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- W4320921397 endingPage "188863" @default.
- W4320921397 startingPage "188863" @default.
- W4320921397 abstract "This review is an overview of the current knowledge regarding circulating tumour cells (CTCs), which are potentially the most lethal type of cancer cell, and may be a key component of the metastatic cascade. The clinical utility of CTCs (the Good), includes their diagnostic, prognostic, and therapeutic potential. Conversely, their complex biology (the Bad), including the existence of CD45+/EpCAM+ CTCs, adds insult to injury regarding their isolation and identification, which in turn hampers their clinical translation. CTCs are capable of forming microemboli composed of both non-discrete phenotypic populations such as mesenchymal CTCs and homotypic and heterotypic clusters which are poised to interact with other cells in the circulation, including immune cells and platelets, which may increase their malignant potential. These microemboli (the Ugly) represent a prognostically important CTC subset, however, phenotypic EMT/MET gradients bring additional complexities to an already challenging situation." @default.
- W4320921397 created "2023-02-16" @default.
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- W4320921397 creator A5081743412 @default.
- W4320921397 date "2023-03-01" @default.
- W4320921397 modified "2023-10-16" @default.
- W4320921397 title "Circulating tumour cells: The Good, the Bad and the Ugly" @default.
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