default.
• W4320912708 cites W2060070314 @default.
• W4320912708 cites W2066671159 @default.
• W4320912708 cites W2078190084 @default.
• W4320912708 cites W2101018683 @default.
• W4320912708 cites W2134907909 @default.
• W4320912708 cites W2154024784 @default.
• W4320912708 cites W2158822657 @default.
• W4320912708 cites W2160571820 @default.
• W4320912708 cites W2165503577 @default.
• W4320912708 cites W2408097265 @default.
• W4320912708 cites W2773804840 @default.
• W4320912708 cites W2779417696 @default.
• W4320912708 cites W2783878221 @default.
• W4320912708 cites W2792588868 @default.
• W4320912708 cites W2800948756 @default.
• W4320912708 cites W2807110328 @default.
• W4320912708 cites W2911543360 @default.
• W4320912708 cites W2967618321 @default.
• W4320912708 cites W2969758768 @default.
• W4320912708 cites W2985764787 @default.
• W4320912708 cites W2986629061 @default.
• W4320912708 cites W2991931596 @default.
• W4320912708 cites W2995900562 @default.
• W4320912708 cites W3013752652 @default.
• W4320912708 cites W3157425701 @default.
• W4320912708 doi "https://doi.org/10.1016/j.biomaterials.2023.122052" @default.
• W4320912708 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36827893" @default.
• W4320912708 hasPublicationYear "2023" @default.
• W4320912708 type Work @default.
• W4320912708 citedByCount "2" @default.
• W4320912708 countsByYear W43209127082023 @default.
• W4320912708 crossrefType "journal-article" @default.
• W4320912708 hasAuthorship W4320912708A5009612843 @default.
• W4320912708 hasAuthorship W4320912708A5013233914 @default.
• W4320912708 hasAuthorship W4320912708A5013673244 @default.
• W4320912708 hasAuthorship W4320912708A5039010191 @default.
• W4320912708 hasAuthorship W4320912708A5042371557 @default.
• W4320912708 hasAuthorship W4320912708A5057767596 @default.
• W4320912708 hasAuthorship W4320912708A5068290128 @default.
• W4320912708 hasAuthorship W4320912708A5069526251 @default.
• W4320912708 hasAuthorship W4320912708A5084452813 @default.
• W4320912708 hasAuthorship W4320912708A5090815103 @default.
• W4320912708 hasConcept C126322002 @default.
• W4320912708 hasConcept C136229726 @default.
• W4320912708 hasConcept C203014093 @default.
• W4320912708 hasConcept C2777701055 @default.
• W4320912708 hasConcept C2779306644 @default.
• W4320912708 hasConcept C2780323712 @default.
• W4320912708 hasConcept C3875195 @default.
• W4320912708 hasConcept C502942594 @default.
• W4320912708 hasConcept C71924100 @default.
• W4320912708 hasConcept C8891405 @default.
• W4320912708 hasConcept C89429830 @default.
• W4320912708 hasConcept C98274493 @default.
• W4320912708 hasConceptScore W4320912708C126322002 @default.
• W4320912708 hasConceptScore W4320912708C136229726 @default.
• W4320912708 hasConceptScore W4320912708C203014093 @default.
• W4320912708 hasConceptScore W4320912708C2777701055 @default.
• W4320912708 hasConceptScore W4320912708C2779306644 @default.
• W4320912708 hasConceptScore W4320912708C2780323712 @default.
• W4320912708 hasConceptScore W4320912708C3875195 @default.
• W4320912708 hasConceptScore W4320912708C502942594 @default.
• W4320912708 hasConceptScore W4320912708C71924100 @default.
• W4320912708 hasConceptScore W4320912708C8891405 @default.
• W4320912708 hasConceptScore W4320912708C89429830 @default.
• W4320912708 hasConceptScore W4320912708C98274493 @default.
• W4320912708 hasFunder F4320321001 @default.
• W4320912708 hasFunder F4320321540 @default.
• W4320912708 hasLocation W43209127081 @default.
• W4320912708 hasLocation W43209127082 @default.
• W4320912708 hasOpenAccess W4320912708 @default.
• W4320912708 hasPrimaryLocation W43209127081 @default.
• W4320912708 hasRelatedWork W2105403615 @default.
• W4320912708 hasRelatedWork W2350706782 @default.
• W4320912708 hasRelatedWork W2520648843 @default.
• W4320912708 hasRelatedWork W2904715359 @default.

• next