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- W4320921569 endingPage "106035" @default.
- W4320921569 startingPage "106035" @default.
- W4320921569 abstract "The clearance function is essential for maintaining brain tissue homeostasis, and the glymphatic system is the main pathway for removing brain interstitial solutes. Aquaporin-4 (AQP4) is the most abundantly expressed aquaporin in the central nervous system (CNS) and is an integral component of the glymphatic system. In recent years, many studies have shown that AQP4 affects the morbidity and recovery process of CNS disorders through the glymphatic system, and AQP4 shows notable variability in CNS disorders and is part of the pathogenesis of these diseases. Therefore, there has been considerable interest in AQP4 as a potential and promising target for regulating and improving neurological impairment. This review aims to summarize the pathophysiological role that AQP4 plays in several CNS disorders by affecting the clearance function of the glymphatic system. The findings can contribute to a better understanding of the self-regulatory functions in CNS disorders that AQP4 were involved in and provide new therapeutic alternatives for incurable debilitating neurodegenerative disorders of CNS in the future." @default.
- W4320921569 created "2023-02-16" @default.
- W4320921569 creator A5011842437 @default.
- W4320921569 creator A5031520395 @default.
- W4320921569 creator A5052077609 @default.
- W4320921569 creator A5067689496 @default.
- W4320921569 creator A5086932871 @default.
- W4320921569 date "2023-04-01" @default.
- W4320921569 modified "2023-10-03" @default.
- W4320921569 title "Aquaporin-4 in glymphatic system, and its implication for central nervous system disorders" @default.
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