FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4320921618> ?p ?o ?g. }

• W4320921618 endingPage "147" @default.
• W4320921618 startingPage "147" @default.
• W4320921618 abstract "Histidine triad nucleotide binding protein 1 (HINT1) is a haplo-insufficient tumor suppressor gene that plays a significant role in cell proliferation and survival. However, to date, no systematic pan-cancer analysis has been conducted to explore its function in prognosis, and its oncogenic and immunological roles. We also analyzed the role of HINT1 in breast cancer (BC) progression in vitro.An analysis of the HINT1 expression pattern was performed using the TIMER database. The infiltration of immune cells into several cancer types was also studied using the Xena Shiny tool. To determine the relationship between stemness and the expression of HINT1 mRNA, the Spearman correlation test was used with the SangerBox tool. The correlation between HINT1 and functional states in various cancers was determined from the CancerSEA database. The potential role of HINT1 in BC oncogenesis was also investigated by Western blot and Annexin V/PI assays.The Cancer Genome Atlas pan-cancer data analysis suggested that HINT1 was extensively altered in most tumor tissues but not in most adjacent normal tissues. A high expression of HINT1 was associated with the decreased infiltration of cluster of differentiation (CD)4+ T cells. Importantly, increased HINT1 expression was also associated with a large majority of tumors with high stemness and lower stromal, immune, and estimate scores. Further, the expression of HINT1 was significantly associated with the tumor mutational burden (TMB) and microsatellite instability (MSI) in certain tumor types. Finally, HINT1 overexpression was found to impair BC progression by promoting cell apoptosis. HINT1 upregulation also reduced the expression of microphthalmia transcription factor (MITF) and β-catenin in BC Michigan Cancer Foundation-7 (MCF-7) cells, and the phosphorylation of protein kinase B (p-Akt).The present study showed that HINT1 plays an oncogenic role in various cancers and could also be used as a biomarker for BC." @default.
• W4320921618 created "2023-02-16" @default.
• W4320921618 creator A5019277227 @default.
• W4320921618 creator A5026927881 @default.
• W4320921618 creator A5065625643 @default.
• W4320921618 date "2023-02-01" @default.
• W4320921618 modified "2023-09-24" @default.
• W4320921618 title "The oncogenic and immunological roles of histidine triad nucleotide-binding protein 1 in human cancers and their experimental validation in the MCF-7 cell line" @default.
• W4320921618 cites W1978208403 @default.
• W4320921618 cites W2009203565 @default.
• W4320921618 cites W2011968242 @default.
• W4320921618 cites W2048756941 @default.
• W4320921618 cites W2054673335 @default.
• W4320921618 cites W2057206198 @default.
• W4320921618 cites W2057259362 @default.
• W4320921618 cites W2084641677 @default.
• W4320921618 cites W2143772132 @default.
• W4320921618 cites W2143831002 @default.
• W4320921618 cites W2284496227 @default.
• W4320921618 cites W2507880739 @default.
• W4320921618 cites W2519225498 @default.
• W4320921618 cites W2600453489 @default.
• W4320921618 cites W2606495925 @default.
• W4320921618 cites W2607449297 @default.
• W4320921618 cites W2734446741 @default.
• W4320921618 cites W2765224588 @default.
• W4320921618 cites W2770397194 @default.
• W4320921618 cites W2807517751 @default.
• W4320921618 cites W2883204910 @default.
• W4320921618 cites W2893860077 @default.
• W4320921618 cites W2897044695 @default.
• W4320921618 cites W2953947607 @default.
• W4320921618 cites W2969593942 @default.
• W4320921618 cites W2980660242 @default.
• W4320921618 cites W3004434748 @default.
• W4320921618 cites W3024417914 @default.
• W4320921618 cites W3040113149 @default.
• W4320921618 cites W3053552026 @default.
• W4320921618 cites W3081828282 @default.
• W4320921618 cites W3128646645 @default.
• W4320921618 cites W3134553072 @default.
• W4320921618 cites W3138977384 @default.
• W4320921618 cites W3164445611 @default.
• W4320921618 cites W3197001617 @default.
• W4320921618 cites W4309609843 @default.
• W4320921618 doi "https://doi.org/10.21037/atm-22-6637" @default.
• W4320921618 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36846002" @default.
• W4320921618 hasPublicationYear "2023" @default.
• W4320921618 type Work @default.
• W4320921618 citedByCount "1" @default.
• W4320921618 countsByYear W43209216182023 @default.
• W4320921618 crossrefType "journal-article" @default.
• W4320921618 hasAuthorship W4320921618A5019277227 @default.
• W4320921618 hasAuthorship W4320921618A5026927881 @default.
• W4320921618 hasAuthorship W4320921618A5065625643 @default.
• W4320921618 hasBestOaLocation W43209216181 @default.
• W4320921618 hasConcept C104317684 @default.
• W4320921618 hasConcept C121608353 @default.
• W4320921618 hasConcept C16930146 @default.
• W4320921618 hasConcept C180754005 @default.
• W4320921618 hasConcept C203014093 @default.
• W4320921618 hasConcept C2776415932 @default.
• W4320921618 hasConcept C2779767149 @default.
• W4320921618 hasConcept C502942594 @default.
• W4320921618 hasConcept C54355233 @default.
• W4320921618 hasConcept C555283112 @default.
• W4320921618 hasConcept C61320498 @default.
• W4320921618 hasConcept C86803240 @default.
• W4320921618 hasConcept C8891405 @default.
• W4320921618 hasConceptScore W4320921618C104317684 @default.
• W4320921618 hasConceptScore W4320921618C121608353 @default.
• W4320921618 hasConceptScore W4320921618C16930146 @default.
• W4320921618 hasConceptScore W4320921618C180754005 @default.
• W4320921618 hasConceptScore W4320921618C203014093 @default.
• W4320921618 hasConceptScore W4320921618C2776415932 @default.
• W4320921618 hasConceptScore W4320921618C2779767149 @default.
• W4320921618 hasConceptScore W4320921618C502942594 @default.
• W4320921618 hasConceptScore W4320921618C54355233 @default.
• W4320921618 hasConceptScore W4320921618C555283112 @default.
• W4320921618 hasConceptScore W4320921618C61320498 @default.
• W4320921618 hasConceptScore W4320921618C86803240 @default.
• W4320921618 hasConceptScore W4320921618C8891405 @default.
• W4320921618 hasIssue "3" @default.
• W4320921618 hasLocation W43209216181 @default.
• W4320921618 hasLocation W43209216182 @default.
• W4320921618 hasLocation W43209216183 @default.
• W4320921618 hasOpenAccess W4320921618 @default.
• W4320921618 hasPrimaryLocation W43209216181 @default.
• W4320921618 hasRelatedWork W1499339123 @default.
• W4320921618 hasRelatedWork W2008153433 @default.
• W4320921618 hasRelatedWork W2117059884 @default.
• W4320921618 hasRelatedWork W2370772550 @default.
• W4320921618 hasRelatedWork W2803210216 @default.
• W4320921618 hasRelatedWork W2907813288 @default.
• W4320921618 hasRelatedWork W4211076423 @default.
• W4320921618 hasRelatedWork W4225121012 @default.
• W4320921618 hasRelatedWork W4233327219 @default.
• W4320921618 hasRelatedWork W4323808922 @default.

• next