FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4320921173> ?p ?o ?g. }

• W4320921173 endingPage "101746" @default.
• W4320921173 startingPage "101746" @default.
• W4320921173 abstract "Post-transplant human cytomegalovirus (HCMV) viremia has been linked to adverse “indirect effects” among transplant patients. HCMV-created immunomodulatory mechanisms could be associated with the indirect effects. In the present study, the RNA-Seq whole transcriptome of renal transplant (RT) patients was analyzed to seek the underlying pathobiologic pathways associated with the long-term indirect effects of HCMV. To investigate the activated biological pathways in HCMV infection, total RNA was extracted from PBMCs of 2 RT patients with active HCMV and 2 RT patients without infection and then were sequenced using RNA-Seq. The resulted raw data were analyzed by conventional RNA-Seq software to determine the Differentially Expressed Genes (DEGs). Afterward, Gene Ontology (GO) and pathway enrichment analyses were conducted to determine the enriched pathways and biological processes by DEGs. Eventually, the relative expressions of some significant genes were validated in the twenty external RT patients. The analysis of RNA-Seq data related to RT patients with HCMV active viremia led to the identification of 140 up-regulated and 100 down-regulated DEGs. KEGG pathway analysis revealed the enrichment of DEGs in IL18 signaling, AGE-RAGE signaling pathway in diabetic complications, signaling by GPCR, Platelet activation, signaling and aggregation, Estrogen signaling pathway and signaling by Wnt due to HCMV infection. The expression levels of six genes involved in enriched pathways including F3, PTX3, ADRA2B, GNG11, GP9, HBEGF were then verified using RT-qPCR. The results were in consistent with RNA-Seq resultsoutcomes. This study specifies some pathobiological pathways which are activated in HCMV active infection and could be linked to the adverse indirect effects caused by HCMV infection in transplant patients." @default.
• W4320921173 created "2023-02-16" @default.
• W4320921173 creator A5037827662 @default.
• W4320921173 creator A5039254259 @default.
• W4320921173 creator A5049023657 @default.
• W4320921173 creator A5063570297 @default.
• W4320921173 creator A5065225733 @default.
• W4320921173 creator A5069135689 @default.
• W4320921173 date "2023-06-01" @default.
• W4320921173 modified "2023-09-27" @default.
• W4320921173 title "Transcriptomic analysis of human cytomegalovirus to survey the indirect effects on renal transplant recipients" @default.
• W4320921173 cites W1526773517 @default.
• W4320921173 cites W1543281579 @default.
• W4320921173 cites W1891745438 @default.
• W4320921173 cites W1940100272 @default.
• W4320921173 cites W1957027480 @default.
• W4320921173 cites W1964804755 @default.
• W4320921173 cites W1970074064 @default.
• W4320921173 cites W1977047885 @default.
• W4320921173 cites W1991966640 @default.
• W4320921173 cites W1993607801 @default.
• W4320921173 cites W1995344215 @default.
• W4320921173 cites W1997573685 @default.
• W4320921173 cites W2030825396 @default.
• W4320921173 cites W2035597292 @default.
• W4320921173 cites W2039924078 @default.
• W4320921173 cites W2044437167 @default.
• W4320921173 cites W2045022969 @default.
• W4320921173 cites W2045688706 @default.
• W4320921173 cites W2048425686 @default.
• W4320921173 cites W2049855978 @default.
• W4320921173 cites W2059937450 @default.
• W4320921173 cites W2062077711 @default.
• W4320921173 cites W2067394439 @default.
• W4320921173 cites W2068604359 @default.
• W4320921173 cites W2069432896 @default.
• W4320921173 cites W2069578209 @default.
• W4320921173 cites W2074142559 @default.
• W4320921173 cites W2075642185 @default.
• W4320921173 cites W2080535870 @default.
• W4320921173 cites W2086327676 @default.
• W4320921173 cites W2087762810 @default.
• W4320921173 cites W2087959682 @default.
• W4320921173 cites W2102895007 @default.
• W4320921173 cites W2107277218 @default.
• W4320921173 cites W2119887046 @default.
• W4320921173 cites W2120886013 @default.
• W4320921173 cites W2122534786 @default.
• W4320921173 cites W2133771865 @default.
• W4320921173 cites W2146994504 @default.
• W4320921173 cites W2153066661 @default.
• W4320921173 cites W2158109120 @default.
• W4320921173 cites W2158927882 @default.
• W4320921173 cites W2160100702 @default.
• W4320921173 cites W2161029289 @default.
• W4320921173 cites W2161305783 @default.
• W4320921173 cites W2322522340 @default.
• W4320921173 cites W2330102954 @default.
• W4320921173 cites W2468328496 @default.
• W4320921173 cites W2531485683 @default.
• W4320921173 cites W2567489795 @default.
• W4320921173 cites W2592685644 @default.
• W4320921173 cites W2791754249 @default.
• W4320921173 cites W2794256929 @default.
• W4320921173 cites W2891704573 @default.
• W4320921173 cites W2924184478 @default.
• W4320921173 cites W2974266187 @default.
• W4320921173 cites W3006103463 @default.
• W4320921173 cites W3021841162 @default.
• W4320921173 cites W3043029189 @default.
• W4320921173 cites W3087674367 @default.
• W4320921173 cites W3106271757 @default.
• W4320921173 cites W3213623440 @default.
• W4320921173 cites W4255668464 @default.
• W4320921173 cites W861551241 @default.
• W4320921173 doi "https://doi.org/10.1016/j.trim.2022.101746" @default.
• W4320921173 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36796459" @default.
• W4320921173 hasPublicationYear "2023" @default.
• W4320921173 type Work @default.
• W4320921173 citedByCount "0" @default.
• W4320921173 crossrefType "journal-article" @default.
• W4320921173 hasAuthorship W4320921173A5037827662 @default.
• W4320921173 hasAuthorship W4320921173A5039254259 @default.
• W4320921173 hasAuthorship W4320921173A5049023657 @default.
• W4320921173 hasAuthorship W4320921173A5063570297 @default.
• W4320921173 hasAuthorship W4320921173A5065225733 @default.
• W4320921173 hasAuthorship W4320921173A5069135689 @default.
• W4320921173 hasConcept C104317684 @default.
• W4320921173 hasConcept C137620995 @default.
• W4320921173 hasConcept C150194340 @default.
• W4320921173 hasConcept C152724338 @default.
• W4320921173 hasConcept C162317418 @default.
• W4320921173 hasConcept C203014093 @default.
• W4320921173 hasConcept C2522874641 @default.
• W4320921173 hasConcept C2776185481 @default.
• W4320921173 hasConcept C2779820661 @default.
• W4320921173 hasConcept C54355233 @default.
• W4320921173 hasConcept C62478195 @default.

• next