FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4320920912> ?p ?o ?g. }

• W4320920912 abstract "Maltol, a chemical isolated from ginseng root, has shown treatment effects on several pathological processes including osteoarthritis, diabetic peripheral neuropathy and liver fibrosis. Nevertheless, its effect on ischemia‑induced neuron death remains elusive. In the present study, the treatment effect of maltol on ischemia‑induced neuron damage was investigated by using oxygen and glucose deprivation (OGD) model in SH‑SY5Y cells. In vitro studies revealed that maltol protected SH‑SY5Y cells against OGD‑induced chromatinolysis by inhibiting two reactive oxygen species (ROS)‑regulated pathways. One was DNA double‑strand breaks and the other was nuclear translocation of apoptosis inducing factor. Mechanistically, maltol not only inhibited OGD‑induced depletion of glutathione and cysteine by maintaining cystine/glutamate antiporter (xCT) level, but also abrogated OGD‑induced catalase downregulation. Meanwhile, maltol also alleviated OGD‑induced inactivation of mTOR by attenuating OGD‑induced depletion of adenosine triphosphate and pyruvate and downregulation of pyruvate kinase M2, indicating that maltol inhibited the glycolysis dysfunction caused by OGD. Considering that activated mammalian target of the rapamycin (mTOR) could lead to enhanced xCT expression and decreased catalase degradation by autophagy, these findings indicated that maltol attenuated OGD‑induced ROS via inhibition of mTOR inactivation by maintaining pyruvate level. Taken together, it was demonstrated that maltol prevented OGD‑induced chromatinolysis in SH‑SY5Y cells via inhibiting pyruvate depletion." @default.
• W4320920912 created "2023-02-16" @default.
• W4320920912 creator A5001354020 @default.
• W4320920912 creator A5001877853 @default.
• W4320920912 creator A5012627399 @default.
• W4320920912 creator A5024105936 @default.
• W4320920912 creator A5031393768 @default.
• W4320920912 creator A5032447166 @default.
• W4320920912 creator A5085960035 @default.
• W4320920912 date "2023-02-15" @default.
• W4320920912 modified "2023-10-16" @default.
• W4320920912 title "Maltol inhibits oxygen glucose deprivation‑induced chromatinolysis in SH‑SY5Y cells by maintaining pyruvate level" @default.
• W4320920912 cites W110937187 @default.
• W4320920912 cites W1893330971 @default.
• W4320920912 cites W1968355999 @default.
• W4320920912 cites W1974704809 @default.
• W4320920912 cites W1991905088 @default.
• W4320920912 cites W1994056283 @default.
• W4320920912 cites W2012473171 @default.
• W4320920912 cites W2013969500 @default.
• W4320920912 cites W2014632136 @default.
• W4320920912 cites W2023105087 @default.
• W4320920912 cites W2033659755 @default.
• W4320920912 cites W2041132940 @default.
• W4320920912 cites W2061352374 @default.
• W4320920912 cites W2068057586 @default.
• W4320920912 cites W2070999322 @default.
• W4320920912 cites W2074573663 @default.
• W4320920912 cites W2081721333 @default.
• W4320920912 cites W2085641738 @default.
• W4320920912 cites W2088923308 @default.
• W4320920912 cites W2098803781 @default.
• W4320920912 cites W2107052529 @default.
• W4320920912 cites W2152745581 @default.
• W4320920912 cites W2157817912 @default.
• W4320920912 cites W2159700384 @default.
• W4320920912 cites W2207241376 @default.
• W4320920912 cites W2438266306 @default.
• W4320920912 cites W2494508624 @default.
• W4320920912 cites W2529744299 @default.
• W4320920912 cites W2572671324 @default.
• W4320920912 cites W2589512071 @default.
• W4320920912 cites W2765159648 @default.
• W4320920912 cites W2792259092 @default.
• W4320920912 cites W2806752661 @default.
• W4320920912 cites W2888531326 @default.
• W4320920912 cites W2897537410 @default.
• W4320920912 cites W2899013235 @default.
• W4320920912 cites W2907769305 @default.
• W4320920912 cites W2909653888 @default.
• W4320920912 cites W2913399313 @default.
• W4320920912 cites W2936393252 @default.
• W4320920912 cites W2972439814 @default.
• W4320920912 cites W2976791673 @default.
• W4320920912 cites W3002002742 @default.
• W4320920912 cites W3007652947 @default.
• W4320920912 cites W3017396649 @default.
• W4320920912 cites W3048002582 @default.
• W4320920912 cites W3049497414 @default.
• W4320920912 cites W3092022851 @default.
• W4320920912 cites W3094418162 @default.
• W4320920912 cites W3116434720 @default.
• W4320920912 cites W3153828319 @default.
• W4320920912 cites W3154805784 @default.
• W4320920912 cites W3156308715 @default.
• W4320920912 cites W3165367403 @default.
• W4320920912 cites W3165650254 @default.
• W4320920912 cites W3193296945 @default.
• W4320920912 cites W3213051522 @default.
• W4320920912 cites W4210364322 @default.
• W4320920912 cites W4210551130 @default.
• W4320920912 cites W4250120894 @default.
• W4320920912 cites W4283749475 @default.
• W4320920912 doi "https://doi.org/10.3892/mmr.2023.12962" @default.
• W4320920912 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36799163" @default.
• W4320920912 hasPublicationYear "2023" @default.
• W4320920912 type Work @default.
• W4320920912 citedByCount "0" @default.
• W4320920912 crossrefType "journal-article" @default.
• W4320920912 hasAuthorship W4320920912A5001354020 @default.
• W4320920912 hasAuthorship W4320920912A5001877853 @default.
• W4320920912 hasAuthorship W4320920912A5012627399 @default.
• W4320920912 hasAuthorship W4320920912A5024105936 @default.
• W4320920912 hasAuthorship W4320920912A5031393768 @default.
• W4320920912 hasAuthorship W4320920912A5032447166 @default.
• W4320920912 hasAuthorship W4320920912A5085960035 @default.
• W4320920912 hasBestOaLocation W43209209121 @default.
• W4320920912 hasConcept C104317684 @default.
• W4320920912 hasConcept C127561419 @default.
• W4320920912 hasConcept C134018914 @default.
• W4320920912 hasConcept C185592680 @default.
• W4320920912 hasConcept C190283241 @default.
• W4320920912 hasConcept C20251656 @default.
• W4320920912 hasConcept C2776715637 @default.
• W4320920912 hasConcept C2777633133 @default.
• W4320920912 hasConcept C2777866211 @default.
• W4320920912 hasConcept C2777952866 @default.
• W4320920912 hasConcept C2778616655 @default.
• W4320920912 hasConcept C2779083432 @default.
• W4320920912 hasConcept C2779306644 @default.

• next